In the management of critically ill neonates, measurement of arterial oxygenation is frequently required to prevent hypoxia or hyperoxia. Hypoxia may lead to pulmonary vasoconstriction and pulmonary hypertension. In addition, the resulting alterations in systemic blood flow may lead to neurologic and other organ damage. Hyperoxia is associated with oxygen free radical production, which may cause cellular and tissue damage. In neonatology, the most common example of this process is seen in preterm infants with immature retinal vascularization. Hyperoxia has been associated with damage to the retina, resulting in the retinopathy of prematurity.
Oxygen supplementation is critical to the survival of many infants with respiratory disease. In the neonatal intensive care unit (NICU), when oxygen therapy is used alone or in addition to other supportive therapies (such as mechanical ventilation, surfactant replacement therapy, or inhaled nitric oxide), there is a risk of rapid change in the patient’s oxygen saturation, requiring an immediate response from the clinician. An effective method for monitoring arterial oxygenation levels continuously in these patients is a high priority
Daniele De Luca (MD,PhD)
Associate Professor of Neonatology
Chef de Service - Medical Director
Pediatrie et Reanimation Neonatale - Pediatrics and Neonatal Critical Care
GH Paris Sud - South Paris University Hospitals, "A.Beclere" Medical Center