Inflammation News and Research

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Granzyme K+ CD8+ T-cells identified as key drivers of recurrent airway inflammation

Researchers identify a pathogenic subset of CD8+ memory T-cells that promote airway tissue inflammation and recurrent respiratory diseases.

17 Jan 2025

Inflammasome proteins found to prevent cancer by regulating stem cells

A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity, according to a preclinical study by Weill Cornell Medicine investigators.

17 Jan 2025

Tofacitinib reduces SARS-CoV-2 infection risk in patients with PTPN2 deficiency

Researchers report the ability of tofacitinib to reduce infection risk with SARS-CoV-2 in individuals who are deficient in PTPN2.

17 Jan 2025

Unveiling the metabolic pathways of Fusobacterium nucleatum in OSCC

A recent study has made significant strides in uncovering how the oral microbiome, particularly the bacterium Fusobacterium nucleatum, plays a crucial role in the progression of oral squamous cell carcinoma (OSCC). By identifying key interactions between this common oral bacterium and host cells, the research has unveiled important metabolic pathways and mechanisms that may serve as potential therapeutic targets.

17 Jan 2025

Immune cells orchestrate glucagon production during fasting

When we think about the immune system, we usually associate it with fighting infections. However, a study published in Science by the Champalimaud Foundation reveals a surprising new role.

17 Jan 2025

Pioglitazone may help prevent painful skin ulcers in people with Werner syndrome

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 22 on December 2, 2024, entitled "Less frequent skin ulcers among patients with Werner syndrome treated with pioglitazone: findings from the Japanese Werner Syndrome Registry."

16 Jan 2025

Wearable devices can identify and predict flare-ups in inflammatory bowel disease

Wearable devices can identify, differentiate, and predict flare-ups, or the worsening of symptoms and inflammation, in inflammatory bowel disease (IBD), Mount Sinai researchers have shown in a first-of-its-kind study.

16 Jan 2025

Study reveals dangerous mutations in H5N1 bird flu

One of the earliest strains of bird flu isolated from a human in Texas shows a unique constellation of mutations that enable it to more easily replicate in human cells and cause more severe disease in mice compared to a strain found in dairy cattle, researchers from Texas Biomedical Research Institute (Texas Biomed) report in Emerging Microbes & Infections.

16 Jan 2025

Drug in breast cancer trials shows potential for treating blood cancers

Two new studies led by researchers at Washington University School of Medicine in St. Louis have identified a possible way to block the progression of several forms of blood cancer using a drug already in clinical trials against breast cancer.

16 Jan 2025

Could mulberry extract be the key to fighting obesity-induced reproductive dysfunction?

Research indicates mulberry extract's efficacy in addressing obesity-related male infertility, enhancing reproductive outcomes through bioactive compounds.

16 Jan 2025

Targeting tertiary lymphoid structures for cancer treatment

A research team at Memorial Sloan Kettering Cancer Center (MSK) has made new insights into how the body forms immune cell clusters called tertiary lymphoid structures (TLSs) in response to foreign threats such as cancer.

16 Jan 2025

Antihistamine shows promise for treating rare genetic liver disease

A common antihistamine may offer hope for patients with a rare genetic disease that can lead to severe liver damage and ultimately require transplantation, according to new research from Rutgers Health.

16 Jan 2025

Exercise offers hope in the Alzheimer's battle

Regular aerobic exercise could significantly reduce disease markers associated with Alzheimer's, new research led by scientists at the University of Bristol (UK) and the Federal University of São Paulo (Brazil) has found. The findings provide new hope in the battle against this devastating disorder.

16 Jan 2025

McMaster researchers identify key immune cells linked to severe asthma

Researchers at McMaster University have made an important discovery in the field of asthma research, identifying a new population of immune cells that may play a crucial role in the severity of asthma symptoms.

15 Jan 2025

Hormonal shifts in menopause redefine women’s microbiome and risks

Research explores how menopause-induced hormonal shifts affect the microbiome, influencing oral, gut, and urogenital health, and highlights the potential of personalized interventions to enhance well-being.

15 Jan 2025

Study reveals how cigarette smoke weakens immune cells in the lungs

Cigarette smoking is widespread and deadly, yet our understanding of how cigarette smoke actually causes serious respiratory illnesses is incomplete, which has severely hampered the development of effective treatments.

15 Jan 2025

Researchers identify a natural defense against blood vessel inflammation and atherosclerosis

Research reveals IGFBP6's role in suppressing vascular inflammation and atherosclerosis, suggesting it as a novel target for cardiovascular disease therapy.

15 Jan 2025

The role of inflammation in the pathogenesis of heart failure

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Cardiovascular disease remains a leading cause of death and disability worldwide. Heart failure (HF) is the end stage of various cardiovascular diseases. Despite recent advancements in understanding of HF pathogenesis and treatment, the prognosis of patients with HF remains poor.

15 Jan 2025

Study unravels the links between obesity and cancer

Obesity, recognized as a complex and growing health issue, is associated with an increased risk of various cancers. A comprehensive review provides insights into the mechanisms linking obesity to cancer risk and discusses potential clinical implications.

15 Jan 2025

No short-term benefit found for PCT-guided antibiotic treatment in children

A groundbreaking UK study in The Lancet has examined whether an additional blood test called procalcitonin (PCT) could safely shorten the time children spend on intravenous (IV) antibiotics in hospitals.

15 Jan 2025