Periodontitis News and Research

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Copper metabolism identified as a new therapeutic target for inflammatory osteolysis

Inflammatory osteolysis is a condition involving progressive bone tissue destruction and is observed in many well-known skeletal disorders, including rheumatoid arthritis, osteoporosis, and chronic apical periodontitis.

5 Mar 2026

Periodontal bacteria trigger bone density reduction via the gut

Periodontitis, a chronic inflammatory disease of the gums, affects hundreds of millions of people worldwide and is increasingly linked to systemic disorders beyond the oral cavity.

4 Mar 2026

Childhood cavities and gum disease raise adult heart disease risk

The link between childhood oral health and adult heart disease underscores the need for preventive dental care to enhance lifelong cardiovascular health.

4 Mar 2026

Poor oral health in childhood linked to higher incidence of cardiovascular disease in adulthood

A tooth cavity and bleeding gums is a common scenario among Danish children – and one that researchers now connect to health problems long after the last baby tooth has left the mouth.

2 Mar 2026

Clear aligners protect oral microbiome better than fixed braces

Researchers compare the effects of clear aligners and fixed appliances on oral microbiota and oxidative stress in the oral cavity.

4 Feb 2026

Researchers identify possible target for new therapies against periodontitis aggravated by smoking

Smoking tobacco is known to worsen symptoms of periodontitis and reduce responsiveness to treatment. Using high-resolution spatial transcriptomics, researchers identified differences between smokers and non-smokers in the expression of genes that weaken gum epithelial integrity and cause bone damage through inflammation.

12 Jan 2026

Sugarcane protein mouthwash helps protect oral health during head and neck cancer treatment

An artificial saliva in the form of a mouthwash, produced with the CANECPI-5 protein extracted from sugarcane and modified in a laboratory, can aid in treating teeth in patients with head and neck cancer. In these cases, radiotherapy very close to the mouth can destroy salivary glands and compromise saliva production, which is essential for controlling bacteria and disease.

7 Jan 2026

Periodontal bacterial load associated with disease severity in multiple sclerosis

Increasing evidence suggests that the severe gum disease, periodontitis, may contribute to central nervous system disorders through chronic inflammation.

30 Dec 2025

New data supports link between gum disease and heart disease

There is increasing evidence that gum disease is associated with increased risk of cardiovascular events, including heart attack, stroke, atrial fibrillation, heart failure and cardiometabolic health conditions. Effective prevention and treatment of gum disease, also called periodontal disease, could potentially decrease the burden of cardiovascular disease, according to a new scientific statement published today in the American Heart Association's flagship journal Circulation.

16 Dec 2025

Study finds link between Pg-induced periapical disease and systemic metabolic dysfunction

New study examines the oral pathogen Porphyromonas gingivalis (Pg) and suggests its influence may extend beyond dental tissues.

3 Dec 2025

Evidence links severe gum disease to erectile dysfunction and broader men’s health risks

A healthy mouth is also key to a healthy body, as gum disease has been linked to non-communicable diseases such as diabetes, cardiovascular disease, rheumatoid arthritis and Alzheimer's.

20 Nov 2025

Successful root canal treatment benefits metabolic and heart health

Successful root canal treatment could reduce inflammation linked to heart disease and improve levels of blood sugar and cholesterol.

18 Nov 2025

New insights into periodontitis reveal gender-specific inflammatory mechanisms

A study out of the University of North Carolina at Chapel Hill has unveiled new insights into the inflammatory processes behind periodontitis, a common and debilitating gum disease. Research conducted by UNC Adams School of Dentistry's Julie Marchesan, DDS, PhD, and UNC School of Medicine's Jenny Y. Ting, PhD, found that a part of the immune system called the inflammasome plays a key role in disease development, and that blocking this system prevents bone resorption only in males.

14 Nov 2025

Ozone exposure weakens lung function and reshapes the oral microbiome

Ozone exposure reshapes the oral microbiome and reduces lung function, particularly in men, revealing significant health risks associated with pollution.

1 Oct 2025

Mediterranean diet may protect gums by reducing severe periodontitis

This study reveals that the Mediterranean diet may protect against periodontitis, highlighting its benefits for oral health and inflammation reduction.

18 Sep 2025

Mediterranean diet linked to better gum health

People living in the UK and following a diet close to the Mediterranean diet are more likely to have better gum health, with potentially lower amounts of gum disease and inflammation.

15 Sep 2025

Gut bacteria and insomnia influence each other in small but significant ways, study shows

Scientists used Mendelian randomisation to explore the two-way relationship between gut microbiota and insomnia, analyzing GWAS data from over 386,000 individuals and two major microbiome cohorts. The study found only limited taxa surviving strict correction, suggesting small but causal links that highlight the gut–brain axis in sleep health.

21 Aug 2025

Mouth and gut microbes talk to each other - here’s why it matters for disease

Researchers reviewed nearly 250 studies to uncover how the oral and gut microbiomes communicate through multiple pathways, influencing the risk of diseases such as IBD, colorectal cancer, and cardiovascular disorders. The review highlights that maintaining oral health and dietary habits is crucial for overall systemic wellbeing.

4 Aug 2025

Oleic acid from olive oil reduces infection-related bone loss with age

A mouse study shows that dietary oleic acid, a key Mediterranean diet component, protects against age-related bone and microbiome damage triggered by periodontal infection. In contrast, a Western-style palmitic acid diet worsens bone loss and destabilizes the gut microbiome.

30 Jun 2025

Exercise and omega-3 reduce oral inflammation in animal study

A study published in the journal Scientific Reports indicates that physical exercise combined with omega-3 supplementation considerably improves the immune response and reduces the severity of chronic apical periodontitis.

11 Jun 2025