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Cutting-edge NanoSIMS imaging sheds light on the progression of Parkinson's disease

Parkinson's disease is a complex neurodegenerative disorder that leads to the deterioration of specific types of neurons in the brain, resulting in a number of motor and non-motor symptoms.

29 Sep 2023

Stanford researchers uncover the science behind that 'tight skin' feeling

Researchers quantitatively investigated the mechanisms by which topical treatments modulate skin sensory perceptions, linking biomechanical changes in the skin to activation of cutaneous mechanoreceptors and subsequent neural signaling and correlating these changes to subjective sensory experiences reported by individuals.

29 Sep 2023

Aerosolized ACE2 neutralizes COVID-19 variants in lab and mice tests

Researchers from the University of Texas Southwestern have developed an aerosolized, mutated form of ACE2 that effectively neutralizes various SARS-CoV-2 variants in both cell cultures and mice. The study suggests that this modified ACE2 has promising preventive and therapeutic potential against COVID-19, especially with its easy aerosolized administration.

28 Sep 2023

Fatty liver disease susceptibility: study identifies interaction between estrogen receptor and genetic variant in women

Researchers pursued evidence of whether the interaction between the patatin-like phospholipase domain-containing 3 p.I148M variant and the female sex at the genetic and molecular level explains why premenopausal women remain protected against fatty liver disease, while a rapidly progressive disease ensues in some peri- and postmenopausal women.

28 Sep 2023

Zoonotic spillover safeguarding: computationally designed antigen targets range of coronaviruses

Researchers used an interdisciplinary approach incorporating phylogenetics, 3D protein modeling, and plasmid design to identify and computationally design an antigen representing the core of most currently known sarbecoviruses.

27 Sep 2023

Skin under pressure: tension affects skin's reaction to pollution

Researchers ratified previous findings that ozone (O3) exposure (an air pollutant) alters the antimicrobial peptide expression in the skin with and without tension.

27 Sep 2023

Could a mushroom-derived product be the future of lung cancer prevention?

Researchers find that a mushroom-derived product, GLSF, shows promise in reducing lung toxicity and tumor development induced by tobacco smoke carcinogens in mice. The study opens the door for future clinical trials, potentially offering a natural preventive measure against lung cancer.

26 Sep 2023

Smart capsules: the future of gut health diagnosis and monitoring?

Researchers discussed using smart and robotic capsules for sampling and sensing the gut.

26 Sep 2023

Scientists decode the marker protein that can be used to ‘‘see’’ neuroinflammation

Inflammation is the sign that our body is defending itself against an aggression. But when this response escalates, for example in the brain, it can lead to serious neurological or psychiatric diseases.

25 Sep 2023

How are SARS-CoV-2 variants outsmarting our immune system and vaccines?

Researchers use multiomics analysis to understand how SARS-CoV-2 variants, including Alpha, Delta, and Omicron, modulate the host's cellular responses and adapt to evade human immunity. The study highlights the potential for targeted therapies against both adaptive and innate immune responses.

25 Sep 2023

Researchers identify key regulators involved in genesis of multiple sclerosis lesions

By means of CRISPR screening, LMU researchers have provided the first ever comprehensive molecular characterization of T cell infiltration into the central nervous system of people with MS.

22 Sep 2023

New anticancer treatment technology targets cancer cell lysosomes and overcomes drug resistance

A groundbreaking anticancer treatment technology that selectively targets cancer cell lysosomes and overcomes drug resistance has been developed by Professor Ja-Hyoung Ryu and his research team in the Department of Chemistry at UNIST.

22 Sep 2023

Study demonstrates novel role of Axin1 in mediating intestinal homeostasis and microbiota

A groundbreaking study conducted by Jun Sun's research team at the University of Illinois Chicago has revealed a new and critical role of Axin1 in regulating intestinal epithelial development and microbial homeostasis.

22 Sep 2023

7 Tesla MRI reveals new insights into sleep regulation and light stimulation of the brain

A study conducted by researchers at the University of Liège (BE) Institute, using ultra-high field 7 Tesla MRI, are providing a better understanding of how sleep is regulated.

22 Sep 2023

Unlocking the power of mRNA vaccines: From COVID-19 to cancer and beyond

A comprehensive review in Signal Transduction and Targeted Therapy delves into the versatility and effectiveness of mRNA vaccines, from their game-changing role in COVID-19 to potential applications in cancer and rare diseases. Despite drawbacks like stability and high immunogenicity, advancements in vaccine technology have poised mRNA platforms as a robust tool for both preventive and therapeutic interventions.

21 Sep 2023

Rice engineers develop split gene-editing tool with enhanced control

To make a gene-editing tool more precise and easier to control, Rice University engineers split it into two pieces that only come back together when a third small molecule is added.

21 Sep 2023

New near-infrared activated photo-oxidants kill cancer cells without oxygen

A research team led by scientists from City University of Hong Kong (CityU) has achieved a significant breakthrough by inventing a new class of near-infrared-activated photo-oxidants that can effectively kill cancer cells without requiring oxygen.

20 Sep 2023

Subclonal neoantigens present a key roadblock in MMRd tumor immunotherapy success

Researchers evaluated sensitivity to immune checkpoint blockade (ICB) therapy.

20 Sep 2023

Transforming postpartum depression treatment with neurosteroids

A new study in Neuropsychopharmacology delves into the mechanisms of action of brexanolone, the first FDA-approved, rapid-acting antidepressant specifically for postpartum depression (PPD). The research highlights brexanolone's potential anti-inflammatory effects and its impact on GABAA receptors, offering insights into its efficacy and suggesting avenues for further study.

19 Sep 2023

New CAR T cell therapy approach minimizes severe side effects

In recent years, cancer researchers have hailed the arrival of chimeric antigen receptor T cell (CAR T) therapy, which has delivered promising results, transforming the fight against various forms of cancer. The process involves modifying patients' T-cells to target cancer cells, resulting in remarkable success rates for previously intractable forms of cancer.

19 Sep 2023

in vivo News and Research

Cutting-edge NanoSIMS imaging sheds light on the progression of Parkinson's disease

Stanford researchers uncover the science behind that 'tight skin' feeling

Aerosolized ACE2 neutralizes COVID-19 variants in lab and mice tests

Fatty liver disease susceptibility: study identifies interaction between estrogen receptor and genetic variant in women

Zoonotic spillover safeguarding: computationally designed antigen targets range of coronaviruses

Skin under pressure: tension affects skin's reaction to pollution

Could a mushroom-derived product be the future of lung cancer prevention?

Smart capsules: the future of gut health diagnosis and monitoring?

Scientists decode the marker protein that can be used to ‘‘see’’ neuroinflammation

How are SARS-CoV-2 variants outsmarting our immune system and vaccines?

Researchers identify key regulators involved in genesis of multiple sclerosis lesions

New anticancer treatment technology targets cancer cell lysosomes and overcomes drug resistance

Study demonstrates novel role of Axin1 in mediating intestinal homeostasis and microbiota

7 Tesla MRI reveals new insights into sleep regulation and light stimulation of the brain

Unlocking the power of mRNA vaccines: From COVID-19 to cancer and beyond

Rice engineers develop split gene-editing tool with enhanced control

New near-infrared activated photo-oxidants kill cancer cells without oxygen

Subclonal neoantigens present a key roadblock in MMRd tumor immunotherapy success

Transforming postpartum depression treatment with neurosteroids

New CAR T cell therapy approach minimizes severe side effects

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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