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APOLLO AI learns from 25 billion medical events to predict future disease

APOLLO is a multimodal temporal foundation model trained on 25.2 billion medical events from 7.2 million patients across 33 years of Mass General Brigham records, integrating 28 medical modalities into unified “virtual patient representations.” Across 322 downstream tasks, the model showed strong performance in disease prediction, treatment-response stratification, hospital operations, and patient retrieval, supporting the idea of more computable, data-driven medicine.

23 Apr 2026

Endoscopic procedure may prevent weight regain after GLP-1 discontinuation

An outpatient procedure may offer a way for the estimated 70% of people who discontinue popular weight-loss drugs to avoid regaining the pounds they shed, according to a study to be presented at Digestive Disease Week (DDW) 2026.

23 Apr 2026

Vitamin D may prevent diabetes in people with certain genes

More than two in five U.S. adults has prediabetes, a condition marked by higher-than-normal blood sugar levels that often leads to type 2 diabetes.

23 Apr 2026

Google search trends reflect a shift toward minimally invasive heart care

New research found that public interest in Transcatheter Aortic Valve Replacement (TAVR) increased substantially over the last decade, with Google search volume rising by 340% from 2015 to 2025, while searches for SAVR (Surgical Aortic Valve Replacement) declined by 42%.

23 Apr 2026

Rectal cancer deaths in older millennials are rising rapidly

Rectal cancer deaths among older millennials are accelerating, with growth in mortality far outpacing colon cancer, suggesting primary care doctors should fully investigate early symptoms in patients under age 45, according to a study to be presented at Digestive Disease Week (DDW) 2026.

23 Apr 2026

Tirzepatide significantly reduces cardiovascular risk in high-risk patients

Two new studies show that tirzepatide, a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist (RA), significantly reduces cardiovascular risk in high-risk patients, including those undergoing percutaneous coronary intervention (PCI) and those with obesity undergoing transcatheter aortic valve replacement (TAVR).

23 Apr 2026

Researchers receive NIH grant to accelerate Alzheimer's drug discovery efforts

Dr. Damian Young, investigator at Texas Children's Duncan Neurological Research Institute (Duncan NRI) and director of the Center for Drug Discovery at Baylor College of Medicine, along with collaborators has been awarded a $6.7 million grant from the National Institute on Aging (NIA), part of the National Institutes of Health (NIH), to develop new approaches to rapidly identify potential treatments for Alzheimer's disease and related dementias with the goal of accelerating the discovery of new therapies.

23 Apr 2026

High levels of gut bacterial toxin linked to increased lupus nephritis risk

The body's immune reaction to increased levels of a toxic molecule, part of a bacterial species in the human gut, may reveal who is most at risk of developing lupus nephritis, according to a new study led by NYU Langone Health.

23 Apr 2026

Late-night eating may amplify the effects of stress on gut health

It's well known that chronic stress can disrupt bowel function, sending people running to the bathroom or making them constipated.

23 Apr 2026

Restoring gut microbiome may prevent liver cancer in mice

Restoring the gut microbiome to its youthful state may hold the key to slowing aging and preventing liver cancer, one of the fastest-growing cancers worldwide, according to a study to be presented at Digestive Disease Week (DDW) 2026.

23 Apr 2026

Legume and soy consumption may improve COPD symptoms

Consuming legumes and soy-based foods may help improve symptoms of chronic obstructive pulmonary disease (COPD) by reducing inflammation and irritation, according to a new study in the March 2026 issue of Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation, a peer-reviewed, open access journal.

23 Apr 2026

Severe strokes significantly increase the risk of progressive dementia

As stroke severity increases, the risk of progressive cognitive decline and dementia substantially escalates, according to a national study led by Michigan Medicine researchers.

23 Apr 2026

USC and Tempus AI partner to advance precision medicine

The Keck School of Medicine of USC and Keck Medicine of USC have launched collaborations with Tempus AI, Inc., a technology company at the forefront of applying AI to precision medicine, to integrate clinical care, clinical trials and research through a unified framework.

23 Apr 2026

Metabolic health may shape future dementia risk for Latino communities

Researchers from the University of California San Diego have found that diabetes is linked to changes in measurable biological signals in the blood that are associated with Alzheimer's disease and brain damage in Latino adults.

23 Apr 2026

Study maps the evolution of myeloid leukemia in children with Down syndrome

It may be possible to identify which pre-cancerous cells will develop into a rare type of blood cancer, due to new research showing that a single genetic change drives myeloid leukemia in children with Down syndrome.

23 Apr 2026

New study maps early molecular changes in jaw joint osteoarthritis

Temporomandibular joint disorders (TMDs) affect a large portion of the global population and are a common source of chronic jaw pain and difficulty in chewing or speaking.

23 Apr 2026

Innovative light probes allow real-time visualization of cellular processes

Fluorescent proteins have revolutionized science, enabling researchers to tag and visualize individual molecules in living cells, tissues, and animals.

23 Apr 2026

Astrocytes form complex networks across the mouse brain

Cells long thought to play a secondary role in brain function build their own far-reaching connections, a new study in mice showed. These pathways appear to connect distant regions in ways that have not been mapped before.

23 Apr 2026

Bioengineered chewing gum reduces cancer-linked oral microbes

Researchers led by Henry Daniell of the School of Dental Medicine have shown that extracts from bioengineered chewing gum reduce the levels of three microbes known to be associated with head and neck squamous cell cancer (HNSCC), paving the way for more effective and affordable therapies.

23 Apr 2026

New gene therapy improves hearing in patients with rare genetic deafness

A new international study co-led by investigators from Mass General Brigham and the Eye & ENT Hospital of Fudan University shows that a gene therapy for a rare form of genetic deafness successfully restored hearing in most participants, with results lasting up to 2.5 years.

23 Apr 2026