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NIH grant renewed to continue work at the Penn Center for Musculoskeletal Disorders

Long-time funding for work at the Penn Center for Musculoskeletal Disorders has been renewed for another five years by the National Institute of Arthritis, Musculoskeletal, and Skin Diseases of the National Institutes of Health.

25 Aug 2021

Study finds a new line of drugs to stimulate myelin repair in multiple sclerosis

In the nearly 1 million Americans living with multiple sclerosis, the fatty substance that insulates the nerves of the central nervous system—called myelin—is damaged.

24 Aug 2021

First-in-kind kidney cancer drug developed at UTSW receives FDA approval

A first-in-kind kidney cancer drug developed from laboratory and translational studies conducted at UT Southwestern Medical Center received approval from the Food and Drug Administration, providing a new treatment for patients with familial kidney cancer.

24 Aug 2021

Researchers discover molecule that plays an important role in sperm motility regulation

About 120 million unintended pregnancies occurred each year between 2015 and 2019 worldwide. While there are oral contraceptives for women, the development of oral contraceptives for men has not been successful.

24 Aug 2021

New mathematical model can predict the optimum exercise regime for building muscle

Researchers have developed a mathematical model that can predict the optimum exercise regime for building muscle.

23 Aug 2021

Preclinical study validates crucial role of the spleen in cardiac repair

Although we can survive without a spleen, evidence continues to mount that this abdominal organ plays a more valuable role in our physiological defenses than previously suspected.

23 Aug 2021

New study identifies novel compound as promising pan-coronavirus drug candidate

A recent study describes a novel compound with frameshifting capability against MERS-CoV, inhibiting viral propagation within infected cells.

23 Aug 2021

Nanotechnology provides novel solutions against zoonotic viruses

Therefore, scientists functionalize nanoparticles to act against these pathogenic viruses in a clinical strategy. In a recent review published in the journal Microbial Pathogenesis, researchers look at the novel solutions against zoonotic viruses provided by nanotechnology.

23 Aug 2021

SARS-CoV-2 mutations alter dynamics of neutralizing antibodies

A new study describes how monoclonal antibodies raised against SARS-CoV-2 are affected by mutations in the antibody binding site.

20 Aug 2021

SARS-CoV-2 lambda variant escapes immune response via spike mutations

A new study explores the mechanism by which the SARS-CoV-2 lambda variant has acquired immune evasion capabilities above that of the wildtype.

20 Aug 2021

Researchers identify key protein that plays an essential role in male fertility

Mammalian sperm cannot fertilize an egg from the get-go. It's an ability acquired only after insemination, during passage through the female reproductive tract, and requires two consecutive, time-sensitive processes to provide sperm with the physical and biochemical traits necessary to complete their fundamental job.

20 Aug 2021

Study points to a novel strategy for developing broad-spectrum vaccines against coronaviruses

Scientists from Duke-NUS Medical School and the National Centre for Infectious Diseases (NCID) found that 2003 SARS survivors who have been vaccinated with the Pfizer-BioNTech mRNA vaccine produced highly potent functional antibodies that are capable of neutralizing not only all known SARS-CoV-2 variants of concerns (VOCs) but also other animal coronaviruses that have the potential to cause human infection.

20 Aug 2021

Urine test for detecting chronic kidney disease is not used enough in high-risk groups, study suggests

Despite their higher risk of chronic kidney disease, people with hypertension or diabetes usually are not given a simple test for protein in the urine to screen for this potentially deadly disorder, according to a study led by researchers at Johns Hopkins Bloomberg School of Public Health.

19 Aug 2021

Phase I clinical study evaluates safety and pharmacokinetics of ExeVir's COVID-19 neutralizing antibody

ExeVir, which is developing single domain antibody therapies providing broad protection against viral infections, today announces that the first subjects have been dosed in a Phase I clinical study of XVR011, its llama-derived antibody for the treatment and prevention of COVID-19.

19 Aug 2021

A spike-derived epitope YLQ induces robust polyfunctional cytotoxic T cell responses in COVID-19 recovered individuals

The findings reveal that the dominant spike-derived epitope induces polyfunctional CD8+ T cell response in coronavirus disease 2019 (COVID-19) recovered individuals. The study is currently available on the bioRxiv* preprint server.

18 Aug 2021

Designing antimalarials with multiple targeting mechanisms of action

Malaria remains a serious global health threat. While the current discoveries of antimalarials are almost totally focused on single mode-of-action inhibitors, multi-targeting inhibitors are highly desired to overcome the increasingly serious drug resistance.

18 Aug 2021

Children’s Hospital Colorado helps prove safety and efficacy of CF treatment in younger pediatric patients

Researchers at the Children's Hospital Colorado Breathing Institute, the largest pediatric cystic fibrosis (CF) clinical care center in the U.S., participated in the pivotal international multi-center Phase 3 clinical trial, sponsored by Vertex Pharmaceuticals Incorporated, leading to FDA approval of TRIKAFTA (elexacaftor/tezacaftor/ivacaftor), a highly effective CF treatment, for patients ages 6 through 11 who have at least one copy of the F508del mutation.

17 Aug 2021

Research shines light on histamine as a potential key player in depression

Bodily inflammation dampens levels of a ‘feel-good molecule’ and antidepressants’ ability to boost them, according to new research in mice.

17 Aug 2021

Study identifies mechanism of resistance and presents a much-needed target for advanced leukemias

Too many "exhausted" T cells left in the wake of aggressive chemotherapy regimens for patients with advanced chronic lymphocytic leukemia (CLL) make it more challenging for chimeric antigen receptor (CAR) T cell therapy to do its job.

16 Aug 2021

Researchers assess the genetic features of T-cell immunity development to SARS-CoV-2 variants

The continuing emergence of new SARS-CoV-2 mutations allows the virus to spread more effectively and evade antibodies. However, it is unclear whether new strains are capable of evading T-cell immunity - one of the body's main lines of defense against COVID-19.

16 Aug 2021

Molecule News and Research

NIH grant renewed to continue work at the Penn Center for Musculoskeletal Disorders

Study finds a new line of drugs to stimulate myelin repair in multiple sclerosis

First-in-kind kidney cancer drug developed at UTSW receives FDA approval

Researchers discover molecule that plays an important role in sperm motility regulation

New mathematical model can predict the optimum exercise regime for building muscle

Preclinical study validates crucial role of the spleen in cardiac repair

New study identifies novel compound as promising pan-coronavirus drug candidate

Nanotechnology provides novel solutions against zoonotic viruses

SARS-CoV-2 mutations alter dynamics of neutralizing antibodies

SARS-CoV-2 lambda variant escapes immune response via spike mutations

Researchers identify key protein that plays an essential role in male fertility

Study points to a novel strategy for developing broad-spectrum vaccines against coronaviruses

Urine test for detecting chronic kidney disease is not used enough in high-risk groups, study suggests

Phase I clinical study evaluates safety and pharmacokinetics of ExeVir's COVID-19 neutralizing antibody

A spike-derived epitope YLQ induces robust polyfunctional cytotoxic T cell responses in COVID-19 recovered individuals

Designing antimalarials with multiple targeting mechanisms of action

Children’s Hospital Colorado helps prove safety and efficacy of CF treatment in younger pediatric patients

Research shines light on histamine as a potential key player in depression

Study identifies mechanism of resistance and presents a much-needed target for advanced leukemias

Researchers assess the genetic features of T-cell immunity development to SARS-CoV-2 variants

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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