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Unlocking the power of mRNA vaccines: From COVID-19 to cancer and beyond

A comprehensive review in Signal Transduction and Targeted Therapy delves into the versatility and effectiveness of mRNA vaccines, from their game-changing role in COVID-19 to potential applications in cancer and rare diseases. Despite drawbacks like stability and high immunogenicity, advancements in vaccine technology have poised mRNA platforms as a robust tool for both preventive and therapeutic interventions.

21 Sep 2023

Digital vision training may not be an effective treatment for amblyopia in children

In the "ThemenCheck Medizin" procedure offered by the German Institute for Quality and Efficiency in Health Care (IQWiG), interested members of the public can submit proposals for the assessment of medical procedures and technologies.

21 Sep 2023

Scientists develop Australia’s first-of-its-kind next-gen mpox diagnostic tool

In a collaborative study published in The Lancet Microbe, the team of scientists, led by the Peter Doherty Institute for Infection and Immunity (Doherty Institute) and WEHI (Walter and Eliza Hall Institute of Medical Research), revealed MPXV-CRISPR – a powerful diagnostic tool capable of detecting MPXV in clinical samples with acute precision and at a faster rate than any other method, thanks to the power of CRISPR technology.

20 Sep 2023

CST and Leica Biosystems partner to enable companion diagnostics for personalized medicine

Cell Signaling Technology (CST), a life science discovery technology company and leading provider of antibodies, kits, and services, is partnered with Leica Biosystems, a technology leader in automated staining and brightfield and fluorescent imaging, to support the development of companion diagnostics (CDx) assays using the extensive portfolio of best-in-class antibodies from CST validated for immunohistochemistry (IHC).

From Cell Signaling Technology 20 Sep 2023

Hospital wastewater teeming with antibiotic-resistant genes, poses infection risk

Researchers from the UK and the Republic of Ireland have found high levels of antibiotic-resistant genes in the wastewater system of a major teaching hospital. The findings underscore the urgent need for regular decontamination and more stringent infection control measures to protect patients.

19 Sep 2023

UK Markey Cancer Center becomes NCI-Designated Comprehensive Cancer Center

The University of Kentucky Markey Cancer Center announced today that it has earned a National Cancer Institute "Comprehensive" Cancer Center designation, the highest level of recognition awarded by the NCI. Markey is the first and only center in Kentucky to achieve this designation, and the next-closest Comprehensive Cancer Center is nearly 200 miles from Lexington.

15 Sep 2023

New nano-thin superbug-slaying material could revolutionize wound healing

Researchers have invented a nano-thin superbug-slaying material that could one day be integrated into wound dressings and implants to prevent or heal bacterial infections.

14 Sep 2023

A novel multi-epitope vaccine targeting extracellular proteins of Chlamydia pneumoniae

Researchers designed and evaluated a multi-epitope vaccine targeting the main outer membrane protein of Chlamydia pneumoniae using immunoinformatics.

14 Sep 2023

UC Riverside study uncovers COVID's Achilles heel

New UC Riverside research has revealed COVID's Achilles heel -; its dependence on key human proteins for its replication -; which can be used to prevent the virus from making people sick.

13 Sep 2023

Unlocking the secret drivers of deadly pancreatic cancer: New target offers hope for treatment

Researchers identify a super-enhancer-regulated RNA-binding protein cascade that drives the growth of pancreatic ductal adenocarcinoma, a deadly form of pancreatic cancer. The discovery offers a promising new avenue for targeted therapy, potentially sidestepping severe side effects associated with other treatments.

10 Sep 2023

Study reports an increase in incidence of islet autoimmunity after SARS-CoV-2 infection in young children

Type 1 diabetes is an autoimmune disease leading to an impaired glucose metabolism and requires life-long administration of insulin.

8 Sep 2023

Zebrafish study unravels how the brain orchestrates motion

The zebrafish brain, though simpler than its human counterpart, is a complex network of neurons that engage in a ceaseless dance of electrical activity.

