The tri-culture model is a unique approach to assessing the functional and morphological effects on cardiac cells.
Image Credit: Molecular Devices
Recent studies have shown that tri-cellular co-culture microtissues of cardiomyocytes, endothelial cells, and cardiac fibroblasts derived from human iPSCs improve cell maturation and functional activity compared to 2D cardiomyocytes, more closely mimicking actual heart physiology.
This app note discusses the usability and biological significance of employing iPSC-derived cell types in 3D micro-tissues as a potential model for assessing chemical effects on human cardiac tissues in a high-throughput format.
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About Molecular Devices UK Ltd
Molecular Devices is one of the world’s leading providers of high-performance bioanalytical measurement systems, software and consumables for life science research, pharmaceutical and biotherapeutic development. Included within a broad product portfolio are platforms for high-throughput screening, genomic and cellular analysis, colony selection and microplate detection. These leading-edge products enable scientists to improve productivity and effectiveness, ultimately accelerating research and the discovery of new therapeutics. Molecular Devices is committed to the continual development of innovative solutions for life science applications. The company is headquartered in Silicon Valley, California, with offices around the globe. For more information, please visit www.moleculardevices.com.
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