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Nighttime heart attacks cause less damage due to neutrophil circadian rhythms

Heart attacks that occur at night are less severe than those that strike during the day. A new study from the Centro Nacional de Investigaciones Cardiovasculares (CNIC) explains why. Published in the Journal of Experimental Medicine, the study led by Dr. Andrés Hidalgo's group at the CNIC shows that neutrophils-a type of white blood cell-have an internal clock that regulates their aggressiveness throughout the day and determines the extent of damage they cause to the heart after a heart attack.

12 Dec 2025

Exclusive licensing agreement accelerates PHD inhibitor development for anemia in CKD patients

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, and TaiGen Biotechnology, a listed discovery-based and market-focused pharmaceutical company, as well as TaiGen Biopharmaceuticals, its wholly-owned Beijing subsidiary (both referred to as "TaiGen"), today announced an exclusive pipeline out-licensing collaboration.

12 Dec 2025

AI-guided discovery of selective DGKα inhibitors to overcome checkpoint resistance in solid cancers

Insilico Medicine has developed a new class of small molecule inhibitors targeting diacylglycerol kinase alpha (DGKα) designed to restore T cell function and overcome resistance to immune checkpoint blockades in solid cancers.

12 Dec 2025

Mass General Brigham launches AI company to enhance clinical trial matching

Mass General Brigham is announcing the spinout of AIwithCare, a company founded by researchers from the health system who developed an artificial intelligence (AI) screening tool that significantly outperformed manual screening for determining a patient's eligibility and enrolling them in a clinical trial.

12 Dec 2025

Researchers identify chromatin accessibility changes driving stem cell transformation in MDS

Over the past few decades, advances in hematology have illuminated how a delicate balance between stem cell self-renewal and differentiation sustains healthy blood formation.

12 Dec 2025

EULAR proposes new guidance to assess disease activity in adult-onset Still’s disease

EULAR - The European Alliance of Associations for Rheumatology - has identified an unmet clinical need around the assessment of disease activity in people with adult-onset Still's disease.

12 Dec 2025

Scientists outline how organ rejuvenation strategies could solve the donor shortage

Researchers outline why organs from older donors are often discarded and identify the biological and immunological pathways that make them vulnerable to injury. They also highlight emerging rejuvenation technologies including machine perfusion, senotherapeutics, and regenerative strategies that could safely expand the donor pool.

11 Dec 2025

How ultra-processed foods shape Crohn’s disease risk and what dietary strategies can really help

This narrative review synthesizes evidence showing that higher intake of ultra-processed foods is consistently associated with increased Crohn’s disease risk, with mechanistic pathways implicating emulsifiers, carrageenan, maltodextrin, titanium dioxide, sweeteners and salt. It also highlights that minimally processed dietary strategies, including EEN and CDED, show therapeutic promise, particularly in pediatric Crohn’s disease.

11 Dec 2025

New findings show why the human intestine uniquely presents gluten to T cells

Human intestinal M cells function as dendritic cell-like antigen-presenting cells, displaying constitutive MHC-II activity and specialized machinery for processing gluten. Their ability to deamidate and present gliadin peptides positions them as key initiators of immune responses relevant to coeliac disease.

11 Dec 2025

Proton therapy improves survival in oropharyngeal cancer patients

A new study published today in The Lancet showed a significant survival benefit for patients with oropharyngeal cancers who were treated with proton therapy (IMPT) compared to those treated with traditional radiation therapy (IMRT).

11 Dec 2025

Study reveals shared genetic roots across multiple psychiatric disorders

Distinct psychiatric disorders have more in common biologically than previously believed, according to the largest and most detailed analysis to date of how genes influence mental illness.

11 Dec 2025

Review highlights emerging role of tumor MHC-II in shaping cancer immunotherapy outcomes

Cancer immunotherapy has transformed cancer treatment, yet many patients experience limited or short-lived responses due to immune evasion, tumor heterogeneity, and immune-related adverse events.

