Rapamycin News and Research

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Rapamycin is a drug used to prevent the rejection of organ and bone marrow transplants by the body. Rapamycin is an antibiotic that blocks a protein involved in cell division and inhibits the growth and function of certain T cells of the immune system involved in the body's rejection of foreign tissues and organs. It is a type of immunosuppressant and a type of serine/threonine kinase inhibitor. Rapamycin is now called sirolimus.

New mouse model reveals primary trigger of rare muscle disorder

Myofibrillar myopathy type 6 (MFM6) is a rare genetic muscle disorder that leads to severe muscle weakness and a drastically shortened life expectancy due to a disruption in muscle protein regulation.

24 Apr 2026

Lower-protein toddler formula does not reduce BMI at age 2, trial finds

A large randomized trial in Germany and Spain found that lowering milk protein intake during the second year of life did not reduce BMI z-score at 24 months, though it did produce a temporary BMI reduction at 18 months. Lower protein intake also led to more stable weight and length trajectories, while higher protein intake pushed growth upward relative to WHO standards.

15 Apr 2026

Mayo Clinic researchers develop experimental nanotherapy to treat aggressive brain tumors

Mayo Clinic researchers developed an experimental nanotherapy that delivers two cancer drugs directly to brain tumors, according to a study published in Communications Medicine.

6 Apr 2026

UT San Antonio study evaluates rapamycin’s potential to promote healthy aging

UT Health San Antonio, the academic health center of The University of Texas at San Antonio (UT San Antonio) is launching a multi-phase clinical study to better understand how the drug rapamycin may promote healthy aging.

25 Mar 2026

How somatic mutations shape disease and reveal new drug targets

Researchers reviewed how somatic mutations accumulate in normal and diseased tissues, showing that natural selection can expand clones that influence disease risk, tissue adaptation, or cellular resilience. The study proposes somatic genomics as a powerful strategy to uncover disease mechanisms and identify new therapeutic targets across multiple conditions.

8 Mar 2026

Repurposed kidney drug finerenone shows promise in treating premature ovarian insufficiency

Premature ovarian insufficiency (POI) is a clinically significant cause of infertility that affects between 1 to 3% of women of childbearing age.

5 Mar 2026

Barshop Institute at UT Health San Antonio secures major federal funding for longevity trial

Positioning The University of Texas at San Antonio as a national anchor for aging and longevity science, its Sam and Ann Barshop Institute for Longevity and Aging Studies will receive up to $38 million in federal funding for the first nationwide clinical study in healthy longevity.

24 Feb 2026

ARPA-H-funded PROSPR program focuses on the biological hallmarks of aging

Columbia University Mailman School of Public Health has received an award as part of the PROactive Solutions for Prolonging Resilience (PROSPR) program within the Advanced Research Projects Agency for Health (ARPA-H) to accelerate research on the biological hallmarks of aging.

24 Feb 2026

Longevity treatments extend life but affect variation in age-at-death

A key goal in aging research is not just to extend life, but to ensure more people live longer and healthier lives with less variation in age-at-death; a concept known as "squaring the survival curve."

24 Feb 2026

Milken Institute and Ann Theodore Foundation fund mTOR inhibitor trial for sarcoidosis

The Milken Institute Science Philanthropy Accelerator for Research and Collaboration (SPARC), in partnership with the Ann Theodore Foundation (ATF), has launched a new funding program to support a future clinical trial in cutaneous sarcoidosis.

20 Feb 2026

Distinct gut toxicity patterns emerge with targeted cancer treatments

A new paper was published in Volume 13 of Oncoscience on February 6, 2026, titled "Gastrointestinal toxicity of targeted cancer therapies in the United States: Clinicopathologic patterns, FDA safety frameworks, and implications for national patient protection."

20 Feb 2026

Case report examines potential cancer risks after mRNA vaccination

A new case report was published in Volume 17 of Oncotarget on February 6, 2026, titled "Exploring the potential link between mRNA COVID-19 vaccinations and cancer: A case report with a review of haematopoietic malignancies with insights into pathogenic mechanisms."

