HPSC-derived neural organoids can help scientists better understand brain development, disorders, and diseases in the context of different genetic origins.
Image Credit: Molecular Devices
The study investigates using 3D neural organoids made from human pluripotent stem cells (hPSCs) to assess neurotoxicity and neural function.
Organoids were imaged to measure spontaneous calcium oscillations, which provided insights into brain function.
The study emphasizes the advantages of high-throughput screening, automated monitoring, and the ability to test several compounds to demonstrate the potential of this advanced model for drug testing and understanding brain function.
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