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Phase 2 clinical trial launched in Thailand to evaluate IL-15 agonist as therapy to reduce HIV reservoir

The U.S. Military HIV Research Program (MHRP) at the Walter Reed Army Institute of Research last week launched a Phase 2 clinical trial in Thailand to evaluate an interleukin-15 (IL-15) superagonist, ImmunityBio's Anktiva (also called N-803), administered during acute HIV infection as an experimental therapy to target establishment of the HIV reservoir at a very early stage.

8 Apr 2021

IRB Barcelona researchers find the Achilles heel of some lung tumors

In cancer, personalized medicine takes advantage of the unique genetic changes in an individual tumor to find its vulnerabilities and fight it.

8 Apr 2021

Eliminating racism and anti-LGBTQ policies can improve the health of black sexual minority men

Eliminating racist and anti-LGBTQ policies is essential to improving the health of Black gay, bisexual and other sexual minority men, according to a Rutgers-led research team.

8 Apr 2021

The interaction between blood clotting and SARS-CoV-2 infection

Coagulopathy - a condition in which the blood's ability to clot is impaired, is recognized as a significant aspect of morbidity in COVID-19 patients. In a recent study, Prof Lewis Cantley and a team of researchers explored the role of coagulation factors in the SARS-CoV-2 infection. Their recent study is posted on the bioRxiv server.

7 Apr 2021

The GovLab, AFD and Expertise France select 7 projects to address COVID-19 challenges in Africa

Out of a field of over 80 proposals by organizations in Africa -- many working in collaboration -- The Governance Lab (GovLab) at the NYU Tandon School of Engineering, L'Agence Francaise de Developpement (AFD), and Expertise France chose seven projects to receive the #Data4COVID19 Africa Challenge.

7 Apr 2021

Novel hydrogel-based vaccine formulation shows high efficacy against SARS-CoV-2

A fascinating new preprint research paper posted to the bioRxiv* server discusses impressively high neutralizing responses elicited with a single dose of a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine formulation, which could help turn the tide of the current pandemic if validated.

6 Apr 2021

Vaccine nationalism reinforces inequities in access and exacerbates health disparities

While the U.S. has begun to vaccinate millions of Americans each day, COVID-19 vaccine supplies around the world remain scarce.

5 Apr 2021

Vermont to give minority residents vaccine priority

States have tried with limited success to get covid vaccines to people of color, who have been disproportionately killed and hospitalized by the virus.

5 Apr 2021

FIND announces launch of a request for proposals to expand access to COVID-19 testing services

The Foundation for Innovative New Diagnostics (FIND) announced today the launch of a request for proposals (RFP) to accelerate the development, manufacturing, and market availability of accurate, affordable, quality-assured and easy-to-use SARS-CoV-2 self-tests for use in low- and middle-income countries (LMICs).

5 Apr 2021

New approach to CAR T gene therapy yields efficient and longer-lasting response against HIV

A UCLA research team has shown that using a truncated form of the CD4 molecule as part of a gene therapy to combat HIV yielded superior and longer-lasting results in mouse models than previous similar therapies using the CD4 molecule.

3 Apr 2021

Study shows decline in subarachnoid hemorrhage hospitalizations during COVID-19 pandemic

New research led by investigators from Boston Medical Center and Grady Memorial Hospital demonstrates the significant decline in hospitalizations for neurological emergencies during the COVID-19 pandemic.

2 Apr 2021

Africa's health systems are failing to meet the needs of vulnerable groups

Less than half the population of Africa are not receiving the health services they need, with vulnerable groups including gay and disabled people left behind, says a report.

31 Mar 2021

Male fetuses impair the maternal and placental immune response to SARS-CoV-2 infection in pregnancy, finds study

The ongoing COVID-19 pandemic, caused by SARS-CoV-2, is now established to be more likely to lead to symptomatic and serious illness in males relative to females. This may extend as far back as pregnancy, suggests a recent study.