12 Feb 2026

ICSA 2025: Infection's role in cellular senescence, inflammation, and aging

A new meeting report was published in Volume 17, Issue 12 of Aging-US on December 23, 2025, titled "Cellular senescence meets infection: highlights from the 10th annual International Cell Senescence Association (ICSA) conference, Rome 2025."

8 Jan 2026

Engineered extracellular vesicles enable antigen-specific regulatory T cell induction

A research team at the Nano Life Science Institute (WPI-NanoLSI) and the Faculty of Medicine at Kanazawa University has developed a new class of engineered extracellular vesicles (EVs) capable of inducing antigen-specific regulatory T cells (Tregs), the immune cells that play a central role in suppressing excessive immune responses.

22 Dec 2025

Ultra-processed foods linked to higher mortality in Black women with breast cancer

A study from Rutgers Cancer Institute researchers in eClinicalMedicine is the first to link ultra-processed foods to reduced survival in Black women with breast cancer.

18 Dec 2025

Scientists outline how organ rejuvenation strategies could solve the donor shortage

Researchers outline why organs from older donors are often discarded and identify the biological and immunological pathways that make them vulnerable to injury. They also highlight emerging rejuvenation technologies including machine perfusion, senotherapeutics, and regenerative strategies that could safely expand the donor pool.

11 Dec 2025

Sterilized fermented beverage targets obesity and type 2 diabetes pathways in computational study

Researchers profiled a terminally sterilized probiotic-fermented MFH beverage and identified aporphine alkaloids and flavonoids with favorable predicted ADMET properties. Integrated network pharmacology, molecular docking, and 100-ns MD simulations suggest multi-target engagement of metabolic-inflammatory pathways relevant to obesity and type 2 diabetes.

9 Dec 2025

Early exposure to fat-related food smells increases lifelong obesity risk

Early exposure to fat-related food odors during development alters central sensory processing and metabolic regulation, independently of maternal obesity or nutrient intake. These sensory cues program long-term susceptibility to obesity, impaired thermogenesis, and altered brain responses to dietary fat in adulthood.

7 Dec 2025

New analysis reveals fundamental flaws in widely used measures of biological aging

A landmark review published today in Genomic Psychiatry challenges researchers to fundamentally reconsider how the field measures and conceptualizes biological aging.

3 Dec 2025

Study finds GLP-1 drugs improve strength and reverse aging biology in mice

Researchers showed that GLP-1 receptor agonism counteracts aging across multiple organs in mice, improving strength and reversing molecular aging signatures without meaningful effects on body weight. These benefits depended largely on hypothalamic GLP-1R signaling and closely mirrored the anti-aging patterns produced by rapamycin.

23 Nov 2025

Rapamycin News and Research

New mouse model reveals primary trigger of rare muscle disorder

Lower-protein toddler formula does not reduce BMI at age 2, trial finds

Mayo Clinic researchers develop experimental nanotherapy to treat aggressive brain tumors

UT San Antonio study evaluates rapamycin’s potential to promote healthy aging

How somatic mutations shape disease and reveal new drug targets

Repurposed kidney drug finerenone shows promise in treating premature ovarian insufficiency

Barshop Institute at UT Health San Antonio secures major federal funding for longevity trial

ARPA-H-funded PROSPR program focuses on the biological hallmarks of aging

Longevity treatments extend life but affect variation in age-at-death

Milken Institute and Ann Theodore Foundation fund mTOR inhibitor trial for sarcoidosis

Distinct gut toxicity patterns emerge with targeted cancer treatments

Case report examines potential cancer risks after mRNA vaccination

ICSA 2025: Infection's role in cellular senescence, inflammation, and aging

Engineered extracellular vesicles enable antigen-specific regulatory T cell induction

Ultra-processed foods linked to higher mortality in Black women with breast cancer

Scientists outline how organ rejuvenation strategies could solve the donor shortage

Sterilized fermented beverage targets obesity and type 2 diabetes pathways in computational study

Early exposure to fat-related food smells increases lifelong obesity risk

New analysis reveals fundamental flaws in widely used measures of biological aging

Study finds GLP-1 drugs improve strength and reverse aging biology in mice

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