Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

Mechanical factors play a key role in the natural growth of human organs

In addition to chemical factors, mechanical influences play an important role in the natural growth of human organs such as kidneys, lungs and mammary glands - but also in the development of tumors.

13 Jul 2021

New approach that uses machine learning could transform drug development

Writing in the July 12, 2021 online issue of Nature Communications, researchers at University of California San Diego School of Medicine describe a new approach that uses machine learning to hunt for disease targets and then predicts whether a drug is likely to receive FDA approval.

12 Jul 2021

Researchers reveal underlying genetic pathway behind neurological dysfunction of Rett syndrome

Medical researchers led by Kyushu University have revealed a possible underlying genetic pathway behind the neurological dysfunction of Rett syndrome.

2 Jul 2021

Experts reveal ways of dealing with fear and provide scope for confidence

Terrorism, climate change and now a pandemic - worries and fears shape the everyday lives of many people. The latest issue of the Science Magazine BfR2GO from the German Federal Institute for Risk Assessment (BfR) is dedicated to fear, while at the same time embarking on a search for confidence. Scientists from many spheres have their chance to speak and categorize the concepts in a clear way.

2 Jul 2021

Loss of PTHrP hormone can prevent metastases, improve survival in mice with pancreatic cancer

Lowering levels of a hormone called PTHrP can prevent metastases and improve survival in mice with pancreatic cancer and could lead to a new way to treat patients, according to a study from cancer researchers at Columbia University Vagelos College of Physicians and Surgeons and Herbert Irving Comprehensive Cancer Center and with collaborators at the University of Pennsylvania.

1 Jul 2021

Scientists mimic the natural development of mammal using stem cells

The tiny mouse embryo has a heart that beats. Its muscles, blood vessels, gut and nervous system are beginning to develop. But this embryo is unusual: It was made in a lab, out of mouse embryonic stem cells, and represents the most sophisticated in vitro (in a dish) model of a mammal ever so created.

29 Jun 2021

Study identifies the cell of origin of medulloblastoma

The study was conducted by an international collaboration involving the research team led by Luca Tiberi of the Armenise-Harvard Laboratory of Brain Cancer at the Department of Cellular, computational and integrative biology - Cibio of UniTrento, the Paris Brain Institute-Institut du Cerveau at Sorbonne Université in Paris, the Hopp Children´s Cancer Center (KiTZ) in Heidelberg, Germany, and Sapienza University in Rome.

24 Jun 2021

MMRI expert receives diversity grant for research on autism, heart disease

Does a connection exist between the development of heart disease and autism? That's a question Dr. Maria Kontaridis, Executive Director and Gordon K. Moe Professor at the Masonic Medical Research Institute (MMRI), and her team have been actively investigating thanks to a grant from the American Heart Association (AHA).

23 Jun 2021

Study determines the mechanism behind respiratory inflammation and finds effective treatment

Applied Biological Laboratories (Applied Bio), a biopharmaceutical company focused on the respiratory disease market, announced that its study published online in Immunology, Inflammation and Disease was able to determine the mechanism behind respiratory inflammation and treat it effectively with Biovanta(TM), a 100% naturally derived, over-the-counter (OTC) drug for cold, cough and sore throat.

22 Jun 2021

New human organoid mimics the earliest developmental steps of the nervous system in embryos

The progression from a round ball of cells to an embryo with a head and a tail is one of the most critical steps in an organism's development. But just how cells first start organizing themselves with directionality along this head-to-tail axis is hard to study because it happens in the earliest days of embryonic development, in the confines of a mammal's uterus.

22 Jun 2021

Researchers decode the mechanisms of cell renewal process

The human intestine is made up of more than 40 square meters of tissue, with a multitude of folds on its internal surface that resemble valleys and mountain peaks in order to increase the absorption of nutrients.

22 Jun 2021

Researchers identify four substances that inhibit SARS-CoV-2 replication in cells

Researchers from the German Center for Infection Research at Charité - Universitätsmedizin Berlin and the University of Bonn have examined the way in which SARS-CoV-2 reprograms the metabolism of the host cell in order to gain an overall advantage.

21 Jun 2021

Combination of interferon-α and nafamostat inhibits SARS-CoV-2 in vivo

A new study, released as a preprint on bioRxiv* server, shows that a combination of the biological interferon-α and the small molecule nafamostat are effective against SARS-CoV-2 infection in vitro, as well as in vivo.

18 Jun 2021

Novel drug class shows potential to treat cancer patients with faulty BRCA genes

Scientists have identified a new class of targeted cancer drugs that offer the potential to treat patients whose tumors have faulty copies of the BRCA cancer genes.

17 Jun 2021

How the common cold can provide protection against COVID-19

In a recent study, researchers found that prior infection with the rhinovirus can provide a more effective immune response against SARS-CoV-2 infection.

17 Jun 2021

Researchers study what happens in brain cells affected by Alzheimer's disease

Studies on tissue from patients and mini-brains made from stem cells shed light on the disease.

14 Jun 2021

Researchers identify a novel host-directed therapeutic approach to COVID-19

Researchers in the UK have demonstrated the potential of modulating the expression of angiotensin-converting enzyme 2 (ACE2) as a novel host-directed therapeutic approach to protecting against coronavirus disease 2019 (COVID-19).

8 Jun 2021

Sphere Fluidics and ClexBio introduce CYTRIX Microfluidic Hydrogel Kit

Sphere Fluidics, a company commercializing single cell analysis systems underpinned by its patented picodroplet technology, and ClexBio, a pioneer in solutions for tissue engineering and single-cell techniques, today announced the launch of the biocompatible CYTRIX Microfluidic Hydrogel Kit.

From Sphere Fluidics 7 Jun 2021

Single mutation to bat virus spike protein allows cell entry using human ACE2

In a paper recently uploaded to the preprint server bioRxiv by Kirchhoff et al. (May 31st, 2021) it is demonstrated that a single mutation to the RaTG13 spike protein results in significantly greater affinity towards the human receptor, indicating that the presence of a positively charged amino group at this position better facilitates interaction with the human ACE2 receptor, and helping to identify other viruses with zoonotic potential.

3 Jun 2021

AMSBIO's custom lentivectors for labeling organoids

AMSBIO have supplied custom lentivectors to Francesco Pampaloni and his team at the Buchmann Institute for Molecular Life Sciences in Frankfurt, Germany allowing them to visualize cell nuclei and F-actin cytoskeleton in their organoids.

From AMS Biotechnology 1 Jun 2021