Research finds link between Toxoplasma gondii and lung cancer

Toxoplasma gondii, a microscopic parasite that gets inside our cells, is present in about 10% of the population in the UK.
But in tests on lung cancer patients, all were found to be infected with the parasite.

It's a remarkable result which we don't fully understand yet. It is possible that the presence of the parasite in these patients is exacerbating their symptoms of cancer or interfering with their therapy."

Geoff Hide, Professor of Parasitology, University of Salford

Geoff and Dr Lucy Smyth's work on lung tissue and Chronic Obstructive Pulmonary Disease at Salford University, led them and PhD student Dr Jaro Bajnok to carry out additional tests on the samples to see if any contained Toxoplasma.
Working with Professor Dave Singh, clinical consultant at the Medicines Evaluation Unit at Manchester University, they tested 72 tissue samples from patients diagnosed with lung cancer and found the parasite in all of them.
Further analysis of parasite life-cycle stages suggested that 96% of these patients had active infections. Control samples returned only a 10% positive match, consistent with the national average.
Reporting in the Journal the European Respiratory Journal (Open Research), the team conducted diagnostic tests using five Toxoplasma specific PCR markers and specific immunohistochemistry demonstrated that the infection was present in lung biopsy samples.
T. gondii is capable of infecting virtually all warm-blooded animals, and is commonly acquired by consuming raw meat or infected water or soil or handling cat litter. It can also be transmitted from mother to unborn baby and induce miscarriage.
The Manchester team is now planning a much larger study of samples from a broad range of cancer centers.
"We need to find out why the parasite is so active in these patients. It may be age-related because these are people with lung cancer but that is clearly not the whole story.
"Our advice to clinicians at this stage is 'be aware of the presence of this parasite, do test for it because it may or may not interfere with any treatment regime."
- The same team at Salford, UK found a link between incorrectly functioning cellular pumping mechanism in Cystic Fibrosis patients and Toxoplasma Gondii, reported in Proceedings of the National Academy of Sciences.

Source:

Salford University

Journal reference:

Bajnok, J. et al. (2019) High frequency of infection of lung cancer patients with the parasite Toxoplasma gondii. ERJ Open Research. doi.org/10.1183/23120541.00143-2018

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