Cardiometabolic News and Research

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Ultra-processed foods linked to rise in prediabetes risk

The study reveals that ultra-processed foods heighten prediabetes risk in young adults with obesity history, stressing the importance of healthy eating habits.

25 Nov 2025

Oral GLP-1 pill shows strong weight loss and blood sugar benefits in adults with diabetes

A new oral GLP-1 medication can help adults with obesity and Type 2 diabetes lose more weight and improve their blood sugar levels compared to a placebo, according to findings from the ATTAIN-2 trial led by a UTHealth Houston researcher.

20 Nov 2025

Midlife exercise cuts dementia risk by up to 45 percent, new study shows

Higher physical activity in midlife and late life is linked to a substantially lower risk of all-cause and Alzheimer’s dementia. Midlife benefits are strongest for moderate or heavy activity, while late-life activity is protective across all intensity levels.

20 Nov 2025

Study develops highly accurate polygenic risk models tailored for Han Chinese populations

Researchers at Academia Sinica have developed the first population-specific polygenic risk score (PRS) models for people of Han Chinese ancestry, achieving unprecedented accuracy in predicting risks for common diseases such as diabetes, heart disease, autoimmune disorders.

20 Nov 2025

Study shows how ketogenic eating improves hormonal balance in PCOS

The very low-carbohydrate ketogenic diet leads to meaningful reductions in weight, visceral adiposity, insulin resistance, and androgen excess in women with PCOS based on pooled randomized trials. Benefits appear consistent across studies, though high heterogeneity, short durations, and limited safety data highlight the need for longer-term comparative research.

19 Nov 2025

Lean beef fits safely into a Mediterranean diet without raising heart disease risk

Eating moderate amounts of lean beef as part of a Mediterranean diet does not increase an emerging risk factor for cardiovascular disease, according to a new study by an interdisciplinary research team at Penn State.

19 Nov 2025

BMI is failing to detect dangerous obesity as people age

A landmark study finds waist-to-height ratio more effective than BMI in identifying obesity risk, as central fat levels rise across the UK population.

19 Nov 2025

Study links obesity severity to escalating cardiometabolic and renal disease burden

Obesity severity is incrementally associated with a broad range of cardiometabolic and renal disease burden, as discovered by researchers at Pennington Biomedical Research Center. Recently published in Obesity, the paper "Association of Obesity Severity with Cardiometabolic and Renal Disease Burden in the United States," explored the relationship through a cross-sectional study of data from the U.S. Behavioral Risk Factor Surveillance System survey.

18 Nov 2025

Red meat raises inflammation marker CRP in clinical trials

The review analyzes red meat's effects on inflammatory biomarkers, revealing significant associations with CRP in specific adult subgroups and dietary contexts.

17 Nov 2025

Are mushrooms more than a low-calorie food? New analysis explains their hidden advantages

Whole mushroom consumption shows consistent benefits for cardiometabolic health, lowering triglycerides in self-chosen diets and improving fasting glucose in a single healthy dietary pattern trial. Early evidence also suggests increases in salivary IgA and possible blood pressure improvements, with no adverse biomarker effects reported.

16 Nov 2025

Dash diet cuts diabetes complications by targeting blood pressure kidney health and inflammation

The DASH diet supports metabolic health in people with diabetes by improving blood pressure, renal function, lipids, and modest glycemic markers while reducing risks linked to vascular and inflammatory pathways. Its broad nutrient-driven mechanisms also benefit related conditions such as neuropathy, PCOS, and retinopathy, making it a versatile tool for cardiometabolic care.

16 Nov 2025

WHO releases first global guidelines for managing diabetes during pregnancy

The World Health Organization (WHO) today released its first global guidelines for the management of diabetes during pregnancy, a condition affecting about one in six pregnancies – or 21 million women annually.

