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Chemotherapy may trigger inflammatory response that fuels bladder cancer resistance

Chemotherapy used to target and kill bladder cancer cells may trigger an inflammatory response that ultimately may make the cancer more resistant to treatment, according to new research from scientists at Houston Methodist.

16 Jul 2025

Osaka researchers develop drug to prevent stroke-induced neuronal death

Stroke is said to be the second leading cause of death worldwide after heart disease. To prevent the death of neurons in the brain, a research group led by Osaka Metropolitan University Associate Professor Hidemitsu Nakajima of the Graduate School of Veterinary Science has developed a drug that inhibits a protein involved in cell death.

15 Jul 2025

Light-activated drug discovery identifies broad-spectrum antivirals

UC Santa Barbara researchers and collaborators from campus biotech spinoff Integrated Biosciences, as well as Harvard, MIT and genomics company Illumina Ventures are using optogenetics - the use of light to probe the functions of living tissue - to find compounds to help our bodies more effectively help themselves in times of physiological stress.

15 Jul 2025

Real-time protein misfolding detection by MiROM for cancer treatment monitoring

MiROM identifies proteins by using mid-infrared light to detect molecular vibrations – essentially the natural "dance" of molecules within protein structures. Unlike optical spectroscopy, which measures light attenuation, optoacoustics capture ultrasound waves generated when proteins absorb infrared light.

15 Jul 2025

New nanobody-liposome combo stops lung cancer growth and delivers targeted chemotherapy

Researchers engineered a nanobody-conjugated liposome (A5-LNP-DOX) that targets CD155 and delivers doxorubicin directly to lung adenocarcinoma cells, dramatically suppressing tumor growth in preclinical models. This approach not only inhibited cancer cell migration and invasion but also showed strong potential for safer, more precise lung cancer therapy.

14 Jul 2025

Prostate cancer cells evade ferroptosis by accumulating lipid droplets

A new research paper was published in Volume 16 of Oncotarget on June 25, 2025, titled "Hypoxia induced lipid droplet accumulation promotes resistance to ferroptosis in prostate cancer."

14 Jul 2025

Insecticide exposure could impair mental function in older adults

The study investigates the link between pesticide exposure and cognitive impairment in older adults, suggesting a need for improved prevention strategies.

11 Jul 2025

Hydrogels could be key to safer, smarter cancer drug delivery

Hydrogels could revolutionize cancer treatment by facilitating targeted drug delivery, reducing adverse effects, and enhancing therapeutic effectiveness.

11 Jul 2025

How hydrogels are shaping the future of targeted cancer drug delivery

A large-scale bibliometric analysis maps global research on hydrogels as next-generation drug delivery systems for cancer therapy. The study highlights emerging trends, key contributors, and future directions to advance precision medicine in oncology.

10 Jul 2025

Mapping vulnerability or resilience in Alzheimer's through imaging and genetics

It's been recognized for some time that Alzheimer's disease affects brain regions differently and that tau - a protein known to misbehave - plays an important role in the disease.

9 Jul 2025

Landmark discovery reshapes understanding of key cancer protein MCL-1

Landmark research on MCL-1, a critical protein that is an attractive target for cancer drug development, helps explain why some promising cancer treatments are causing serious side effects, and offers a roadmap for designing safer, more targeted therapies.

8 Jul 2025

Retinal cells rewire to preserve vision in retinitis pigmentosa

Scientists at the Jules Stein Eye Institute at the David Geffen School of Medicine at UCLA have discovered that certain retinal cells can rewire themselves when vision begins to deteriorate in retinitis pigmentosa, a genetic eye disease that leads to progressive blindness.

7 Jul 2025

Mitochondria depletion in stem cells offers insights into cellular energy and evolution

By using a genetic technique developed at UT Southwestern Medical Center that forces cells to rid themselves of mitochondria, researchers are gaining new insights into the function of these critical organelles.

7 Jul 2025

Evolutionary mutation weakens human immune response to solid tumors

New research from UC Davis Comprehensive Cancer Center has uncovered an evolutionary change that may explain why certain immune cells in humans are less effective at fighting solid tumors compared to non-human primates.

3 Jul 2025

Experimental medication sensitizes glioblastoma to treatment and blocks tumor spread

A potential treatment for glioblastoma crafted by scientists at The Wertheim UF Scripps Institute renders the deadly brain cancer newly sensitive to both radiation and chemotherapy drugs, and blocks the cancer's ability to invade other tissue, a new study shows.

2 Jul 2025

Do spicy foods help or hurt your gut health?

Capsaicin, the spicy compound in chili peppers, not only influences inflammation, metabolism, and cancer risk but also shapes the gut microbiome in complex, context-dependent ways. This comprehensive review highlights both the therapeutic promise and potential risks of capsaicin, calling for deeper research into its microbiome-mediated effects.

26 Jun 2025

New insights into programmed cell death could offer relief for inflammatory bowel disease

New basic science insights into programmed cell death could offer relief for inflammatory bowel disease.

26 Jun 2025

Brown University scientists discover protein essential for heart survival

New findings by a team of molecular biologists at Brown University on the critical role of a protein called AIMP3 in heart function could inform new treatments for heart disease.

25 Jun 2025

Fusion genes found to be pivotal players in cancer development

Fusion genes, arising from abnormal chromosomal rearrangements, are gaining recognition as pivotal players in cancer development. These genetic alterations result in the creation of hybrid genes with altered functions, often driving tumor progression.

25 Jun 2025

Researchers link brain waste clearance to early Alzheimer’s damage

A crucial link between the brain's cleaning system and deterioration of neurons associated with Alzheimer's disease has been discovered by University of Queensland researchers.

25 Jun 2025