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Using liver biopsies to identify predictors of pancreatic cancer metastasis

Researchers at Weill Cornell Medicine with an international team have used liver biopsies to identify cellular and molecular markers that can potentially be used to predict whether and when pancreatic cancer will spread to an individual's liver or elsewhere, such as the lung.

28 Jun 2024

AI identifies new high-risk subtype in endometrial cancer

An AI tool to classify histopathological images and differentiate between endometrial cancer subtypes.

28 Jun 2024

Antibody-drug conjugate effective, less toxic for stage 1 HER2+ breast cancer

A year of treatment with a medicine made of an antibody and chemotherapy drug has proven highly effective in preventing stage 1 HER2-positive breast cancer from recurring in patients, a team led by Dana-Farber Cancer Institute researchers has found.

28 Jun 2024

PFDN6 protein could be a new target for colorectal cancer treatment

Researchers have identified a protein called PFDN6 that may play a role in the development and spread of colorectal cancer (CRC).

27 Jun 2024

Rice and MD Anderson collaborative harnesses engineering expertise for cancer solutions

Led by Rice's Gang Bao and MD Anderson's Dr. Jeffrey Molldrem, the initiative aims to foster collaboration between the two institutions on fundamental and translational cancer research, to develop new technologies for cancer detection and therapy and to secure external funding in support of further research and training.

27 Jun 2024

Study identifies mechanism that impedes the effectiveness of melanoma therapies

In many cases of malignant melanoma, the effect of targeted treatment is lost over time. A research team from UZH and USZ has now discovered that a factor secreted by tumor cells is responsible for the resistance.

27 Jun 2024

$Assessing clinical benefit and safety in trial waivers for treatment-refractory cancers$

Assessing clinical benefit and safety in trial waivers for treatment-refractory cancers

Patients with treatment-refractory cancers who received eligibility and testing waivers to participate in a large basket/umbrella oncology trial had similar rates of clinical benefit and adverse events as patients who participated in the trial without waivers.

27 Jun 2024

Uptick in early-onset gastrointestinal cancers raises the need for better prevention and diagnosis

Treatment of gastrointestinal (GI) cancers is catching up with other areas of oncology and offering patients better prospects for survival and quality of life, but a significant uptick in early-onset cases is raising new questions about effective prevention, diagnosis and treatment.

27 Jun 2024

Fighting cancer with nanoparticles

Nanoparticles may be the future of the fight against pancreatic cancer, but also tumours that currently have no cure options. A video news release provides a synthesis of the ULISES project milestones.

27 Jun 2024

Adaptive therapy approach can reduce toxicity and drug resistance in ovarian cancer

Ovarian cancer, often diagnosed at an advanced stage, presents significant treatment challenges because patients tend to develop resistance to conventional therapies quickly.

26 Jun 2024

Melanoma messages: Social media a useful tool for skin cancer communication

Researchers assessed health communication messages that effectively educate the public and raise intentions to get skin exams.

26 Jun 2024

Breakthrough biomarker predicts recurrence risk in clear cell renal cancer

Researchers from the University of Michigan Health Rogel Cancer Center have discovered a biomarker that could help identify which renal cancer patients have a higher risk of recurrence.

25 Jun 2024

Combining CYFRA 21-1 with CXCR1 and cxcr2 levels for predicting recurrence in stage III squamous cell lung carcinoma

Despite efforts, tumor recurrence is diagnosed in 35–40% of patients with stage III squamous cell lung carcinoma (SCLC) during the first year after treatment.

25 Jun 2024

Senecavirus A could be a promising new therapeutic approach for hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a highly aggressive tumor with limited treatment options and high mortality.

25 Jun 2024

New ULTRA-PTT technology enhances the performance of conventional photothermal therapy

Professor Jin-ho Chang's research team from the Department of Electrical Engineering and Computer Science at DGIST (President Kun-woo Lee) developed "Ultrasound-assisted photothermal therapy (ULTRA-PTT)" technology that significantly enhances the performance of conventional photothermal therapy.

25 Jun 2024

Weill Cornell Medicine receives $1.5M grant to predict prostate cancer bone metastasis

Weill Cornell Medicine received a $1.5 million grant from the U.S. Department of Defense Prostate Cancer Research Program to develop new approaches for predicting the spread of cancer cells to the bone in men with prostate cancer, using tumor samples taken at early stages of the disease.

25 Jun 2024

FDA expands orphan drug designation for Roswell Park's brain cancer immunotherapy

The U.S. Food and Drug Administration (FDA) has expanded orphan drug designation for SurVaxM, a brain cancer immunotherapy born in the labs of Roswell Park Comprehensive Cancer Center.

25 Jun 2024

Open-source platform enables high-definition spatial transcriptomics

An open-source platform developed by researchers in Nikolaus Rajewsky's lab at the Max Delbrück Center creates molecular maps from patient tissue samples with subcellular precision, enabling detailed study and potentially enhancing routine clinical pathology. The study was published in "Cell."

25 Jun 2024

Multi-regional sampling uncovers hidden complexity in liver cancer

A study led by clinician-scientists and scientists from the National Cancer Centre Singapore (NCCS) and A*STAR's Genome Institute of Singapore (GIS) and funded by the National Research Foundation Singapore (NRF) has discovered unexpected molecular heterogeneity even within the same liver tumors. More than 40% of HCC harbors more than one molecular subtype within the same tumor and in these, the clinical outcomes for the patients are best predicted by the most aggressive subtype.

25 Jun 2024

New enzyme targets hold promise for cancer therapies

Researchers at Baylor College of Medicine and collaborating institutions have uncovered new potential therapeutic targets for cancer and new insights into existing cancer drug targets, expanding the breadth of possibilities for treating this disease. Using a comprehensive approach that included integrating proteomics, genomics and epigenomics data from 10 cancer types, the team identified protein and small protein or peptide targets in cancer tissues and validated many of them experimentally as promising candidates for therapeutic strategies. The study appeared in Cell.

25 Jun 2024

Tumor News and Research

Using liver biopsies to identify predictors of pancreatic cancer metastasis

AI identifies new high-risk subtype in endometrial cancer

Antibody-drug conjugate effective, less toxic for stage 1 HER2+ breast cancer

PFDN6 protein could be a new target for colorectal cancer treatment

Rice and MD Anderson collaborative harnesses engineering expertise for cancer solutions

Study identifies mechanism that impedes the effectiveness of melanoma therapies

Assessing clinical benefit and safety in trial waivers for treatment-refractory cancers

Uptick in early-onset gastrointestinal cancers raises the need for better prevention and diagnosis

Fighting cancer with nanoparticles

Adaptive therapy approach can reduce toxicity and drug resistance in ovarian cancer

Melanoma messages: Social media a useful tool for skin cancer communication

Breakthrough biomarker predicts recurrence risk in clear cell renal cancer

Combining CYFRA 21-1 with CXCR1 and cxcr2 levels for predicting recurrence in stage III squamous cell lung carcinoma

Senecavirus A could be a promising new therapeutic approach for hepatocellular carcinoma

New ULTRA-PTT technology enhances the performance of conventional photothermal therapy

Weill Cornell Medicine receives $1.5M grant to predict prostate cancer bone metastasis

FDA expands orphan drug designation for Roswell Park's brain cancer immunotherapy

Open-source platform enables high-definition spatial transcriptomics

Multi-regional sampling uncovers hidden complexity in liver cancer

New enzyme targets hold promise for cancer therapies

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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