11 Dec 2025

New molecular ruler enables precise measurement of toxic Tau fibrils in fluid samples

Researchers have developed a new tool, FibrilPaint combined with the FibrilRuler test, that allows scientists to directly measure the length of toxic Tau amyloid fibrils in tiny fluid samples, from the earliest aggregation stages to mature fibrils and even at very low concentrations.

11 Dec 2025

Study reveals how Ebola and Marburg viruses damage the human gut

Ebola (EBOV) and Marburg virus (MARV) are highly lethal viruses that cause severe disease in infected patients by extensively damaging the body.

11 Dec 2025

Researchers identify enzyme linked to myelin damage and neurodegenerative conditions

Researchers at Oregon Health & Science University have identified a type of enzyme with a complicated name - cell migration inducing and hyaluronan-binding protein, or CEMIP - is associated with disorders ranging from multiple sclerosis to stroke to neurodegenerative conditions like Alzheimer's disease.

11 Dec 2025

Researchers discover the enzyme responsible for chromothripsis in cancer

University of California San Diego researchers have discovered the enzyme responsible for chromothripsis, a process in which a single chromosome is shattered into pieces and rearranged in a scrambled order, allowing cancer cells to rapidly evolve and become resistant to treatment.

11 Dec 2025

Blocking collagen signaling improves the delivery of macromolecular drugs in pancreatic cancer

Pancreatic cancer is one of the deadliest malignancies, with survival rates remaining dismally low despite major advances in oncology.

11 Dec 2025

Preoperative radiation may enhance treatment response in patients with HR-positive, HER2-negative breast cancer

Preoperative radiation improved T-cell infiltration (TCI) in patients with hormone receptor (HR)-positive, HER2-negative breast cancer when administered in combination with pembrolizumab (Keytruda) and chemotherapy and led to improved treatment responses prior to surgery, according to the results of the phase II P-RAD clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

11 Dec 2025

Missing piece of myelin results in slower, less consistent signal transmission to the brain

Our nerve cells are surrounded by a protective layer (myelin). This protective layer allows signals to pass between cells incredibly quickly.

11 Dec 2025

Shared genetic roots of 14 psychiatric disorders revealed

Researchers from the Psychiatric Genomics Consortium (PGC) report that most genetic influences on mental illness are shared across diagnostic categories, revealing a more interconnected biological landscape than traditional classifications suggest.

11 Dec 2025

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B Cell News and Research

Nighttime heart attacks cause less damage due to neutrophil circadian rhythms

Exclusive licensing agreement accelerates PHD inhibitor development for anemia in CKD patients

AI-guided discovery of selective DGKα inhibitors to overcome checkpoint resistance in solid cancers

Mass General Brigham launches AI company to enhance clinical trial matching

Researchers identify chromatin accessibility changes driving stem cell transformation in MDS

EULAR proposes new guidance to assess disease activity in adult-onset Still’s disease

Scientists outline how organ rejuvenation strategies could solve the donor shortage

How ultra-processed foods shape Crohn’s disease risk and what dietary strategies can really help

New findings show why the human intestine uniquely presents gluten to T cells

Proton therapy improves survival in oropharyngeal cancer patients

Study reveals shared genetic roots across multiple psychiatric disorders

Review highlights emerging role of tumor MHC-II in shaping cancer immunotherapy outcomes

New molecular ruler enables precise measurement of toxic Tau fibrils in fluid samples

Study reveals how Ebola and Marburg viruses damage the human gut

Researchers identify enzyme linked to myelin damage and neurodegenerative conditions

Researchers discover the enzyme responsible for chromothripsis in cancer

Blocking collagen signaling improves the delivery of macromolecular drugs in pancreatic cancer

Preoperative radiation may enhance treatment response in patients with HR-positive, HER2-negative breast cancer

Missing piece of myelin results in slower, less consistent signal transmission to the brain

Shared genetic roots of 14 psychiatric disorders revealed

Using single B cell screening to boost antibody discovery eBook

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

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