Researchers identify key mutation that promotes melanoma growth by suppressing immune response

University of California, Irvine researchers have identified a specific mutation that allows melanoma tumor cells to remain undetected by the immune system. The finding may lead to the development of better immunotherapies and more effective methods to identify patients that would respond to these new therapies.

The study, "ATR Mutations Promote the Growth of Melanoma Tumors by Modulating the Immune Microenvironment," is published March 7 in the journal Cell Reports.

"Cancers develop not only because they acquire mutations that promote their growth but also because they are able to prevent the immune system from recognizing and removing them," said Anand K. Ganesan, MD, senior author and Associate Professor at the University of California, Irvine. He explained that researchers identified a mutation in the ATR gene, a protein that normally recognizes and repairs UV-induced DNA damage, in melanoma tumors. Cancers with this ATR mutation suppress the body's natural immune response.

"Understanding how developing tumors interact with the immune system to promote their continued growth is a key to developing effective immunotherapies," he said.

Skin cancer is the most common of all cancers, according to the American Cancer Society. In 2017, it’s expected that more than 87,000 new melanomas will be diagnosed (about 52,170 in men and 34,940 in women) and that about 9,730 people are expected to die of the disease.



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