Sartorius Stedim Biotech launches mini bioreactor vessel for ambr 250 high throughput system

Sartorius Stedim Biotech (SSB), a leading international supplier for the biopharmaceutical industry today announced the launch of a new mini bioreactor vessel for its ambr® 250 high throughput (ht) system. This new vessel, which is designed for optimal growth of adherent cells on microcarriers will enable rapid, scalable cell culture process development of vaccines. It will be shown on Booth 47 at the BPI European Summit (April 23-25, 2018) in Amsterdam, The Netherlands.

New mini microcarrier bioreactor for ambr® high throughput system will enable cost-effective, scalable process development of vaccines in cell culture.

The single-use mini bioreactor for microcarrier culture has a working volume of 100-250 mL and features a single Elephant Ear impeller. This impeller type generates optimum mixing and suspension of microcarriers, allowing adherent cells to grow over the entire microcarrier surface. The new mini vessel is based on cell culture bioreactors in the ambr 250 ht system. Utilizing this bioreactor on the ambr 250 ht system will allow rapid scale-up of optimized adherent cell culture processes to SSB’s BIOSTAT® STR range of pilot and manufacturing scale stirred bioreactors. This results in shorter process development timelines than would be achieved by scientists using benchtop bioreactors and spinner flasks.

Simple to set up and use on the ambr 250 ht, this new single-use mini bioreactor minimizes set-up and turnaround time. With up to 24 bioreactors per ambr 250 ht system, the technology is ideal for Design of Experiments (DoE) studies to optimize process development for vaccine manufacturing using a Quality by Design (QbD) approach.

The new vessel has been tested in collaboration with bioprocess experts at Aston University and University College London as part of an Innovate UK funded project. During these studies, all the cell culture parameters were controlled by the ambr 250 ht automated workstation. The results showed that the new microcarrier vessel design enabled growth to confluence of Vero cells on Cytodex microcarriers’ surface.

“There has been increasing interest in using microcarriers for culturing adherent cell lines in single-use stirred bioreactors as they offer a cost-effective alternative to two-dimensional approaches for vaccine production using T-flasks and roller bottles,” stated Dr Barney Zoro, ambr Product Manager at Sartorius Stedim Biotech. “We are proud to be introducing our new ambr 250 mini bioreactor for culturing adherent cells at the BPI European Summit. Scientists visiting us on Booth 47 will find out how they can use our new mini bioreactor as a predictive model to help shorten their process development timelines and reduce their vaccine manufacturing costs.”

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Sartorius. (2019, June 19). Sartorius Stedim Biotech launches mini bioreactor vessel for ambr 250 high throughput system. News-Medical. Retrieved on October 17, 2019 from https://www.news-medical.net/news/20180423/Sartorius-Stedim-Biotech-launches-mini-bioreactor-vessel-for-ambr-250-high-throughput-system.aspx.

  • MLA

    Sartorius. "Sartorius Stedim Biotech launches mini bioreactor vessel for ambr 250 high throughput system". News-Medical. 17 October 2019. <https://www.news-medical.net/news/20180423/Sartorius-Stedim-Biotech-launches-mini-bioreactor-vessel-for-ambr-250-high-throughput-system.aspx>.

  • Chicago

    Sartorius. "Sartorius Stedim Biotech launches mini bioreactor vessel for ambr 250 high throughput system". News-Medical. https://www.news-medical.net/news/20180423/Sartorius-Stedim-Biotech-launches-mini-bioreactor-vessel-for-ambr-250-high-throughput-system.aspx. (accessed October 17, 2019).

  • Harvard

    Sartorius. 2019. Sartorius Stedim Biotech launches mini bioreactor vessel for ambr 250 high throughput system. News-Medical, viewed 17 October 2019, https://www.news-medical.net/news/20180423/Sartorius-Stedim-Biotech-launches-mini-bioreactor-vessel-for-ambr-250-high-throughput-system.aspx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News-Medical.Net.
Post a new comment
Post
You might also like... ×
SSB and Novasep collaborate to develop new membrane chromatography systems