Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

HKU-developed antibiotic drug to enter clinical trials in Mainland China

A new antibiotic drug developed by a research team led by Professor Li Xuechen from the Department of Chemistry at The University of Hong Kong (HKU) has recently gained approval from the authorities to undergo clinical trials in the Mainland.

10 Oct 2023

IU Cancer Center awarded grant to train next generation of cancer drug discovery researchers

The Indiana University Melvin and Bren Simon Comprehensive Cancer Center was awarded a prestigious grant to train the next generation of cancer drug discovery and development researchers.

10 Oct 2023

Drug Discovery 2023: A Conversation with Professor Janet Hemingway

We spoke to Professor Janet Hemingway, founding Director of iiCON and Professor of Tropical Medicine at Liverpool School of Tropical Medicine.

9 Oct 2023

UK's first-of-its-kind total-body PET imaging platform could enhance quality and speed of drug discovery

A partnership between Medicines Discovery Catapult (MDC), the Medical Research Council (MRC) and Innovate UK will deliver scientific breakthroughs with the launch of the UK's first-of-its-kind national total-body positron emission tomography (PET) imaging platform for drug discovery

9 Oct 2023

Researchers spearhead a new method to hone in on new cancer drug targets

Searching for new ways to block the growth of cancer cells is like looking for a needle in a haystack. Tumor cells rely on thousands of proteins to function, but only a few of those proteins can be precisely targeted by drugs to treat cancer safely and effectively.

5 Oct 2023

Ubiquigent collaborates with Imperial College London on DUB probe discovery to facilitate preclinical and clinical target engagement studies

Ubiquigent Limited (Ubiquigent), a drug discovery and development company harnessing novel deubiquitinase (DUB) modulators as new therapeutics for areas of high unmet medical need, today announced it is supporting a PhD student in the Institute of Chemical Biology EPSRC Centre for Doctoral Training (CDT) in Chemical Biology, at Imperial College London.

From Ubiquigent Limited 4 Oct 2023

AI tool PARMESAN predicts drug-gene interactions for genetic disorders

To discover new treatments for genetic disorders, scientists need a thorough knowledge of prior literature to determine the best gene/protein targets and the most promising drugs to test.

3 Oct 2023

IU cancer researcher receives NCI grant to examine how immune cells support breast cancer development

A breast cancer researcher at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center received a five-year, $2.2 million grant from the National Cancer Institute to examine how certain immune cells support metastatic breast cancer development-;and how to stop it.

3 Oct 2023

Start Codon invites life sciences leaders, founders, and investors to Innovation Showcase 2023

Start Codon is pleased to invite life sciences people from across the life science and biotech industries to attend their Innovation Showcase 2023.

From Start Codon Ltd 2 Oct 2023

Optibrium releases powerful metabolism prediction capability in next generation StarDrop software

Optibrium, a leading developer of software and AI solutions for drug discovery, today launched the latest version of its drug discovery platform, StarDrop.

From Optibrium Ltd. 2 Oct 2023

New CRISPR-based gene-editing tool could lead to better treatments for genetic disorders

A new CRISPR-based gene-editing tool has been developed which could lead to better treatments for patients with genetic disorders.

29 Sep 2023

Extending FDA-approved cancer drug indications requires high patient numbers, study finds

Number of patient participants needed for secondary approval of a new cancer drug.

29 Sep 2023

Aerosolized ACE2 neutralizes COVID-19 variants in lab and mice tests

Researchers from the University of Texas Southwestern have developed an aerosolized, mutated form of ACE2 that effectively neutralizes various SARS-CoV-2 variants in both cell cultures and mice. The study suggests that this modified ACE2 has promising preventive and therapeutic potential against COVID-19, especially with its easy aerosolized administration.

28 Sep 2023

Unlocking the code: BigRNA's deep learning model predicts RNA behavior

Researchers have developed BigRNA, a groundbreaking deep learning model capable of predicting RNA behavior, including tissue-specific expression and splicing, directly from genomic DNA sequences. The model excels in identifying pathogenic variants and could be a game-changer in the development of personalized RNA-based therapies for treating genetic diseases.

28 Sep 2023

Newly identified stem cell variants drive inflammation in cystic fibrosis patients

Two nationally recognized experts in cloning and stem cell science from the University of Houston, Wa Xian and Frank McKeon, are reporting that five lung stem cell variants dominate the lungs of patients with advanced cystic fibrosis (CF), and that these variants drive key aspects of CF pathology including inflammation, fibrosis and mucin secretion.

28 Sep 2023

Arrayed CRISPR Screening for Revolutionizing Target Discovery

In this interview conducted at SLAS EU 2023 in Brussels, Belgium, we spoke to Ulrike Kuenzel, Associate Director in the Functional Genomics department at AstraZeneca about the application of arrayed CRISPR screening for target identification and more.

From Society for Laboratory Automation and Screening (SLAS) 27 Sep 2023

SRI spins off a biosciences platform that accelerates drug discovery

SRI International announced today it is spinning off Synfini, a biosciences platform that accelerates the process by which pharmaceutical and other companies can design, synthesize, and bring to market molecules for drug development.

26 Sep 2023

Research presents new approach to identify therapeutic targets for human diseases associated with protein phase separation

Recent research demonstrates that protein phase separation (PPS) is widely present in cells and drives a variety of important biological functions.

25 Sep 2023

Machine learning speeds up virtual drug screening by 10-fold

Boosting virtual screening with machine learning allowed for a 10-fold time reduction in the processing of 1.56 billion drug-like molecules. Researchers from the University of Eastern Finland teamed up with industry and supercomputers to carry out one of the world's largest virtual drug screens.

22 Sep 2023

Weill Cornell Medicine receives NIH grant to lead a national contraceptive research center

Weill Cornell Medicine has received a three-year, nearly $6 million grant to lead one of three national contraceptive research centers.

21 Sep 2023

Drug Discovery News and Research

Further Reading

HKU-developed antibiotic drug to enter clinical trials in Mainland China

IU Cancer Center awarded grant to train next generation of cancer drug discovery researchers

Drug Discovery 2023: A Conversation with Professor Janet Hemingway

UK's first-of-its-kind total-body PET imaging platform could enhance quality and speed of drug discovery

Researchers spearhead a new method to hone in on new cancer drug targets

Ubiquigent collaborates with Imperial College London on DUB probe discovery to facilitate preclinical and clinical target engagement studies

AI tool PARMESAN predicts drug-gene interactions for genetic disorders

IU cancer researcher receives NCI grant to examine how immune cells support breast cancer development

Start Codon invites life sciences leaders, founders, and investors to Innovation Showcase 2023

Optibrium releases powerful metabolism prediction capability in next generation StarDrop software

New CRISPR-based gene-editing tool could lead to better treatments for genetic disorders

Extending FDA-approved cancer drug indications requires high patient numbers, study finds

Aerosolized ACE2 neutralizes COVID-19 variants in lab and mice tests

Unlocking the code: BigRNA's deep learning model predicts RNA behavior

Newly identified stem cell variants drive inflammation in cystic fibrosis patients

Arrayed CRISPR Screening for Revolutionizing Target Discovery

SRI spins off a biosciences platform that accelerates drug discovery

Research presents new approach to identify therapeutic targets for human diseases associated with protein phase separation

Machine learning speeds up virtual drug screening by 10-fold

Weill Cornell Medicine receives NIH grant to lead a national contraceptive research center

Drug Discovery - Second Edition eBook

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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