Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

Muscle-repairing macrophages trigger heterotopic ossification in mice

We have identified a macrophage population "Mrep" that plays an essential role in muscle repair. However, in Fibrodysplasia ossificans progressiva (FOP), Mrep functions as a pathogenic cell that triggers heterotopic ossification.

18 Mar 2026

Expert consensus validates UDFF for noninvasive fatty liver assessment

As the global burden of obesity, type 2 diabetes, and metabolic syndrome continues to rise, fatty liver disease has become one of the most prevalent chronic liver conditions worldwide. Its progressive forms, including metabolic dysfunction‐associated steatohepatitis (MASH), cirrhosis, and hepatocellular carcinoma, now represent a major public health challenge.

17 Mar 2026

Routine care gap leaves metabolic acidosis undetected in chronic kidney disease

A Japanese registry has identified a blind spot in the routine care of patients with chronic kidney disease (CKD). Serum bicarbonate levels are rarely measured, leaving metabolic acidosis largely undetected and hence, undertreated.

16 Mar 2026

Researchers identify cellular drivers of gut scarring in Crohn’s disease

As inflamed regions of the gut form scar tissue, the space within the gut lumen becomes smaller and more restricted, leading to symptoms of gut obstruction.

16 Mar 2026

Adding three simple amino acids boosts mRNA and CRISPR delivery

Lipid nanoparticles, or LNPs, best known as the delivery vehicle for the COVID-19 mRNA vaccines received by billions of people, are now at the center of a much larger medical revolution.

12 Mar 2026

As lung disease threatens workers, lawmakers seek protections for countertop manufacturers

César Manuel González, 37, used to work with stone that was engineered to endure: dense, polished slabs designed to outlast the kitchens in which they were installed.

12 Mar 2026

MUSC’s new manual for navigating dementia

For an estimated 11% of Americans over age 65 who have dementia and the over 11 million unpaid caregivers supporting them, there is no instruction manual for navigating life after diagnosis. A team of College of Nursing researchers at the Medical University of South Carolina is working to fill that gap.

12 Mar 2026

p38 MAPK drives epigenetic activation of fibrotic genes in lung fibroblasts

A new research paper was published in Volume 18 of Aging-US on March 3, 2026, titled "P38 MAPK is involved in epigenetic regulation of fibrotic genes in replication induced senescence in lung fibroblasts."

10 Mar 2026

EVA1A regulates fatty acid transporter CD36 in fatty liver disease

Metabolic Dysfunction-Associated Steatotic Liver Disease（MASLD） is characterized by excessive accumulation of lipids in hepatocytes and is closely associated with the rapid rise in insulin resistance, obesity, and diabetes prevalence, making it one of the most common chronic liver diseases worldwide.

9 Mar 2026

Women face higher liver fibrosis risk from cardiometabolic factors than men

Women with certain cardiometabolic risk factors, including type 2 diabetes and high waist circumference, face a greater increase in risk for liver fibrosis than men with the same risk factors.

9 Mar 2026

Cellular roadmap offers new targets for improving rotator cuff surgical repair

Rotator cuff tears are among the most common and debilitating musculoskeletal injuries, frequently causing chronic pain, reduced shoulder mobility, and a high risk of re-injury even after surgical repair.

9 Mar 2026

New compound shows promise in protecting the liver from damage after small bowel surgery

When parts of the small intestine are diseased or die, the treatment can involve surgically removing the affected tissue.

6 Mar 2026

Six federal scientists run out by Trump talk about the work left undone

Marc Ernstoff, a physician who has pioneered immunotherapy research and treatments for cancer patients, said his work as a federal scientist proved untenable under the Trump administration.

6 Mar 2026

Repurposed kidney drug finerenone shows promise in treating premature ovarian insufficiency

Premature ovarian insufficiency (POI) is a clinically significant cause of infertility that affects between 1 to 3% of women of childbearing age.

5 Mar 2026

New fragmentome technology can detect early liver fibrosis and cirrhosis

Researchers at the Johns Hopkins Kimmel Cancer Center report that an artificial intelligence (AI)-based liquid biopsy test using genome-wide cell-free DNA (cfDNA) fragmentation patterns and repeat landscapes can detect early liver fibrosis and cirrhosis, and may also reveal signals of broader chronic disease burden.

4 Mar 2026

How are GLP-1 drugs reshaping treatment for obesity, diabetes, and heart disease?

A comprehensive Lancet review synthesizes evidence from major clinical trials showing that GLP-1 receptor agonists and next-generation incretin therapies deliver substantial weight loss while reducing cardiovascular and kidney risks. Emerging dual, triple, and oral agents may further expand treatment options and improve outcomes across obesity, type 2 diabetes, and related metabolic diseases.

3 Mar 2026