Women with post-acute sequelae of COVID-19 could be at greater risk of developing hypertension

Post-acute sequelae of COVID-19 (PASC), colloquially referred to as long COVID-19 or long COVID, is when someone recovers from acute COVID-19 but shows a cluster of symptoms for months afterward. New research sheds light on the effects of long COVID on the cardiovascular system. The study is published in the American Journal of Physiology-Heart and Circulatory Physiology. It was chosen as an APSselect article for June.

"Collectively, these findings suggest that females with PASC could be at greater risk of developing hypertension, which appears independent of symptom burden."

Between 10 and 20 percent of people who develop COVID-19 experience some symptoms of long COVID, such as fatigue, brain fog and shortness of breath. Long COVID is more prevalent in women.

In the current study, researchers collected a variety of detailed cardiovascular measures from 12 women with long COVID and 11 healthy women (controls) matched for age, height, weight and body mass index. In addition, the long COVID participants answered a questionnaire about the nature and severity of their ongoing symptoms.

The vascular function measures made in the limbs and brain of the two groups did not differ significantly. However, the long COVID group had significantly higher resting blood pressure when measured from the arm while lying quietly, and also higher central arterial stiffness. However, the severity of blood pressure elevation and arterial stiffness did not correlate to the severity of symptoms long COVID participants reported in the questionnaire.

The researchers noted that while only one participant with long COVID had been diagnosed with hypertension prior to contracting COVID-19, "two patients had received a new diagnosis of hypertension post-COVID-19, two had resting [blood pressure] values classified as Stage II hypertension, one as Stage I hypertension and two with high [blood pressure] based on the current guidelines." The elevation in resting blood pressure was consistent.

Conversely, though 11 of the 12 people in the long COVID group reported experiencing brain fog, they did not show signs of cerebral vascular dysfunction-;indicating that the cause of that common symptom lies elsewhere.

"It is possible that the greater prevalence of PASC could worsen the already existing higher burden of hypertension in older females," warn researchers.

Journal reference:

Nandadeva, D., et al. (2023) Cardiovascular and cerebral vascular health in females with postacute sequelae of COVID-19. American Journal of Physiology-Heart and Circulatory Physiology. doi.org/10.1152/ajpheart.00018.2023.


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