31 Mar 2021

Researchers identify factors linked to poor outcomes in patients with childhood-onset lupus

UT Southwestern researchers have identified factors that put patients with childhood-onset lupus at elevated risk for poor outcomes, such as end-stage renal disease or death, as they transition from pediatric to adult health care.

30 Mar 2021

Arginine methylation important in SARS-CoV-2 viral replication

Researchers show that methylation of arginine in the virus nucleocapsid protein controls the protein's functions and plays a role in the life cycle of the SARS-CoV-2 virus.

29 Mar 2021

FDA-approved cancer drug blunts SARS-CoV-2 protein's detrimental effects

University of Maryland School of Medicine (UMSOM) researchers have identified the most toxic proteins made by SARS-COV-2 - the virus that causes COVID-19 – and then used an FDA-approved cancer drug to blunt the viral protein's detrimental effects. In their experiments in fruit flies and human cell lines, the team discovered the cell process that the virus hijacks, illuminating new potential candidate drugs that could be tested for treating severe COVID-19 disease patients.

29 Mar 2021

GlyNAC could improve many age-associated defects in older humans

A pilot human clinical trial conducted by researchers at Baylor College of Medicine reveals that supplementation with GlyNAC - a combination of glycine and N-acetylcysteine as precursors of the natural antioxidant glutathione - could improve many age-associated defects in older humans to improve muscle strength and cognition, and promote healthy aging.

29 Mar 2021

Diabetes drug appears to exploit vulnerability of AIDS-causing retrovirus HIV

A team led by scientists at the UNC School of Medicine discovered an important vulnerability of the AIDS-causing retrovirus HIV, and has shown in preclinical experiments that a widely used diabetes drug, metformin, seems able to exploit this vulnerability.

29 Mar 2021

Researchers identify new drug candidates for treating patients with severe COVID-19

University of Maryland School of Medicine (UMSOM) researchers have identified the most toxic proteins made by SARS-COV-2--the virus that causes COVID-19 - and then used an FDA-approved cancer drug to blunt the viral protein's detrimental effects.

27 Mar 2021

‘Incredibly concerning’ lawsuit threatens no-charge preventive care for millions

With a challenge to the Affordable Care Act still pending at the Supreme Court, conservatives are continuing to launch legal attacks on the law, including a case in which a Texas federal judge seems open to ending the requirement that most Americans must receive preventive services like mammograms free of charge.

26 Mar 2021

HIV News and Research

Phase 2 clinical trial launched in Thailand to evaluate IL-15 agonist as therapy to reduce HIV reservoir

IRB Barcelona researchers find the Achilles heel of some lung tumors

Eliminating racism and anti-LGBTQ policies can improve the health of black sexual minority men

The interaction between blood clotting and SARS-CoV-2 infection

The GovLab, AFD and Expertise France select 7 projects to address COVID-19 challenges in Africa

Novel hydrogel-based vaccine formulation shows high efficacy against SARS-CoV-2

Vaccine nationalism reinforces inequities in access and exacerbates health disparities

Vermont to give minority residents vaccine priority

FIND announces launch of a request for proposals to expand access to COVID-19 testing services

New approach to CAR T gene therapy yields efficient and longer-lasting response against HIV

Study shows decline in subarachnoid hemorrhage hospitalizations during COVID-19 pandemic

Africa's health systems are failing to meet the needs of vulnerable groups

Male fetuses impair the maternal and placental immune response to SARS-CoV-2 infection in pregnancy, finds study

Researchers identify factors linked to poor outcomes in patients with childhood-onset lupus

Arginine methylation important in SARS-CoV-2 viral replication

FDA-approved cancer drug blunts SARS-CoV-2 protein's detrimental effects

GlyNAC could improve many age-associated defects in older humans

Diabetes drug appears to exploit vulnerability of AIDS-causing retrovirus HIV

Researchers identify new drug candidates for treating patients with severe COVID-19

‘Incredibly concerning’ lawsuit threatens no-charge preventive care for millions

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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