Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

New compound targets the neuronal epigenome to treat Alzheimer's disease

A team from the University of Barcelona has designed and validated in animal models an innovative compound with a pioneering mechanism of action for the treatment of Alzheimer's disease.

19 Mar 2026

Python blood compound could lead to new weight loss therapies

University of Colorado Boulder researchers have discovered an appetite-suppressing compound in python blood that helps the snakes consume enormous meals and go months without eating yet remain metabolically healthy.

19 Mar 2026

Menopause may raise women’s Alzheimer risk earlier than doctors once thought

This review argues that women’s higher Alzheimer disease risk may be shaped in part by midlife neuroendocrine aging, especially the menopause transition, rather than by longevity alone. It highlights early menopause, bilateral oophorectomy, vasomotor symptoms, and midlife cognitive changes as underinvestigated but potentially important risk markers, while calling for sex-specific, biomarker-driven prevention strategies.

18 Mar 2026

New data hub aims to advance alternatives to animal testing

A research team at NYU Langone Health and Sage Bionetworks has been awarded a $25 million grant to establish the data hub and coordinating center for the National Institutes of Health's Complement-Animal Research in Experimentation (Complement-ARIE) program.

18 Mar 2026

Muscle-repairing macrophages trigger heterotopic ossification in mice

We have identified a macrophage population "Mrep" that plays an essential role in muscle repair. However, in Fibrodysplasia ossificans progressiva (FOP), Mrep functions as a pathogenic cell that triggers heterotopic ossification.

18 Mar 2026

Key gene mutation disrupts the brain’s ability to update beliefs in schizophrenia patients

One of the symptoms of schizophrenia is difficulty incorporating new information about the world. This can lead patients to struggle with making decisions and, eventually, to lose touch with reality.

18 Mar 2026

Study identifies brain pathway crucial for proper functioning of working memory

Working memory is a cognitive function that is essential for carrying out everyday activities and temporarily retaining information.

17 Mar 2026

Study reveals limitations of large language models in medical diagnostics

Artificial intelligence (AI) is rapidly transforming healthcare. AI systems can now detect diabetic eye disease from retinal photos and analyze CT images for signs of early-stage lung cancers and stroke.

16 Mar 2026

Protein MIIP suppresses colorectal cancer by regulating immune cell signaling

Colorectal cancer remains one of the leading causes of cancer-related mortality worldwide, largely due to metastasis and limited responses to immunotherapy in most patients.

16 Mar 2026

Researchers identify cellular drivers of gut scarring in Crohn’s disease

As inflamed regions of the gut form scar tissue, the space within the gut lumen becomes smaller and more restricted, leading to symptoms of gut obstruction.

16 Mar 2026

New AI system reduces pathologist workload while maintaining diagnostic accuracy

Artificial intelligence could make cancer diagnosis safer and fairer by learning when to defer to human pathologists without overloading them, according to researchers from the University of Surrey and Monash University.

13 Mar 2026

Blood protein structure changes may enable earlier detection of Alzheimer’s

Advanced proteomics and AI reveal blood protein changes, offering insights into early Alzheimer's detection and differentiation from mild cognitive impairment.

13 Mar 2026

New study identifies specific brain cells most vulnerable to ALS and dementia

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) belong to a spectrum of neurodegenerative diseases with overlapping symptoms, characterized by muscle wasting, paralysis, dementia, and other serious impairments.

12 Mar 2026

Blood test marker p-tau217 helps detect early dementia risk in cognitively healthy older women

A long-term study of 2,766 women in the Women’s Health Initiative Memory Study found that higher baseline plasma p-tau217 levels were associated with a greater risk of developing mild cognitive impairment or probable dementia.

11 Mar 2026

Review explores how generative AI could support precision oncology decision-making

A narrative review examines how generative AI tools such as large language models and vision-language models could assist precision oncology by interpreting genomic data, matching patients to clinical trials, and synthesizing complex clinical information. The authors emphasize governance, human oversight, and retrieval-based safeguards to ensure these systems are deployed safely in cancer care.

11 Mar 2026

How the aging gastrointestinal tract drives age-related cognitive decline

We become forgetful as we age. This is often seen as a universal truth, but in fact it is far from universal: some people remain incredibly sharp at 100 years old, while others experience memory loss starting in middle age.

11 Mar 2026

Researchers develop DNA aptamer to detect Alzheimer's biomarkers

With aging populations on the rise, the need for better tools to diagnose and monitor Alzheimer's disease (AD), the most common cause of dementia, has never been more urgent.

10 Mar 2026

New peptide fragments teach the gut to tolerate food

In little moments like when sipping coffee or licking an ice cream cone, it doesn't seem like your body is pulling off a biological miracle. But it is. That cookie is not you-yet when you put it in your mouth, your body is able to tolerate it and process it without any detriment to your health in a process called oral tolerance. How does the human body make that decision between tolerance and rejection?

9 Mar 2026

How somatic mutations shape disease and reveal new drug targets

Researchers reviewed how somatic mutations accumulate in normal and diseased tissues, showing that natural selection can expand clones that influence disease risk, tissue adaptation, or cellular resilience. The study proposes somatic genomics as a powerful strategy to uncover disease mechanisms and identify new therapeutic targets across multiple conditions.

8 Mar 2026

Can one AI analyze all medical scans? MedVersa shows promise across multiple imaging tasks

esearchers developed MedVersa, a generalist multimodal AI model trained on tens of millions of medical imaging instances to perform diverse radiology tasks within a single framework. The model matched or exceeded specialist AI systems across several benchmarks and produced radiology reports comparable to human reports in many cases while improving reporting efficiency.

8 Mar 2026