14 Nov 2025

Drinking orange juice daily may fine-tune genes tied to cardiovascular wellness

Regular orange juice consumption reprograms immune-cell gene activity linked to blood pressure, lipid metabolism, and inflammation in healthy adults. The molecular effects differ by body weight, suggesting BMI-tailored benefits from this everyday beverage.

9 Nov 2025

How diet affects aging metabolism differently for men and women

Research reveals sex-based differences in diet's impact on metabolism, highlighting plant proteins for men and moderate wine for women in older adults.

7 Nov 2025

How gut microbes shape sleep: New review reveals microbiome clues to insomnia and apnea

A new Brain Medicine review maps how gut microbes influence sleep disorders, from insomnia and sleep apnea to circadian disruption, via bile acids, neurotransmitters, and immune pathways. The findings highlight gut-driven targets for improving sleep quality through diet, probiotics, and microbiome modulation.

5 Nov 2025

Researchers uncover molecular key to prevent brown fat decline with age

As the body ages, brown adipose tissue activity decreases, fewer calories are burned, and this can contribute to obesity and certain chronic cardiovascular diseases that worsen with age.

5 Nov 2025

Swapping meat for plant-based options cuts fat but lowers protein, study finds

Replacing meat with plant-based or mycoprotein alternatives in UK diets lowers saturated fat and boosts fiber but reduces protein intake, especially for teens and older adults. The overall saturated fat reduction is too small to meaningfully affect cholesterol levels, researchers report in npj Science of Food.

4 Nov 2025

GLP-1 drugs calm inflammation beyond diabetes and weight loss

This Journal of Clinical Investigation review describes how glucagon-like peptide-1 (GLP-1)–based medicines reduce systemic and tissue inflammation through both weight-dependent and weight-independent mechanisms. It details preclinical and clinical evidence linking GLP-1 receptor activation to cardiovascular, renal, hepatic, neural, and joint anti-inflammatory effects while outlining uncertainties and future research needs.

4 Nov 2025

New review illuminates the intricate connections between gut microbiota and sleep regulation

A comprehensive review published today in Brain Medicine illuminates the intricate connections between gut microbiota and sleep regulation, establishing the microbiota-gut-brain axis as a critical pathway in understanding and potentially treating sleep disorders.

4 Nov 2025

Long-term use of melatonin supplements linked to higher risk of heart failure and death

Long-term use of melatonin supplements, often used to promote sleep and address insomnia, was associated with a higher risk of heart failure diagnosis, heart failure hospitalization and death from any cause in chronic insomnia, according to a preliminary study to be presented at the American Heart Association's Scientific Sessions 2025.

3 Nov 2025

Cardiometabolic News and Research

Ultra-processed foods linked to rise in prediabetes risk

Oral GLP-1 pill shows strong weight loss and blood sugar benefits in adults with diabetes

Midlife exercise cuts dementia risk by up to 45 percent, new study shows

Study develops highly accurate polygenic risk models tailored for Han Chinese populations

Study shows how ketogenic eating improves hormonal balance in PCOS

Lean beef fits safely into a Mediterranean diet without raising heart disease risk

BMI is failing to detect dangerous obesity as people age

Study links obesity severity to escalating cardiometabolic and renal disease burden

Red meat raises inflammation marker CRP in clinical trials

Are mushrooms more than a low-calorie food? New analysis explains their hidden advantages

Dash diet cuts diabetes complications by targeting blood pressure kidney health and inflammation

WHO releases first global guidelines for managing diabetes during pregnancy

Drinking orange juice daily may fine-tune genes tied to cardiovascular wellness

How diet affects aging metabolism differently for men and women

How gut microbes shape sleep: New review reveals microbiome clues to insomnia and apnea

Researchers uncover molecular key to prevent brown fat decline with age

Swapping meat for plant-based options cuts fat but lowers protein, study finds

GLP-1 drugs calm inflammation beyond diabetes and weight loss

New review illuminates the intricate connections between gut microbiota and sleep regulation

Long-term use of melatonin supplements linked to higher risk of heart failure and death

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