Preclinical News and Research

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GB Sciences announces preclinical results of promising formulations for Parkinson's disease

GB Sciences, Inc. announced significant preclinical results for their Parkinson's disease ("PD") formulations from the midterm report for their preclinical study being performed by Dr. Lee Ellis of the National Research Council in Halifax, Nova Scotia, CANADA.

22 Dec 2019

Fibroblasts involved in healing wounds play a devastating role in breast cancer development

The connective tissue cells known as fibroblasts are vitally important for our recovery from injury. Sensing tissue damage, they gravitate to the site of a wound, instigating an inflammatory response that mends damaged tissue.

19 Dec 2019

Scientists develop computationally inspired method for preclinical study of anxiety

Nearly 40 million people in the U.S. have an anxiety disorder. While treatment options exist, treatment success varies, and many people do not respond to treatment until weeks or months after they begin anti-depressants

18 Dec 2019

Study finds new drivers of destructive inflammation

Scientists describe in Nature Immunology an entirely new molecular process in mice that triggers T cell-driven inflammation and causes different auto-immune diseases.

17 Dec 2019

Contribution of suicide to opioid-related deaths may be overstated, study suggests

The study is the first to use national data on opioid overdose deaths between 2000 and 2017 to find out what share of these deaths in individuals age 15 and older were unintentional, due to suicide, or of undetermined intent.

17 Dec 2019

MR Solutions participates in the first SFNano & C’Nano joint meeting 2019

UK based MR Solutions presented a simultaneous 7T PET/MRI preclinical imaging system optimized for nanoparticle imaging to the first joint annual congress of the French Nanomedicine Society (SFNano), and the French national Competency Cluster in Nanoscience C’Nano which was held in Dijon in early December.

From MR Solutions 17 Dec 2019

Spine surgery is safe in advanced-age patient group

Spine surgeons from seven institutions in Sapporo, Hokkaido, Japan, conducted a multicenter, prospective study of spine surgeries performed in patients 80 years of age and older.

17 Dec 2019

Study: Blocking IL1α protein decreases severity of inflammation in Crohn's disease

Investigators at the Case Western Reserve University School of Medicine discovered that blocking interleukin-1α (IL1α), a protein that controls inflammation in the gut, markedly decreases the severity of intestinal inflammation in a mouse model of Crohn's disease (CD).

17 Dec 2019

Tackling antibiotic resistance head-on with CRISPR

With modern advances in genetic engineering occurring almost every day, the latest discovery concerns antibiotic resistance. Using the powerful gene editor CRISPR, scientists reported the development of a gene-drive system that is 100 times as efficient as other current systems at inactivating a specific bacterial gene responsible for making the bacterium antibiotic-resistant and which is present as multiple copies within the same bacterial cell.

16 Dec 2019

Super-resolution localization photoacoustic microscopy can find blocked or burst blood vessels

200 years ago, a doctor from France used a stethoscope for the first time and countless efforts to observe human body have been made since then. Up to now, the best tool that provides anatomical, functional, and molecular information of human and animal is the photoacoustic microscopy.

16 Dec 2019

New strategy could prevent side effects of targeted cancer treatment

Targeted, highly effective cancer treatments often produce debilitating side effects. This is the case with one commonly used therapy which works by blocking the epidermal growth factor receptor, a protein that stimulates cell proliferation.

13 Dec 2019

New methodologies could help premature babies breathe easy

When a premature baby is born, the immediate challenge is to ensure it breathes easily without outside help. A new study shows that by carefully supplying 100% oxygen to these fragile scraps of humanity, independent breathing can be initiated much faster.

12 Dec 2019

Study shows unexpected mechanism for lipid acquisition by breast cancer cells

High-fat diets and obesity have been shown to increase the risk of breast cancer and worsen outcomes and prognosis of breast cancer patients. A team of researchers from Dartmouth and Dartmouth-Hitchcock Norris Cotton Cancer Center led by William Kinlaw III, MD, sought to understand how fat from the diet might influence breast cancer cells.

12 Dec 2019

Scientists use novel technology for opening blood-brain barrier with implantable ultrasound

One of most potent drugs for treatment of glioblastoma, the most deadly type of brain tumor, can't be used in patients because of two problems. First, it can't reach its target because it's blocked by the blood-brain barrier, a microscopic structure that protects the brain from toxins in the blood. And the conventional formulation for this drug is toxic to the brain.

12 Dec 2019

Diet high in refined carbohydrates may trigger insomnia

An estimated 30% of adults experience insomnia, and a new study by researchers at Columbia University Vagelos College of Physicians and Surgeons suggests that diet may be partly to blame.

11 Dec 2019

New drug combo promises help for triple negative breast cancer patients

A new preclinical study on triple negative breast cancer (TNBC) reports that an experimental polo-like kinase 1 (PLK1) inhibitor shrank tumor four times more powerfully when used along with standard drugs than alone. The study, reported in the journal PLOS ONE, opens up a new door of opportunity for patients with this disease.

11 Dec 2019

Researchers develop 'scar in a dish' model to closely mimic progressive organ scarring

Every organ in the body is capable, to some extent, of repairing itself after an injury. As part of this process, scar tissue forms and then recedes to make room for normal tissue when healing is complete.

11 Dec 2019

UMSOM researchers to test the safety, tolerability of prototype Shigella-ETEC vaccine

Each year, millions of people contract serious diarrheal illnesses typically from contaminated food and water. Among the biggest causes of diarrheal diseases are the bacteria Shigella and enterotoxigenic Escherichia coli, and researchers at the University of Maryland School of Medicine are testing a vaccine designed to offer protection against these serious pathogens.

10 Dec 2019

Combination regimen shows promising results in preclinical models of triple negative breast cancer

Tumor volume in a preclinical model of triple negative breast cancer (TNBC) was reduced four times more when an experimental polo-like kinase 1 (PLK1) inhibitor was combined with a standard-of-care chemotherapeutic agent than when the agent was used alone.

10 Dec 2019

Mitochondrial dysfunction may underlie prolonged muscle weakness after sepsis

Damage to energy-producing mitochondria may underlie prolonged muscle weakness following a sepsis-like condition in mice, according to a new study published today in eLife.

10 Dec 2019

Preclinical News and Research

GB Sciences announces preclinical results of promising formulations for Parkinson's disease

Fibroblasts involved in healing wounds play a devastating role in breast cancer development

Scientists develop computationally inspired method for preclinical study of anxiety

Study finds new drivers of destructive inflammation

Contribution of suicide to opioid-related deaths may be overstated, study suggests

MR Solutions participates in the first SFNano & C’Nano joint meeting 2019

Spine surgery is safe in advanced-age patient group

Study: Blocking IL1α protein decreases severity of inflammation in Crohn's disease

Tackling antibiotic resistance head-on with CRISPR

Super-resolution localization photoacoustic microscopy can find blocked or burst blood vessels

New strategy could prevent side effects of targeted cancer treatment

New methodologies could help premature babies breathe easy

Study shows unexpected mechanism for lipid acquisition by breast cancer cells

Scientists use novel technology for opening blood-brain barrier with implantable ultrasound

Diet high in refined carbohydrates may trigger insomnia

New drug combo promises help for triple negative breast cancer patients

Researchers develop 'scar in a dish' model to closely mimic progressive organ scarring

UMSOM researchers to test the safety, tolerability of prototype Shigella-ETEC vaccine

Combination regimen shows promising results in preclinical models of triple negative breast cancer

Mitochondrial dysfunction may underlie prolonged muscle weakness after sepsis

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