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Study reveals pathological mechanisms of synaptic dysfunction in patients with Huntington's disease

Huntington's disease (HD) is a hereditary brain disease caused by a mutation in the huntingtin gene. HD is a neurodegenerative disease without a cure that, after the onset of the disease at around 40 years of age, causes changes in personality and symptoms of dementia along with uncontrollable convulsive movements, ultimately leading to death.

19 Sep 2022

Mechanical forces generated by T cells influence the destruction of cancer cells

As a part of our immune defenses, cytotoxic T cells – or killer T cells – seek out and destroy cells that are infected or cancerous. This process is essential for the body's defense against diseases.

15 Sep 2022

New kind of synapse discovered in neurons’ tiny hairs

Scientists at HHMI's Janelia Research Campus have discovered a new kind of synapse in the tiny hairs on the surface of neurons.

1 Sep 2022

Alzheimer's disease disrupts visual memory by degrading cross-hemispheric cells

A new MIT study finds that Alzheimer's disease disrupts at least one form of visual memory by degrading a newly identified circuit that connects the vision processing centers of each brain hemisphere.

19 Aug 2022

Novel fusion protein drug for Alzheimer’s disease circumvents the neurotoxic inflammatory side effects

Although Aduhelm, a monoclonal antibody targeting amyloid beta (Aβ), recently became the first US FDA approved drug for Alzheimer's disease (AD) based on its ability to decrease Aβ plaque burden in AD patients, its effect on cognitive improvement is still controversial.

4 Aug 2022

IU researchers evaluate the efficacy of a failed clinical trial drug for Alzheimer's using rigorous pipeline

Most drugs developed to treat Alzheimer's disease have for years been ineffective in clinical trials. Researchers from Indiana University School of Medicine recently evaluated the efficacy of a failed clinical trial drug using their rigorous pipeline.

25 Jul 2022

LMU cell biologists show how interactions between RNA-binding proteins affect synaptic plasticity in neurons

LMU scientists demonstrate that interactions between RNA-binding proteins affect translation and consequently the complexity of neurons.

4 Jul 2022

FUJIFILM Corporation Commit Themselves to Digital Pathology

FUJIFILM Corporation is at the forefront of the digital histopathology revolution, centered around the Dynamyx™ software by Inspirata, and supported by genuine partnerships that drive improvements in patient care.

From FUJIFILM Corporation 22 Jun 2022

Proteomic analysis of 2002 tumors reveals 11 distinct pan-cancer molecular subtypes

A new study that analyzed protein levels in 2,002 primary tumors from 14 tissue-based cancer types identified 11 distinct molecular subtypes, providing systematic knowledge that greatly expands a searchable online database that has become a go-to platform for cancer data analysis by users worldwide.

10 Jun 2022

Research suggests two protein coding genes can predict severe COVID-19

In a recent study posted to the medRxiv* pre-print server, researchers demonstrated that two genes, GTPase, IMAP Family Member 7 (GIMAP7), and sphingosine-1-phosphate receptor 2 (S1PR2), have the potential to predict severe coronavirus disease 2019 (COVID-19) with ~90% accuracy.

8 Jun 2022

Discovery of small protein’s structure could lead to new therapies for neurological disorders

Scientists have, for the first time, revealed at the atomic level the structure of a protein that carries one of the body's most important neurotransmitters into neurons.

8 Jun 2022

Age exacerbates COVID neuroimmunological symptoms

In a recent study posted to the bioRxiv* pre-print server, researchers at the University of Illinois at Chicago investigated whether aging exacerbated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-induced neuropsychiatric disorders.

6 Jun 2022

Molecular 'connector' may underlie gender differences in cocaine’s effects, mice study shows

Scientists have long known that cocaine works by latching on to molecular connectors on the surface of brain cells, allowing dopamine, a chemical that promotes feelings of pleasure and reward, to accumulate in the space between brain cells.

3 Jun 2022

Researchers discover mechanisms underlying T-cell receptor's immunosuppressive function

Investigators have discovered the mechanisms underlying a T-cell receptor's immunosuppressive function, according to a study published Nature Immunology, findings that may provide insight into the development of novel precision therapeutics for chronic diseases, including cancer.

25 May 2022

Antibiotic rifampicin attenuates C9orf72-linked dementia in genetically modified mice

What did Stephen Hawking and Mao Zedong have in common? They both suffered from Amyotrophic Lateral Sclerosis (ALS), a cure for which remains elusive. Scientists from Osaka Metropolitan University took an important step toward prevention of ALS and another brain disorder called Frontotemporal dementia (FTD) with their research on the effects of the antibiotic rifampicin on genetically modified mice.

23 May 2022

A nano-sized neuromorphic memory device simultaneously emulates neurons and synapses

Researchers have reported a nano-sized neuromorphic memory device that emulates neurons and synapses simultaneously in a unit cell, another step toward completing the goal of neuromorphic computing designed to rigorously mimic the human brain with semiconductor devices.

20 May 2022

Synapse News and Research

Study reveals pathological mechanisms of synaptic dysfunction in patients with Huntington's disease

Mechanical forces generated by T cells influence the destruction of cancer cells

New kind of synapse discovered in neurons’ tiny hairs

Alzheimer's disease disrupts visual memory by degrading cross-hemispheric cells

Novel fusion protein drug for Alzheimer’s disease circumvents the neurotoxic inflammatory side effects

IU researchers evaluate the efficacy of a failed clinical trial drug for Alzheimer's using rigorous pipeline

LMU cell biologists show how interactions between RNA-binding proteins affect synaptic plasticity in neurons

FUJIFILM Corporation Commit Themselves to Digital Pathology

Proteomic analysis of 2002 tumors reveals 11 distinct pan-cancer molecular subtypes

Research suggests two protein coding genes can predict severe COVID-19

Discovery of small protein’s structure could lead to new therapies for neurological disorders

Age exacerbates COVID neuroimmunological symptoms

Molecular 'connector' may underlie gender differences in cocaine’s effects, mice study shows

Researchers discover mechanisms underlying T-cell receptor's immunosuppressive function

Antibiotic rifampicin attenuates C9orf72-linked dementia in genetically modified mice

A nano-sized neuromorphic memory device simultaneously emulates neurons and synapses

Researchers discover how one type of T cell creates functionally distinct, but genetically identical daughter cells

Repeated DNA sequences in the genome may contribute to schizophrenia risk

Changes in gut microbiome impact depression

Impact of COVID-19 during pregnancy on development of fetal auditory system

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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