8 Sep 2023

New way to administer CAR-T-cell therapy could lead to fewer side effects

When Richard O'Neil, Ph.D., joined MUSC Hollings Cancer Center two years ago, he knew that he wanted to continue finding ways to make CAR-T-cell therapy easier on patients.

8 Sep 2023

Blood clots may be a cause of long-term cognitive problems after COVID-19

High levels of two proteins at the time of COVID-19 have been found in patients who later experienced cognitive problems, including 'brain fog', giving a major clue as to one cause of their symptoms: blood clots.

7 Sep 2023

Review identifies future research directions for the study of a SARS-CoV-2 reservoir in PASC

Researchers reviewed the evidence for SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC).

6 Sep 2023

Could a new framework for aging biomarkers revolutionize how we understand and treat the aging process?

A comprehensive review in the journal Cell outlines a unified framework for classifying and validating aging biomarkers, aiming to streamline their integration into clinical research and practice. The study categorizes biomarkers into types like molecular, functional, and clinical, and sets criteria for their feasibility, validity, and applicability, all with the goal of better understanding and intervening in the aging process.

5 Sep 2023

New tool can diagnose autism in children as young as 16 months

Results of clinical studies published simultaneously today in the Journal of the American Medical Association (JAMA) and in JAMA Network Open demonstrate that measuring children's looking behavior predicts expert clinical diagnosis of autism in children between ages 16 to 30 months tested with a high degree of accuracy.

5 Sep 2023

New study highlights impact of COVID-19 pandemic on emergency department visits in British Columbia

A new study showing the impact of the COVID-19 pandemic and mitigation strategies used to manage the virus on emergency department (ED) visits in British Columbia can help with future planning.

5 Sep 2023

Study explores the role of sex on mRNA and protein levels and its genetic regulation in brain

Researchers investigated the impact of biological sex on protein levels and its genomic control by analyzing 1,277 proteomes of the brain.

4 Sep 2023

Amgen presents late-breaking Phase 2 olpasiran data at ESC 2023

Amgen today announced data from the final analysis of the Phase 2 OCEAN(a)-DOSE study of olpasiran, a small interfering RNA (siRNA) during the Late-Breaking Science Session at the European Society of Cardiology (ESC) Annual Meeting being held in Amsterdam. In the off-treatment extension period, olpasiran showed a lasting effect on Lp(a) reduction nearly a year after the last dose.

From AMGEN 1 Sep 2023

Translation News and Research

Unlocking the power of mRNA vaccines: From COVID-19 to cancer and beyond

Digital vision training may not be an effective treatment for amblyopia in children

Scientists develop Australia’s first-of-its-kind next-gen mpox diagnostic tool

CST and Leica Biosystems partner to enable companion diagnostics for personalized medicine

Hospital wastewater teeming with antibiotic-resistant genes, poses infection risk

UK Markey Cancer Center becomes NCI-Designated Comprehensive Cancer Center

New nano-thin superbug-slaying material could revolutionize wound healing

A novel multi-epitope vaccine targeting extracellular proteins of Chlamydia pneumoniae

UC Riverside study uncovers COVID's Achilles heel

Unlocking the secret drivers of deadly pancreatic cancer: New target offers hope for treatment

Study reports an increase in incidence of islet autoimmunity after SARS-CoV-2 infection in young children

Zebrafish study unravels how the brain orchestrates motion

New way to administer CAR-T-cell therapy could lead to fewer side effects

Blood clots may be a cause of long-term cognitive problems after COVID-19

Review identifies future research directions for the study of a SARS-CoV-2 reservoir in PASC

Could a new framework for aging biomarkers revolutionize how we understand and treat the aging process?

New tool can diagnose autism in children as young as 16 months

New study highlights impact of COVID-19 pandemic on emergency department visits in British Columbia

Study explores the role of sex on mRNA and protein levels and its genetic regulation in brain

Amgen presents late-breaking Phase 2 olpasiran data at ESC 2023

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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