Metabolites News and Research

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How the gut microbiome links obesity to colorectal cancer

The gut microbiome serves as both a biomarker and therapeutic target in diseases like obesity, metabolic syndrome, and colorectal cancer.

28 Nov 2025

Chronic drinking weakens the blood-brain barrier through the gut

Chronic alcohol consumption disrupts the blood-brain barrier, but Faecalibacterium prausnitzii shows promise in repairing this damage and improving cognition.

27 Nov 2025

Polyphenol-rich dietary patterns linked to lower cardiovascular disease risk

People who regularly consume polyphenol-rich foods and drinks, such as tea, coffee, berries, cocoa, nuts, whole grains and olive oil, may have better long-term heart health.

27 Nov 2025

Head trauma impairs brain waste clearance in professional fighters

The brain's waste-clearing system significantly declines in function with repeated head impacts, according to a new study of cognitively impaired professional boxers and mixed martial arts fighters. The findings will be presented next week at the annual meeting of the Radiological Society of North America.

26 Nov 2025

Polyamines restore gut regeneration in aging mice

With aging, the intestine gradually loses its ability to regenerate after damage. An international research team involving the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena and the University of Turin has now found that polyamines, small molecules produced naturally in the body, can play a decisive role in this process.

25 Nov 2025

Wiley adds additional data to its SmartSpectra, IR, Raman, and LC-MS libraries

Wiley expands its spectral database with over 9.5 million high-quality spectra, enhancing compound identification for researchers in various scientific fields.

From John Wiley and Sons - Scientific Publishers 24 Nov 2025

Study finds GLP-1 drugs improve strength and reverse aging biology in mice

Researchers showed that GLP-1 receptor agonism counteracts aging across multiple organs in mice, improving strength and reversing molecular aging signatures without meaningful effects on body weight. These benefits depended largely on hypothalamic GLP-1R signaling and closely mirrored the anti-aging patterns produced by rapamycin.

23 Nov 2025

Does coffee truly boost memory and focus or is it all hype?

Coffee’s bioactive compounds, especially caffeine, show potential cognitive, neuroprotective, and neuroplasticity benefits across animal and human studies. However, most findings are observational, mechanisms remain uncertain, and optimal intake is still unclear.

23 Nov 2025

Eating lean beef as part of MED diet could improve gut diversity

Incorporating lean beef into a Mediterranean diet reduces TMAO levels and improves gut health, highlighting the importance of dietary patterns for wellness.

21 Nov 2025

UK Biobank releases the world’s largest metabolomic dataset for disease research

UK Biobank has today [Thursday 20 November] released the final set of data on nearly 250 metabolites – the molecules in our blood produced by our bodies as we go about our lives – in half a million volunteers.

20 Nov 2025

Research reveals new insights into the biology of recurrent miscarriage

Researchers at the Victor Chang Cardiac Research Institute, University of Sydney, and the Royal Hospital for Women have uncovered important new insights into the biology of recurrent miscarriage - a devastating condition that affects up to one in fifty couples trying to conceive.

19 Nov 2025

Lean beef fits safely into a Mediterranean diet without raising heart disease risk

Eating moderate amounts of lean beef as part of a Mediterranean diet does not increase an emerging risk factor for cardiovascular disease, according to a new study by an interdisciplinary research team at Penn State.

19 Nov 2025

Gut microbes may fuel allergic rhinitis symptoms

The study identifies gut microbiome alterations in allergic rhinitis, suggesting a gut-nose axis that could inform new treatment approaches for this condition.

17 Nov 2025

Scientists discover hidden weakness in Lyme disease bacterium

For decades, Lyme disease has frustrated both physicians and patients alike. Caused by the corkscrew-shaped bacterium Borrelia burgdorferi, the infection, if left untreated, can linger for months, leading to fever, fatigue and painful inflammation.

13 Nov 2025

Study advances the possibility of age-based pancreatic cancer treatment

While some risk factors for cancer can be mitigated through lifestyle choices such as diet or exercise, aging is not one of them. In the case of pancreatic cancer, it also can limit treatment options if a patient is too frail to be safely treated with surgery or other alternatives.

10 Nov 2025

Do dietary supplements really improve muscle health in non-athletes?

Dietary supplements can support muscle health, but their effectiveness varies. This review explores their role in physical activity and age-related muscle loss.

10 Nov 2025

Drinking orange juice daily may fine-tune genes tied to cardiovascular wellness

Regular orange juice consumption reprograms immune-cell gene activity linked to blood pressure, lipid metabolism, and inflammation in healthy adults. The molecular effects differ by body weight, suggesting BMI-tailored benefits from this everyday beverage.

9 Nov 2025

Low-dose THC mitigates harmful side effects and inflammation caused by HIV treatment

Long-term, low doses of THC mitigate many harmful side effects and inflammation caused by HIV and antiretroviral therapy (ART), according to new research from Texas Biomedical Research Institute.

6 Nov 2025

How gut microbes shape sleep: New review reveals microbiome clues to insomnia and apnea

A new Brain Medicine review maps how gut microbes influence sleep disorders, from insomnia and sleep apnea to circadian disruption, via bile acids, neurotransmitters, and immune pathways. The findings highlight gut-driven targets for improving sleep quality through diet, probiotics, and microbiome modulation.

5 Nov 2025

Gut bacteria metabolize nitrogen compounds to prevent cancer-causing nitrosamines

Nitrogen metabolism of gut bacteria can provide health benefits. Specifically, gut microbes metabolize dietary nitrates and nitrites and prevent the formation of cancer-causing compounds called nitrosamines.

5 Nov 2025