Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

Researchers develop bioactive peptide with therapeutic and regenerative potential

Since the COVID-19 pandemic, global interest in antiviral therapies has increased significantly. Recently, with the growing attention to peptide-based drugs such as Wegovy, demand for effective peptide therapeutics derived from natural substances is rapidly rising.

28 May 2025

Study sheds light on the link between gut microbiota, isoflavones, and geniposide hepatotoxicity

A recent study published in Engineering has shed light on the relationship between gut microbiota, isoflavones, and geniposide hepatotoxicity.

26 May 2025

Machine learning tool identifies metabolic clues in colorectal cancer

Scientists aiming to advance cancer diagnostics have developed a machine learning tool that is able to identify metabolism-related molecular profile differences between patients with colorectal cancer and healthy people.

22 May 2025

Metabolite profiles in spinal fluid predict mortality in tuberculous meningitis

Radboudumc researchers Kirsten van Abeelen, Edwin Ardiansyah, Sofiati Dian, Vinod Kumar, Reinout van Crevel and Arjan van Laarhoven used metabolomics to study cerebrospinal fluid (CSF) samples from tuberculous meningitis patients in Vietnam and Indonesia, with long-standing collaborators from Bandung and Jakarta (Indonesia), the Broad Institute (Boston) and the Oxford University Research Unit in Ho Chi Minh City (Vietnam).

22 May 2025

Blood and urine tests reveal how much ultra-processed food you really eat, study finds

Researchers developed and validated blood and urine metabolite scores that objectively measure ultra-processed food (UPF) intake in adults. These biomarker profiles accurately distinguished between high- and low-UPF diets and may transform nutrition research and public health monitoring.

21 May 2025

NIH researchers develop poly-metabolite score to measure ultra-processed food intake

For the first time, researchers at the National Institutes of Health (NIH) identified patterns of metabolites in blood and urine that can be used as an objective measure of an individual's consumption of energy from ultra-processed foods.

20 May 2025

Newly discovered Cat1 protein halts viral infections by depleting cellular fuel

Every living creature on Earth needs to protect itself from things that would do it harm. Bacteria are no different. And despite their relative simplicity, they deploy remarkably savvy defensive strategies against viral invaders.

18 May 2025

Lipid overload in ascites weakens immune response in ovarian cancer

A Ludwig Cancer Research study has identified a key mechanism by which advanced ovarian cancers suppress anti-tumor immune responses and resist immunotherapies.

13 May 2025

Study identifies key enzyme linked to metastasis in head and neck cancer

A recent study published in Engineering has shed new light on the mechanisms underlying the metastasis of head and neck squamous cell carcinoma (HNSCC).

8 May 2025

How urine caffeine levels may help detect diabetic eye damage early

Researchers found that higher urinary levels of caffeine and specific metabolites, especially in men, were significantly associated with diabetic retinopathy risk. The cross-sectional study used NHANES 2009–2014 data and highlights potential biomarkers for early detection in diabetic populations.

7 May 2025

Ultra-processed foods increase risk of anxiety and depression, study shows

A large UK Biobank study linked ultra-processed food (UPF) consumption to increased risks of anxiety, depression, substance use disorder, and other mental health outcomes. A metabolomic signature associated with UPF intake partially mediated these relationships, especially in adults under 60.

5 May 2025

TM6SF2 gut-specific knockout aggravates liver lipid accumulation in MASLD mice

Metabolic dysfunction-associated steatotic liver disease (MASLD), is the most common form of chronic liver disease worldwide. This study aimed to explore the role of TM6SF2 in high-fat diet (HFD)-induced MASLD through the gut-liver axis.

5 May 2025

Phthalates in plastics linked to over 350,000 heart deaths worldwide

A global modeling study in eBioMedicine links phthalate exposure from plastics, especially DEHP metabolites, to over 356,000 cardiovascular deaths in 2018. Exposure was highest in Asia, the Middle East, and Africa, disproportionately affecting lower-income countries.

4 May 2025

Gut bacteria and metabolites reveal depression-linked patterns in older adults

A cross-sectional study of 400 older adults with metabolic syndrome reveals that individuals with depression have distinct gut microbiota and metabolite profiles. Eight bacterial genera and 15 fecal metabolites were significantly associated with depression, suggesting a gut-brain axis link.

29 Apr 2025

Obesity changes how the gut responds to plant compounds, researchers report

Researchers found that the impact of polyphenols rutin and genistein on the human fecal metabolome varies significantly by body mass index (BMI). Lower BMI individuals showed more diverse metabolic responses, revealing how gut health and obesity could shape polyphenol metabolism.

28 Apr 2025

Monoclonal antibody can effectively reverse bleeding complications linked to ticagrelor

An investigational monoclonal antibody called bentracimab can safely and effectively reverse potentially catastrophic bleeding complications linked to ticagrelor, a common drug used to treat patients with acute coronary syndromes, prior heart attack, stroke, and coronary artery disease.

24 Apr 2025

Scientists uncover surprising new link between gut health and blood cancer risk

Scientists at Cincinnati Children's along with an international team of researchers have discovered a surprising new connection between gut health and blood cancer risk-one that could transform how we think about aging, inflammation, and the early stages of leukemia.

23 Apr 2025