The allelic composition of an individual's apolipoprotein (ApoE) can significantly impact the risk of developing Alzheimer's disease.
Image Credit: Molecular Devices
People with two copies of the E4 allele (ApoE4/4) have a ~65% chance of developing Alzheimer's disease (AD) by age 85, compared to only 10% in people with both wild-type E3 alleles.
This remarkable difference establishes ApoE4 as a significant genetic risk factor for Alzheimer's disease and emphasizes its role in disease pathogenesis.
This app note shows how to replicate Alzheimer's disease in iPSC-derived neurons modified with ApoE allelic variations (E2/2, E3/3, and E4/4).
This biological system of 3D neurospheres and a detailed examination of calcium oscillations offer a potential and informative tool for disease modeling and phenotypic functional evaluation, which can be applied to compound testing.
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About Molecular Devices UK Ltd
Molecular Devices is one of the world’s leading providers of high-performance bioanalytical measurement systems, software and consumables for life science research, pharmaceutical and biotherapeutic development. Included within a broad product portfolio are platforms for high-throughput screening, genomic and cellular analysis, colony selection and microplate detection. These leading-edge products enable scientists to improve productivity and effectiveness, ultimately accelerating research and the discovery of new therapeutics. Molecular Devices is committed to the continual development of innovative solutions for life science applications. The company is headquartered in Silicon Valley, California, with offices around the globe. For more information, please visit www.moleculardevices.com.
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