Immune Response News and Research

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New approach leverages macrophages to treat traumatic brain injury

Scientists have created a new treatment for traumatic brain injury (TBI) that shrank brain lesions by 56% and significantly reduced local inflammation levels in pigs.

3 Jan 2024

Rare immune cell holds key to predicting melanoma treatment success

A type of immune cell can help predict which patients may benefit most from cancer immunotherapies, researchers from King's College London, Guy's and St Thomas' Hospital Trust, and the Francis Crick Institute have found.

3 Jan 2024

Are pan-coronavirus vaccines an achievable goal in providing broad protection against human coronaviruses?

The current achievements in the development of a pan-coronavirus vaccine.

3 Jan 2024

Small molecule-switchable RNA platform enables control of therapeutic protein expression

Just like a doctor adjusts the dose of a medication to the patient's needs, the expression of therapeutic genes, those modified in a person to treat or cure a disease via gene therapy, also needs to be maintained within a therapeutic window.

2 Jan 2024

"NK cell-engaging nanodrones" can selectively target and kill cancer cells

A groundbreaking study led by Professor Sebyung Kang and Professor Sung Ho Park in the Department of Biological Sciences at UNIST has unveiled a remarkable breakthrough in cancer treatment.

29 Dec 2023

New non-steroidal anti-inflammatory can inhibit the cytokine storm and preserve innate immunity

Very early in the COVID-19 pandemic clinical trials in patients hospitalized with COVID-19 confirmed that corticosteroids like dexamethasone reduced mortality, but they were harmful when applied at the first COVID-19 symptoms, due to the weakening of innate antiviral immunity, leading to delayed viral clearance and adverse outcomes in severe viral pneumonias.

28 Dec 2023

New model links RNA editing glitch to early-stage type 1 diabetes

Hebrew University study proposes a new model suggesting that disrupted RNA editing within pancreatic beta cells might initiate an inflammatory response akin to early-stage type 1 diabetes.

26 Dec 2023

R21/Matrix-M vaccine gets WHO green light for global rollout

The R21/Matrix-M™ malaria vaccine is one step closer to mass rollout, after officially receiving WHO prequalification status, making it eligible for procurement by United Nations agencies.

21 Dec 2023

Inside the Pentagon’s painfully slow effort to clean up decades of PFAS contamination

Oscoda, Michigan, has the distinction as the first community where "forever chemicals" were found seeping from a military installation into the surrounding community.

21 Dec 2023

Protein "on/off switch" controls breast cancer spread and immunotherapy response

Despite their promise, immunotherapies fail to treat many cancers, including over 80% of some of the most advanced breast cancers.

20 Dec 2023

How a malaria drug may hold the key to ending malnutrition's cycle of devastation

Wars, drought, displacement, and instability are causing a dramatic increase in the number of pregnant and breastfeeding women around the world who suffer from malnutrition.

20 Dec 2023

New vaccine design targets universal immunity with "chef"-inspired tool

Vaccine development aims at protecting as many people as possible from infections. Short protein fragments of pathogens, so-called epitopes, are seen as a promising new approach for vaccine development.

20 Dec 2023

Embryonic immune sensor could key to creating patient-derived blood stem cells

A microbial sensor that helps identify and fight bacterial infections also plays a key role in the development of blood stem cells, valuable new insight in the effort to create patient-derived blood stem cells that could eliminate the need for bone marrow transplants.

19 Dec 2023

UCL scientists receive £997,000 from the Type 1 Diabetes Grand Challenge

Scientists at the UCL Institute of Immunity & Transplantation (IIT) are part of a team to receive £997,000 from the Type 1 Diabetes Grand Challenge, a new partnership involving The Steve Morgan Foundation, Diabetes UK and JDRF.

19 Dec 2023

New vaccine strategy targets SARS-CoV-2's stable S2 subunit, offering broad protection against evolving variants

Study presents a new SARS-CoV-2 S2 subunit vaccine that elicits strong antibody responses against various sarbecovirus strains, including challenging variants like XBB.1.5, demonstrating its potential as a broadly effective and stable vaccine option.

18 Dec 2023

Maternal microbiome's pivotal role in shaping fetal and neonatal immune systems during pregnancy

Review in Nature Reviews Gastroenterology and Hepatology explores how the maternal microbiome during pregnancy influences the immune systems of the mother, fetus, and neonate, highlighting its impact on long-term health outcomes and the development of pregnancy complications.

18 Dec 2023

Leaky gut linked to depressive disorders: New insights into microbiota-induced epigenetic changes

A study in the journal Genes highlights how a leaky gut can lead to depressive disorders through changes in gut microbiota-derived metabolites, emphasizing the role of diet, environmental factors, and probiotics in managing these conditions.

18 Dec 2023

Two proteins in the blood could predict dengue severity

Scientists and clinicians at Nanyang Technological University, Singapore (NTU Singapore) and the National Centre for Infectious Diseases (NCID) have identified two compounds - sST2 and suPAR - in the blood of dengue patients that could determine if a patient is at risk of severe dengue in the early phases of the disease.

18 Dec 2023

Wnt signaling holds promise for tailored immunotherapy in microsatellite-instable colorectal cancer

Colorectal cancer presents with varying clinical characteristics due to tumor heterogeneity. Microsatellite instability (MSI), present in 10%-15% of CRC cases, indicates a different clinical trajectory than microsatellite stable (MSS) patients.

15 Dec 2023

NIAID study identifies critical T-cell function missing in prior HIV vaccine candidates

An effective HIV vaccine may need to prompt strong responses from immune cells called CD8+ T cells to protect people from acquiring HIV, according to a new study from researchers at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and colleagues.

14 Dec 2023

Immune Response News and Research

New approach leverages macrophages to treat traumatic brain injury

Rare immune cell holds key to predicting melanoma treatment success

Are pan-coronavirus vaccines an achievable goal in providing broad protection against human coronaviruses?

Small molecule-switchable RNA platform enables control of therapeutic protein expression

"NK cell-engaging nanodrones" can selectively target and kill cancer cells

New non-steroidal anti-inflammatory can inhibit the cytokine storm and preserve innate immunity

New model links RNA editing glitch to early-stage type 1 diabetes

R21/Matrix-M vaccine gets WHO green light for global rollout

Inside the Pentagon’s painfully slow effort to clean up decades of PFAS contamination

Protein "on/off switch" controls breast cancer spread and immunotherapy response

How a malaria drug may hold the key to ending malnutrition's cycle of devastation

New vaccine design targets universal immunity with "chef"-inspired tool

Embryonic immune sensor could key to creating patient-derived blood stem cells

UCL scientists receive £997,000 from the Type 1 Diabetes Grand Challenge

New vaccine strategy targets SARS-CoV-2's stable S2 subunit, offering broad protection against evolving variants

Maternal microbiome's pivotal role in shaping fetal and neonatal immune systems during pregnancy

Leaky gut linked to depressive disorders: New insights into microbiota-induced epigenetic changes

Two proteins in the blood could predict dengue severity

Wnt signaling holds promise for tailored immunotherapy in microsatellite-instable colorectal cancer

NIAID study identifies critical T-cell function missing in prior HIV vaccine candidates

Revolutionizing Life Science: An Interview with SCIEX on ASMS, the SCIEX 7500+ System, and AI-Driven Quantitation

From Discovery Biology to ELRIG Chair

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