Study estimates the burden of dementia among older adults in the U.S.

The first nationally representative study of cognitive impairment in more than 20 years has found that nearly one in 10 U.S. adults over age 65 have dementia.

The study, led by researchers from Columbia University and includes University of Michigan scientists, also found that another 22% have mild cognitive impairment. People with dementia and mild cognitive impairment are more likely to be older, have lower levels of education, and to be racialized as Black or Hispanic. Men and women have similar rates of dementia and mild cognitive impairment.

Although dementia and mild cognitive impairment are known to be common in the United States, accurate, up-to-date measures of their national prevalence were scarce.

“Because the HCAP study is part of the nationally representative and long-running Health and Retirement Study, these data not only show the burden of dementia now, but will be used in the future to track the trends in dementia burden in the decades ahead,” said study co-author Kenneth Langa, the Cyrus Sturgis Professor in the U-M Medical School, a research professor in the Institute for Social Research, and Veterans Affairs Ann Arbor Healthcare System. “Following those trends will be especially important given the likely impact of COVID and other recent population health changes on the risk for dementia in the coming decades.”

The study was published in the journal JAMA Neurology.

Dementia rate 35% among people in their 90s

The study was based on data on 3,500 individuals in the Harmonized Cognitive Assessment Protocol (HCAP) Project, part of U-M's nationally representative Health and Retirement Study (HRS). Between 2016 and 2017, each participant completed a comprehensive set of neuropsychological tests and in-depth interviews, which were used to develop an algorithm for diagnosing dementia or mild cognitive impairment.

Rates of dementia and mild cognitive impairment rose sharply with age: 3% of people between 65 and 69 had dementia, rising to 35% for people aged 90 and over.

Such data are critical for understanding the causes, costs, and consequences of dementia and mild cognitive impairment in the United States, and for informing policies aimed at reducing their impact on patients, families, and public programs.”

Jennifer J. Manly, Study's Lead Author and Professor of Neuropsychology in Neurology at the Gertrude H. Sergievsky Center and the Taub Institute for Research in Aging and Alzheimer's disease at Columbia University

“With increasing longevity and the aging of the Baby Boom generation, cognitive impairment is projected to increase significantly over the next few decades, affecting individuals, families, and programs that provide care and services for people with dementia.”

The economic impact of dementia, including unpaid family caregiving, is estimated to cost $257 billion per year in the United States and $800 billion worldwide.

Disparities in cognitive impairment are driven by exposure to structural and social inequalities

Unlike previous large studies of dementia in the United States, participants in the new study are representative of older adults, and the researchers could examine differences in the national prevalence of dementia and mild cognitive impairment by age, race and ethnicity, gender and education.

The data show a disproportionate burden of dementia among older adults who self-identified as Black or African American, of mild cognitive impairment among older adults who identify as Hispanic, and both categories of cognitive impairment among people who had fewer opportunities to obtain education.

David Weir, a research professor at ISR's Survey Research Center, is the principal investigator of the HRS, and co-author of the current study.

“Large, diverse and nationally representative population studies are essential to identifying the kinds of disparities shown here,” Weir said. “This study caps over a decade of development of methods to bring robust diagnostic tools out of the clinic and into the population.”

Langa is the principal investigator of the HCAP study. Weir and Langa are co-principal investigators of the HCAP International Network. Langa, Weir and collaborators developed the HCAP protocol prior to implementing it in the U.S. in 2016 as part of the HRS.

The HRS HCAP project is also part of an international network of studies on dementia using the same study protocol to collect comparable data on dementia in 15 countries around the world. This will allow researchers to gauge and compare the burden of dementia in low-, middle-, and high-income countries now and into the next decade.

The other contributors are: Richard N. Jones (Brown University Warren Alpert Medical School); Lindsay H. Ryan, Ryan McCammon and Steven G. Heeringa (University of Michigan); and Deborah A. Levine (University of Michigan and Veterans Affairs Center for Clinical Management Research, Ann Arbor).

Source:
Journal reference:

Manly, J.J., et al. (2022) Estimating the Prevalence of Dementia and Mild Cognitive Impairment in the US. The 2016 Health and Retirement Study Harmonized Cognitive Assessment Protocol Project. JAMA Neurology. doi.org/10.1001/jamaneurol.2022.3543.

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