Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

Ketogenic diet leads in metabolic health improvements for diabetic patients

Study compares the effects of very-low-calorie ketogenic and Mediterranean diets on gut microbiota, metabolic health, and weight management in patients with newly diagnosed type 2 diabetes and obesity.

7 Jan 2025

Machine learning reveals how metabolite profiles predict aging and health

Researchers developed metabolomic aging clocks using machine learning, uncovering links between metabolite profiles, health outcomes, and lifespan.

1 Jan 2025

Lithocholic acid enhances health and lifespan, mimicking calorie restriction

Lithocholic acid (LCA), a metabolite induced by calorie restriction (CR), activates AMPK and mimics anti-aging benefits. A recent study highlights LCA's role in improving muscle performance, glucose tolerance, and lifespan in aged organisms.

1 Jan 2025

Advancing personalized nutrition through microbiome research

When making decisions about nutrition and diet, the focus is often on the potential impacts to the heart or brain; and gut health can frequently end up an afterthought despite a whole industry revolving around probiotics and digestive aids. With its direct link to those two important organs, should gut health be prioritized more?

23 Dec 2024

Breastfeeding after COVID-19 vaccination is safe, with minimal changes to milk composition

This study reveals how SARS-CoV-2 infection significantly alters human milk composition, while COVID-19 vaccination causes minimal, transient changes, underscoring the safety of breastfeeding during vaccination.

19 Dec 2024

AI-based aging clocks offer insights into health and lifespan

Researchers at the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London have conducted a comprehensive study to evaluate artificial intelligence based aging clocks, which predict health and lifespan using data from blood.

18 Dec 2024

New therapies and technologies provide hope for age-related fertility challenges

Scientists explore emerging strategies to combat reproductive aging, highlighting promising therapies and technologies to improve fertility in later life.

17 Dec 2024

LECO Instruments UK Ltd. announces a new training and research collaboration with the Liverpool Training Centre for Metabolomics

LECO Instruments UK Ltd., a subsidiary of USA-based LECO Corporation, is pleased to announce a new and exciting training and research collaboration with the Liverpool Training Centre for Metabolomics and Centre for Metabolomics Research at the University of Liverpool. These centers are internationally recognized for their expertise in the development of analytical chemistry and software tools and their metabolomic applications across the biological disciplines.

From LECO Corporation 17 Dec 2024

Unraveling the mystery of drug-induced liver injury

DILI is broadly categorized into intrinsic and idiosyncratic types. Intrinsic hepatotoxins, such as APAP, cause dose-dependent injury, while idiosyncratic DILI involves complex immune and metabolic interactions that remain poorly understood.

13 Dec 2024

Metabolomic biomarkers improve diabetes risk prediction accuracy

Researchers developed a novel diabetes risk score integrating traditional factors with metabolomic biomarkers, achieving improved prediction accuracy for 10-year type 2 diabetes risk.

12 Dec 2024

Mayo Clinic researchers advocate for comprehensive TPMT genotyping across ancestries

Mayo Clinic researchers found that a gene variant, the TPMT∗8 allele, is associated with reduced metabolism of the thiopurine class of drugs. TPMT∗8 is relatively common in individuals of African or African American descent. A novel study in The Journal of Molecular Diagnostics, published by Elsevier, details the researchers' goal to provide pharmacogenomic testing that can be used clinically to predict drug response that is beneficial to all patients, regardless of their ancestral background.

11 Dec 2024

Chemical footprints of breast cancer: A new exposomics approach

Researchers in Sweden explored chemical exposures in plasma samples and uncovered links between environmental factors and breast cancer risk influenced by age, parity, and menarche.

10 Dec 2024

Mouse study links glyphosate to Alzheimer's-like brain changes and anxiety

Glyphosate exposure in mice exacerbates Alzheimer's-like neuropathologies, increases neuroinflammation, and leaves lasting effects, even after prolonged recovery.

9 Dec 2024

Simple dietary supplement may provide new approach to boost CAR T cell cancer-fighting power

A simple dietary supplement may provide a new approach to boost CAR T cell function, according to a study from researchers in the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine's Abramson Cancer Center.

9 Dec 2024

Gut microbiome and brain evolution: New insights into energy allocation

Gut microbiota from primates with larger brains promotes glucose production and energy allocation for brain function, shedding light on metabolic strategies in evolution.

4 Dec 2024

Glyphosate exposure linked to lasting brain inflammation

The human brain is an incredibly adaptable organ, often able to heal itself even from significant trauma.

4 Dec 2024

MR1 molecule and vitamin B6 could unlock new paths for cancer immunotherapy

Effective immunity hinges on the ability to sense infection and cellular transformation. In humans, there is a specialized molecule on the surface of cells termed MR1.

27 Nov 2024

Placental defects linked to congenital heart defects

Congenital heart defects are the most common form of human birth defect, but we still don't fully understand what causes them.

26 Nov 2024

Fermented kimchi may help combat obesity by regulating gut microbiota

Kimchi consumption significantly reduces body fat and enhances metabolic indicators in overweight individuals, highlighting its role in obesity management.

22 Nov 2024

Researchers use cerebrospinal fluid to unlock pathways in Alzheimer's disease

A multitude of genes have been linked to the development of Alzheimer's disease. Specifically how those genes might influence the progression of neurodegeneration remains something of a black box though, in part because of the challenges of examining in molecular detail the brain of a living patient.

14 Nov 2024