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$6 million grant to fund research investigating the role of immune system in heart failure

A new grant for researchers at Washington University School of Medicine in St. Louis will fund research investigating the role of the immune system in heart failure. Finding ways to harness beneficial immune cells could lead to new therapies that encourage the heart to heal after injuries.

2 May 2022

Antibiotics may disrupt microbiome to cause recurrent UTIs

A study by researchers at Washington University School of Medicine in St. Louis and the Broad Institute of MIT and Harvard suggests that women who get recurrent urinary tract infections (UTIs) may be caught in a vicious cycle in which antibiotics given to eradicate one infection predispose them to develop another.

2 May 2022

Dapagliflozin did not reduce risks in patients hospitalized with COVID-19

In a recent randomized clinical trial of hospitalized patients with COVID-19 and cardio-metabolic risk factors, the sodium-glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin did not significantly reduce patients' risk of organ failure, kidney problems, or death compared with placebo, although numerically fewer participants treated with dapagliflozin experienced these outcomes. The findings are published in CJASN.

29 Apr 2022

Study illustrates how a protein complex controls genome organization to maintain lineage fidelity

Understanding the molecular mechanisms that specify and maintain the identities of more than 200 cell types of the human body is arguably one of the most fundamental problems in molecular and cellular biology, with critical implications for the treatment of human diseases. Central to the cell fate decision process are stem cells residing within each tissue of the body.

29 Apr 2022

Study shows polysaccharides of seaweed and abalone inhibit SARS-CoV-2 in vitro

A new study published in Marine Drugs evaluated the inhibitory effect of three polysaccharides, crude polysaccharide from Hizikia fusiforme (CPHF), crude polysaccharide from Sargassum horneri (CPSH), and crude polysaccharide from abalone viscera (CPAV) on the propagation of SARS-CoV-2 in vitro.

28 Apr 2022

Black and Hispanic people get the same benefits from CAR-T therapy as white patients

CAR-T therapy, a form of immunotherapy that revs up T-cells to recognize and destroy cancer cells, has revolutionized the treatment of blood cancers, including certain leukemias, lymphomas, and most recently, multiple myeloma.

28 Apr 2022

How do mosquito bites affect immunity?

A new study looks at the immunomodulatory effects of mosquito bites, using Aedes aegypti as the model species and humans as the host.

28 Apr 2022

Review aims to deepen the understanding of the role of natural killer cells in COVID-19

In a recent study published in Biomedicines, researchers explored the utility of natural killer (NK) cells in coronavirus disease 2019 (COVID-19).

28 Apr 2022

The added value of adequate immune fitness to the existing approaches to pandemic preparedness

Researchers described two studies, the CLOFIT retrospective study and the COTEST real-time study, that investigated if maintaining adequate immune fitness could significantly add to the current strategies of preparedness for COVID-19 and other pandemics.

28 Apr 2022

Exploring oncolytic viral therapeutics and immunotherapies derived from DNA and RNA

A new review initially described the developments in cancer-based medicines that included vaccinations, vector-based techniques, and genome injection using DNA and RNA-based nucleic acid therapeutics.

28 Apr 2022

Green tea catechin as pan-coronavirus attachment inhibitor

In a recent study posted to the Research Square* preprint server, researchers assessed the impact of green tea catechin epigallocatechin gallate (EGCG) on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

27 Apr 2022

Study describes ultra-structure of Nipah virus surface glycoprotein

A team of US-based scientists has recently demonstrated the cryo-electron microscopic structure and antigenicity of the attachment glycoprotein of the Nipah virus.

27 Apr 2022

Researchers show how chronic pain leads to maladaptive anxiety in mice

Hokkaido University researchers have shown how chronic pain leads to maladaptive anxiety in mice, with implications for treatment of chronic pain-related psychiatric disorders in humans.

27 Apr 2022

New insights could lead to better treatments for Dravet syndrome and related conditions

Children with Dravet syndrome, a severe form of epilepsy that begins in infancy, experience seizures, usually for their entire life.

27 Apr 2022

New insight into the body’s response to tuberculosis may help design a more effective vaccine

More than 1.7 billion people - or a quarter of the world's population - are infected with Mycobacterium tuberculosis, the bacterial strain that causes tuberculosis (TB).

27 Apr 2022

Researchers identify four new target molecules for future personalized MS treatment

Currently available therapies to treat multiple sclerosis (MS) lack precision and can lead to serious side effects.

27 Apr 2022

Gene discovery could pave the way for new and more effective treatments for lupus

Researchers from The Australian National University have identified a gene called TLR7 that, when over-activated, is responsible for causing lupus, an autoimmune disease that can be life-threatening in severe cases.

27 Apr 2022

St. John's wort extract shows potent antiviral activity against SARS-CoV-2 and its variants

Scientists from Germany have recently identified Hypericum perforatum, a widespread herbal plant known as St. John's wort, as a potential antiviral agent against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The study is published in the journal Pharmaceuticals.

27 Apr 2022

New discovery about nature’s ‘high-end machinery’ could have big implications for biology

Working with tiny bacteria, Michigan State University researchers led by Lee Kroos have made a discovery that could have big implications for biology.

26 Apr 2022

Johns Hopkins scientists receive $7.8 million funding from Break Through Cancer

The Johns Hopkins Kimmel Cancer Center and the Departments of Gynecology/Obstetrics, Neurosurgery and Pathology have been awarded more than $7.8 million for novel, multicenter projects designed to intercept and find cures for several deadly cancers, including pancreatic cancer, ovarian cancer, and the brain cancer known as glioblastoma.

26 Apr 2022

Therapeutics News and Research

$6 million grant to fund research investigating the role of immune system in heart failure

Antibiotics may disrupt microbiome to cause recurrent UTIs

Dapagliflozin did not reduce risks in patients hospitalized with COVID-19

Study illustrates how a protein complex controls genome organization to maintain lineage fidelity

Study shows polysaccharides of seaweed and abalone inhibit SARS-CoV-2 in vitro

Black and Hispanic people get the same benefits from CAR-T therapy as white patients

How do mosquito bites affect immunity?

Review aims to deepen the understanding of the role of natural killer cells in COVID-19

The added value of adequate immune fitness to the existing approaches to pandemic preparedness

Exploring oncolytic viral therapeutics and immunotherapies derived from DNA and RNA

Green tea catechin as pan-coronavirus attachment inhibitor

Study describes ultra-structure of Nipah virus surface glycoprotein

Researchers show how chronic pain leads to maladaptive anxiety in mice

New insights could lead to better treatments for Dravet syndrome and related conditions

New insight into the body’s response to tuberculosis may help design a more effective vaccine

Researchers identify four new target molecules for future personalized MS treatment

Gene discovery could pave the way for new and more effective treatments for lupus

St. John's wort extract shows potent antiviral activity against SARS-CoV-2 and its variants

New discovery about nature’s ‘high-end machinery’ could have big implications for biology

Johns Hopkins scientists receive $7.8 million funding from Break Through Cancer

Industry Focus eBook - Cell biology (5th edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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