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New monoclonal antibody enhances immune response by selectively targeting Tregs

A new research paper was published in Volume 16 of Oncotarget on July 9, 2025, titled "A novel anti-human CD25 mAb with preferential reactivity to activated T regulatory cells depletes them from the tumor microenvironment."

17 Jul 2025

Study provides a molecular snapshot of Tanshi constitution's immunological landscape

The study aims to uncover the immunological basis of Tanshi (phlegm-dampness) constitution—a subhealth type in traditional Chinese medicine (TCM)—using single-cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs).

7 Jul 2025

Study explores how a familiar spice tackles the toughest cancer cells

Researchers found that clinically achievable doses of curcumin, the active compound in turmeric, target and suppress colorectal cancer stem-like cells, especially in early adenomas. Curcumin shifts these cells toward differentiation, delays tumor growth in mice, and may offer a safe preventive strategy.

27 Jun 2025

Scaling B-cell cloning workflows for antibody development

Explore the latest tools that boost speed and accuracy in B-cell cloning processes.

From Cellenion 24 Jun 2025

BioSkryb Genomics and Tecan introduce a single-cell multiomics workflow for sequencing-ready libraries in under ten hours

BioSkryb Genomics and Tecan Group, today introduced a high-throughput single-cell workflow, combining BioSkryb's 384-well format of the ResolveOME™ Whole Genome and Transcriptome Single-Cell Core Kit with the Uno Single Cell Dispenser™, provided by Tecan.

26 Apr 2025

Multiple myeloma care improved using innovative optical genome mapping

Researchers have demonstrated the potential of the innovative optical genome mapping (OGM) technique for the diagnosis, prognosis, and therapeutic management of multiple myeloma.

15 Apr 2025

Research findings solve the paradox of how the immune system balances speed and precision

Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted to keep different pathogens in check.

19 Mar 2025

Innovative AI-enabled, low-cost device makes flow cytometry accessible for clinical use

A team of researchers at the George R. Brown School of Engineering and Computing at Rice University has developed an innovative artificial intelligence (AI)-enabled, low-cost device that will make flow cytometry ⎯ a technique used to analyze cells or particles in a fluid using a laser beam ⎯ affordable and accessible.

2 Mar 2025

Zika virus hijacks tunneling mechanism to infect placental cells

Infection with Zika virus in pregnancy can lead to neurological disorders, fetal abnormalities and fetal death. Until now, how the virus manages to cross the placenta, which nurtures the developing fetus and forms a strong barrier against microbes and chemicals that could harm the fetus, has not been clear.

22 Feb 2025

Do prenatal antibiotics weaken breast milk immunity? A new study aims to find out

A new study will investigate whether prenatal antibiotic use impairs breast milk immune function and disrupts neonatal gut microbiota, potentially affecting infant health. Researchers aim to assess how prolonged antibiotic exposure in late pregnancy alters breast milk IgA and neonatal immune development.

19 Feb 2025

Study reveals sex-specific differences in microglial response to CSF1R inhibition

Researchers investigate the sex-dependent microglial response to a colony-stimulating factor 1 receptor (CSF1R) inhibitor.

24 Jan 2025

How stress fuels allergic skin inflammation

Researchers investigate the cellular and molecular mechanisms through which stress exacerbates immunoglobulin E cutaneous allergic inflammation.

9 Jan 2025

Scientists uncover how aging rewires the brain's molecular landscape

Scientists mapped how aging alters gene expression across brain cell types in mice, revealing immune activation, neuronal decline, and hypothalamus-specific changes that may impact aging and neurodegeneration.

2 Jan 2025

Golgi apparatus plays crucial role in enhancing T-cell function against cancer

The Golgi apparatus modifies, sorts and packages proteins to be sent to their final destinations, whether that's within or outside of the cell.

23 Nov 2024

Transposable elements found to be dysregulated in Alzheimer's brains, revealing potential targets for therapy

Study reveals widespread dysregulation of transposable elements (TEs) in aging human brains with Alzheimer's disease, using advanced techniques like CRISPR interference to identify TE-related risk genes.

9 Oct 2024

Study reveals how morphogens and cell adhesion create sharp tissue boundaries

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, demonstrate how morphogens combined with cell adhesion can generate tissue domains with a sharp boundary in an in vitro model system.

8 Oct 2024

Discovery of antibodies that boost complement activation against K. pneumoniae

Researchers investigate antibody-dependent complement activation during Klebsiella pneumoniae infection.

30 Sep 2024

Dietary antigens reduce small intestine cancer by boosting immune T-cells

Study shows that dietary antigens can suppress small intestine carcinogenesis by activating T-cells through Peyer's patches. Adding bovine serum albumin (BSA) or ovalbumin (OVA) to antigen-free diets restored immune function and reduced tumor growth in mice.

22 Sep 2024

Scientists reveal how DNA methylation drives astrocytes to become stem cells, unlocking new potential for brain repair

Researchers have discovered that DNA methylation is crucial for reprogramming astrocytes into stem cells in the adult mouse brain, especially after ischemic injury, with potential implications for regenerative medicine.

6 Sep 2024

Active immune cells discovered in brain's cranial bone marrow fighting glioblastomas

A study uncovers the presence and activity of immune cells in glioblastoma, revealing new insights into brain tumor immunology and potential treatment avenues.

4 Aug 2024