Human Leukocyte Antigen News and Research

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Topical immunotherapy clears precancerous skin lesions and reduces cancer risk

Calcipotriol-plus–5-FU therapy activates immune pathways, offering long-lasting protection against squamous cell carcinoma by targeting precancerous lesions.

6 Jan 2025

A scaffolded vaccine approach for broader influenza protection

Most people who get the seasonal influenza vaccine – which contains strains of viruses from distinct virus subtypes – mount a strong immune response to one strain, leaving them vulnerable to infection by the others, and researchers have long wondered what impacts such variable responses more – host genetics or prior exposure to virus strains.

19 Dec 2024

Exploring the potential of MSCs in cancer therapy

A new review was published in Oncotarget's Volume 15 on November 22, 2024, entitled "Mesenchymal stem cells – the secret agents of cancer immunotherapy: Promises, challenges, and surprising twists."

4 Dec 2024

Neoantigen DNA vaccines improve survival and immunity in triple-negative breast cancer patients

A new phase 1 trial demonstrates the safety and effectiveness of personalized neoantigen DNA vaccines, showing promising immune responses and improved recurrence-free survival in high-risk triple-negative breast cancer patients.

17 Nov 2024

Stem-cell implants restore vision in patients with corneal stem cell deficiency

Researchers successfully tested the safety and preliminary efficacy of stem-cell-derived corneal implants, showing promise for restoring vision in patients with severe corneal damage.

12 Nov 2024

Genetic and environmental drivers shape early type 1 diabetes risk in children

Researchers from the TEDDY study highlight how specific genetic and environmental factors may drive early autoimmunity linked to type 1 diabetes in children, emphasizing distinct patterns for different autoantibodies.

5 Nov 2024

Genetic variant identified as potential predictor for severe ulcerative colitis

The HLA-DRB1*01:03 genetic variant is associated with severe ulcerative colitis, significantly raising the risk of major surgeries and hospitalizations.

21 Oct 2024

Genetic risk factors for long-COVID uncovered in a large multi-ethnic study

Researchers identified genetic loci and phenotypes linked to long-COVID in the largest multi-ethnic GWAS, revealing increased risk factors for chronic conditions like fatigue, depression, and fibromyalgia.

16 Oct 2024

Cardiovascular disease pathways associated with psoriasis, but not other immune-mediated diseases

A genetic connection between cardiovascular disease and psoriasis highlights shared inflammatory pathways, emphasizing the need for cardiovascular monitoring.

19 Sep 2024

Long COVID patients maintain robust immune memory two years after infection

Researchers discovered that SARS-CoV-2-specific T and B cells in long COVID patients are maintained for two years, similar to fully recovered individuals, offering insights into long-term immunity.

17 Sep 2024

New insights into stiff-person syndrome, advancing diagnosis and treatment

Research explores the complexities of diagnosing and treating stiff-person syndrome, emphasizing the uncertain role of GAD antibodies and the promise of novel therapies.

5 Sep 2024

Long-term immune changes persist in unvaccinated COVID-19 patients

Study reveals that unvaccinated individuals experience significant long-term changes in immune parameters up to ten months post-COVID-19 infection, with a shift towards a Th2 cytokine profile.

21 Jul 2024

Novel Co-STAR cells show promise in targeting and eradicating cancer

Using genetic engineering techniques, investigators at the Johns Hopkins Kimmel Cancer Center and its Ludwig Center, the Lustgarten Laboratory and Bloomberg~Kimmel Institute for Cancer Immunotherapy have designed a novel type of cell to recognize and fight cancer.

11 Jul 2024