Study sheds new light on the links between infections with inflammation and empathy for pain

When people are ill, they feel less empathy for others than when they are healthy. This has been confirmed by a study conducted by Ruhr University Bochum and the University of Duisburg-Essen, Germany. The researchers investigated "sickness behavior", a process in which the body reorganizes its biological priorities in the context of an acute infection. So far, it has mainly been researched in connection with social withdrawal and feelings of social disconnection. But how does illness affect our empathy? The current study sheds new light on the links between infections with inflammation in the body and the ability to empathize with the pain of others. The team from Bochum and Essen, which is cooperating as part of the University Alliance Ruhr, published its findings on March 28, 2024 in the journal "Brain, Behavior, and Immunity".

Induced infection through administration of bacterial endotoxin

Experimentally, the various facets of sickness behavior can be induced by the administration of bacterial endotoxin, in short LPS for lipopolysaccharide. The researchers from Bochum and Essen made use of this mechanism. They administered a low dose of LPS or - as a placebo - an injection with physiological saline to 52 voluntary female participants. The women were then asked to rate various social interactions. They were shown pictures of women who were either in somatic or psychological pain or in an emotionally neutral interaction with a male counterpart.


The results surprised us. While the empathy for somatic pain was largely the same in the LPS and placebo group, there was a significant reduction in empathy for psychological pain in the test subjects exposed to LPS."

Vera Flasbeck, first author from the LWL-University Hospital Bochum

In the study, acute inflammation thus led to a reduction in people's empathy for the psychological pain of others.

Results with socio-political relevance

"We assume that the reduced empathy serves to save energy in terms of social engagement in periods of illness," explains Prof. Dr. Martin Brüne from the LWL-University Hospital Bochum, who supervised the study together with Professors Manfred Schedlowski and Harald Engler from the Institute of Medical Psychology and Behavioral Immunobiology at the Faculty of Medicine of the University of Duisburg-Essen.

"The results of the study indicate that inflammation - as in the case of physical infections, for instance - affects both our physical health and our interpersonal relationships." Schedlowski adds that the topic may have general interest, especially considering the recent COVID-19 pandemic: "The results may have socio-political relevance. For example, how does a general feeling of illness affect decision-making, for example in relation to political decisions?"

And another aspect has sparked the research interest of the cross-university team. Previous studies have shown that individuals with infectious diseases are avoided by members of the social group, but are sometimes also cared for. "This behavior presumably depends on the degree of the relationship," say Brüne and Schedlowski. "Accordingly, it would be highly interesting to carve out in future studies the differences in empathy for psychological and somatic pain in relation to attachment and familiarity."

Research cooperation as part of the University Alliance Ruhr

The research cooperation between Bochum and Essen took place as part of the University Alliance Ruhr (UA Ruhr). Since 2007, the three Ruhr region universities have been engaged in close strategic cooperation under this umbrella. By pooling their strengths, the partner institutions are systematically expanding their output. There are now over 100 cooperations in the fields of research, teaching and administration, all built on the principle of being "better together". With over 120,000 students and almost 1,300 professors, the UA Ruhr is one of the largest and best-performing hubs for science and technology in Germany.


The publication was funded by the FoRUM research funding of the Faculty of Medicine of Ruhr University Bochum and the Collaborative Research Centers SFB 1280 and SFB/TRR 289 of the German Research Foundation.

Journal reference:

Flasbeck, V., et al. (2024). Acute experimental inflammation in healthy women attenuates empathy for psychological pain. Brain, Behavior, and Immunity.


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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