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NIH grant renewal will enable Nebraska scientist to advance research on virtual immune system

The renewal of a National Institutes of Health grant will enable a University of Nebraska-Lincoln researcher to continue developing a tool that illuminates the complex, multi-scale interplay of the immune system's many components.

8 Feb 2022

Impact of SARS-CoV-2 Omicron and Delta variants on serious hospital events

In a new study, a team of researchers assessed the differences in risk of hospitalization in adults after infection with SARS-CoV-2 Omicron and Delta variants.

8 Feb 2022

Research reveals a possible strategy to prevent B-cell acute lymphoblastic leukemia

Short-term treatment with the drug ruxolitinib prevents B-cell acute lymphoblastic leukemia (B-ALL) in mice that have a genetic predisposition to the disease.

8 Feb 2022

Omicron sequences containing Delta mutation detected during SARS-CoV-2 genomic surveillance

This research letter published in Emerging Infectious Diseases warns scientists to interpret unusual mutations with caution.

7 Feb 2022

Evolutionary history of ACE2 binding across a diverse range of sarbecoviruses and ACE2 orthologs

Researchers have been investigating sarbecovirus lineages and the ability of those lineages to evolve the ability to bind ACE2.

7 Feb 2022

A novel approach to predict mutations within the SARS-CoV-2 spike

A study posted recently to the bioRxiv* preprint server demonstrated that the emergence of new spike variants of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can be predicted.

6 Feb 2022

Predicting immunity evasion of SARS-CoV-2 Omicron variant of concern

In a new study, a team of researchers assessed the affinity of the SARS-CoV-2 Omicron variant of concern towards major histocompatibility complex (MHC) binding

4 Feb 2022

Molecular simulations provide insight into SARS-CoV-2 variant RBD interactions with ACE2 and mAbs

Researchers aimed to understand the relationship between the SARS-CoV-2 receptor-binding domain and both human receptors and therapeutic targets.

3 Feb 2022

Evaluating effects of D614G and P681R/H mutations on SARS-CoV-2 VOCs

Researchers evaluate how the D614G and P681H mutations alter the attributes of SARS-CoV-2 VOCs.

3 Feb 2022

Roswell Park scientists identify a potential new treatment target for pancreatic cancer

Scientists at Roswell Park Comprehensive Cancer Center have identified a potential new target for the treatment of pancreatic cancer.

3 Feb 2022

Study identifies a genetic mutation linked to high risk of lethal childhood leukemia

A genetic variant changing just one base pair of nucleotides greatly increases risk of a high-risk subtype of childhood acute lymphoblastic leukemia (ALL), according to a Northwestern Medicine study published in Nature Genetics.

3 Feb 2022

Antigenic map of SARS-CoV-2 variants reveals amino acid substitutions that govern immune escape and immunodominance

Researchers use antigenic cartography to analyze cross-reactivity patterns of eight groups of human sera on a panel of SARS-CoV-2 variants.

2 Feb 2022

Three different autism risk genes found to have similar effects on brain development

Autism spectrum disorder has been associated with hundreds of different genes, but how these distinct genetic mutations converge on a similar pathology in patients has remained a mystery.

2 Feb 2022

UCLA researchers develop first human genomic transgenic mouse model of Huntington's disease

Researchers at the Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA and the David Geffen School of Medicine at UCLA have developed a new mouse model of Huntington's disease that recapitulates more Huntington's disease-like characteristics than earlier models.

2 Feb 2022

Non-mutated ApoE protein linked to dementia

A team of researchers from the University of Kentucky's Sanders-Brown Center on Aging is working to identify new proteins that are destructive to the brain.

2 Feb 2022

N gene target failure method effectively detects SARS-CoV-2 Omicron in clinical samples

In a new study, researchers demonstrated that a commercial real-time polymerase chain reaction (RT-PCR) assay rapidly detects the SARS-CoV-2 Omicron variant.

2 Feb 2022

Representative structures of SARS-CoV-2 and development of therapeutic agents for targeting these proteins

Researchers from China summarized the representative structures of SARS-CoV-2 proteins and discussed the development of novel therapeutic agents for targeting these proteins to treat and prevent COVID-19.

2 Feb 2022

Scientists develop platform to track SARS-CoV-2 lineages

A team of researchers led by Laura D. Hughes from The Scripps Research Institute in California created an online platform called Outbreak.info to track over 40 million lineages and SARS-CoV-2 mutation across 7,000 locations.

1 Feb 2022

Developing post-vaccination SARS-CoV-2 standard reference sera

A new study reports the generation of reference sera reagents that were obtained from subjects vaccinated with one of four COVID-19 vaccines.

1 Feb 2022

Families of Black patients found to have greater risk for dilated cardiomyopathy

Black patients diagnosed with dilated cardiomyopathy (DCM) of unknown cause are more likely to have family members at risk of developing the heart muscle disease than families of white patients, according to results of a multi-site study led by researchers at The Ohio State University Wexner Medical Center and College of Medicine.

1 Feb 2022

Mutation News and Research

NIH grant renewal will enable Nebraska scientist to advance research on virtual immune system

Impact of SARS-CoV-2 Omicron and Delta variants on serious hospital events

Research reveals a possible strategy to prevent B-cell acute lymphoblastic leukemia

Omicron sequences containing Delta mutation detected during SARS-CoV-2 genomic surveillance

Evolutionary history of ACE2 binding across a diverse range of sarbecoviruses and ACE2 orthologs

A novel approach to predict mutations within the SARS-CoV-2 spike

Predicting immunity evasion of SARS-CoV-2 Omicron variant of concern

Molecular simulations provide insight into SARS-CoV-2 variant RBD interactions with ACE2 and mAbs

Evaluating effects of D614G and P681R/H mutations on SARS-CoV-2 VOCs

Roswell Park scientists identify a potential new treatment target for pancreatic cancer

Study identifies a genetic mutation linked to high risk of lethal childhood leukemia

Antigenic map of SARS-CoV-2 variants reveals amino acid substitutions that govern immune escape and immunodominance

Three different autism risk genes found to have similar effects on brain development

UCLA researchers develop first human genomic transgenic mouse model of Huntington's disease

Non-mutated ApoE protein linked to dementia

N gene target failure method effectively detects SARS-CoV-2 Omicron in clinical samples

Representative structures of SARS-CoV-2 and development of therapeutic agents for targeting these proteins

Scientists develop platform to track SARS-CoV-2 lineages

Developing post-vaccination SARS-CoV-2 standard reference sera

Families of Black patients found to have greater risk for dilated cardiomyopathy

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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