Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Lymphoid depletion associated with suppressed APC function characterizes the lethality of COVID-19 in mice

Individuals who are immunocompromised are considered at higher risk for severe or longer disease with COVID-19. Understanding the systemic immune response is vital for research efforts to reduce its effects on multiple organs.

2 Jun 2023

Sleep-disordered breathing in cognitively unimpaired amyloid-positive individuals may exacerbate neurodegeneration in medial temporal lobe subregions

A new study investigated the link between SDB severity and the volume of medial temporal lobe (MTL) substructures. In addition, it also evaluated the association between SDB and MTL subregions volumes with episodic memory performance.

2 Jun 2023

Innovative approach for detecting pre-cancerous lesions using large, high-res images

A new study presents an innovative approach to the crucial detection of pre-cancerous lesions using large, high-res images.

1 Jun 2023

RNA regulatory mechanism could be targeted to slow AD progression mediated by stress granules

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 10, entitled, "Stress granules sequester Alzheimer's disease-associated gene transcripts and regulate disease-related neuronal proteostasis."

1 Jun 2023

St. Jude researchers discover NLRP12 as a direct bridge from hemolysis to inflammatory disease

Infections and other diseases can cause red blood cells to rupture, releasing the oxygen-binding molecule hemoglobin, which breaks down into heme.

1 Jun 2023

CardioGen upgrade facilitates more accurate diagnosis of monogenic cardiovascular diseases

Over 2,800 cases, representing a 31% increase, added to BGI Genomics-led CardioGen's hereditary cardiovascular disease gene data.

From BGI Genomics 1 Jun 2023

Moderate-protein diet improves metabolic health in both young and middle-aged mice

Consuming nutritious food can improve metabolic health and delay aging. But what are the appropriate quantities of dietary macronutrients that can help achieve this? To answer this, researchers from Japan fed isocaloric diets with varying amounts of protein to young and middle-aged male mice.

31 May 2023

Environmental enrichment may reduce early accumulation of amyloid plaques in Alzheimer's mouse model

About two-thirds of the risk for Alzheimer's disease (AD) is thought to arise from genetic influences, but about a third could be influenced by environment and lifestyle, opening the door for behavioral interventions that could delay or prevent pathophysiological changes that occur with AD.

31 May 2023

The immunopathology of post-acute sequelae of SARS-CoV-2 infection: highlighting the knowledge gaps

The immunopathology of post-acute sequelae of SARS-CoV-2 infection (PASC).

31 May 2023

Biomarker study reveals the effects of astrocyte reactivity in preclinical Alzheimer's disease

Evidence supports a close link between Aβ, astrocyte reactivity, and tau pathology in preclinical AD.

31 May 2023

New method may help identify the essential ingredients for making an effective HIV vaccine

Since it was identified in 1984 as the cause of Acquired Immune Deficiency Syndrome (AIDS), the human immunodeficiency virus (HIV) has infected more than 80 million people and been responsible for some 40 million deaths worldwide, according to the World Health Organization (WHO).

30 May 2023

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

To commemorate World Multiple Sclerosis (MS) Day, we speak to Dr. Cameron McAlpine about his latest research that sought to understand better the proteins and signals that act as messengers between brain and immune cells in MS.

30 May 2023

New research shows astrocytes are key to swaying the pendulum in Alzheimer's disease progression

Why do some people develop Alzheimer's disease while others don't? And, even more puzzlingly, why do many individuals whose brains are chock-full of toxic amyloid aggregates - a telltale sign of Alzheimer's brain pathology - never go on to develop Alzheimer's-associated dementias?

29 May 2023

Study identifies a novel druggable signaling molecule involved in obesity and diabetes

More than 40% of Americans are considered obese, and the trend continues to grow. The treatments or preventive options for obesity and obesity-associated diseases are limited.

26 May 2023

Curcumin can suppress metastasis of colorectal cancer cells by activating a specific signaling pathway

LMU researchers have identified a signaling pathway via which curcumin can suppress the metastasis of colorectal cancer cells.

25 May 2023

Case study: Experimental lecanemab treatment causes adverse outcomes in 65-year-old woman with Alzheimer's disease

In a noteworthy case study published in the Journal of Alzheimer's Disease investigators report autopsy findings in a 65-year-old woman with Alzheimer's disease (AD) who received three open label infusions of the experimental anti-amyloid beta (Aβ) antibody drug lecanemab.

25 May 2023

Genetic predisposition to lipids, Alzheimer’s and heart disease in MLXIPL gene shaped by exogenous exposures

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 9, entitled, "Exogenous exposures shape genetic predisposition to lipids, Alzheimer's, and coronary heart disease in the MLXIPL gene locus."

25 May 2023

The first thousand days of development

Study provides a bird's-eye view of the significant moments of the first thousand days of life.

25 May 2023

Superior cognition in individuals who are 90+ associated with resilience to neurodegenerative pathologies

A University of California, Irvine-led team of researchers have discovered that the oldest-old, those who live to be 90+ and have superior cognitive skills, have similar levels of brain pathology as Alzheimer's patients, however, they also have less brain pathology of other neurodegenerative diseases that cause memory and thinking problems.

25 May 2023

Manipulating a signaling protein to slow down muscular dystrophy

A team of researchers at the University of Houston College of Pharmacy is reporting that by manipulating TAK1, a signaling protein that plays an important role in development of the immune system, they can slow down disease progression and improve muscle function in Duchenne muscular dystrophy (DMD).

25 May 2023

Pathology News and Research

Further Reading

Lymphoid depletion associated with suppressed APC function characterizes the lethality of COVID-19 in mice

Sleep-disordered breathing in cognitively unimpaired amyloid-positive individuals may exacerbate neurodegeneration in medial temporal lobe subregions

Innovative approach for detecting pre-cancerous lesions using large, high-res images

RNA regulatory mechanism could be targeted to slow AD progression mediated by stress granules

St. Jude researchers discover NLRP12 as a direct bridge from hemolysis to inflammatory disease

CardioGen upgrade facilitates more accurate diagnosis of monogenic cardiovascular diseases

Moderate-protein diet improves metabolic health in both young and middle-aged mice

Environmental enrichment may reduce early accumulation of amyloid plaques in Alzheimer's mouse model

The immunopathology of post-acute sequelae of SARS-CoV-2 infection: highlighting the knowledge gaps

Biomarker study reveals the effects of astrocyte reactivity in preclinical Alzheimer's disease

New method may help identify the essential ingredients for making an effective HIV vaccine

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

New research shows astrocytes are key to swaying the pendulum in Alzheimer's disease progression

Study identifies a novel druggable signaling molecule involved in obesity and diabetes

Curcumin can suppress metastasis of colorectal cancer cells by activating a specific signaling pathway

Case study: Experimental lecanemab treatment causes adverse outcomes in 65-year-old woman with Alzheimer's disease

Genetic predisposition to lipids, Alzheimer’s and heart disease in MLXIPL gene shaped by exogenous exposures

The first thousand days of development

Superior cognition in individuals who are 90+ associated with resilience to neurodegenerative pathologies

Manipulating a signaling protein to slow down muscular dystrophy

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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