Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

AI serves as a tool to fight drug resistance and accelerate new antibiotic development

Researchers at McMaster University and the Massachusetts Institute of Technology (MIT) have made two scientific breakthroughs at once: they not only discovered a brand-new antibiotic that targets inflammatory bowel diseases (IBD), but also successfully used a new type of AI to predict exactly how the drug works. To their knowledge, this a global first for the AI.

3 Oct 2025

Stem cells and organoids offer a new understanding of APOL1 kidney disease

Chronic kidney disease (CKD) affects more than 700 million people worldwide and is caused by genetic and environmental factors, as well as existing medical conditions. Known genetic risk factors for CKD include mutations in a gene called APOL1.

3 Oct 2025

How the University of Manchester used Bruker equipment to map the dynamics of complex protein

Discover how Bruker and the University of Manchester joined forces to discover more on the dynamics of complex protein.

From Bruker BioSpin Division 2 Oct 2025

New data analysis method accelerates design of safer covalent inhibitors

Researchers at Baylor College of Medicine have developed a powerful new data analysis method named COOKIE-Pro (Covalent Occupancy Kinetic Enrichment via Proteomics) that provides a comprehensive, unbiased view of how a class of drugs, called covalent inhibitors, interacts with proteins throughout the cell.

30 Sep 2025

New evidence shows blood-brain barrier remains intact in Alzheimer's mouse model

A team of scientists at Texas Tech University Health Sciences Center (TTUHSC) has published new evidence suggesting that the brain's protective shield - known as the blood-brain barrier (BBB) - remains largely intact in a commonly used mouse model of Alzheimer's disease.

29 Sep 2025

Concept Life Sciences expands integrated drug discovery facilities

Concept Life Sciences, a leading contract research organisation (CRO) serving the global life sciences and pharma industry, today announces the official opening, by Jonathan Pearce, the Labor Member of Parliament for High Peak, of its expanded integrated drug discovery facilities at its Chapel-en-le-Frith site.

From Concept Life Sciences 29 Sep 2025

Advanced workflow automation and scalable image analysis in spatial biology

ZEISS Microscopy and Concept Life Sciences, a UK-based contract research organization (CRO), announced their collaboration aimed at pioneering new approaches to workflow automation and scalable image analysis in spatial biology.

From Concept Life Sciences 26 Sep 2025

Targeting TGF-β signaling as a strategy to treat liver fibrosis

Liver fibrosis, a pathological scarring process resulting from chronic liver injury, represents a significant global health burden due to its potential progression to cirrhosis and hepatocellular carcinoma.

25 Sep 2025

AI-guided platform improves design and efficiency of therapeutic nanoparticles

Biomedical engineers at Duke University have developed a platform that combines automated wet lab techniques with artificial intelligence (AI) to design nanoparticles for drug delivery.

24 Sep 2025

Blocking iron-regulating enzyme triggers cancer cell death in multiple myeloma

Researchers at Duke University have shown that blocking an enzyme involved in iron regulation not only kills multiple myeloma cancer cells, but also increases the effectiveness of current therapies against the disease.

24 Sep 2025

Scientists show for the first time how fibroblasts go 'rogue' in different diseases

Scientists have mapped underappreciated scaffolding cells in skin, known as fibroblasts. They show for the first time how fibroblasts go 'rogue' in many different diseases affecting multiple organs – from acne and psoriasis, to rheumatoid arthritis and inflammatory bowel disease.

24 Sep 2025

Groundbreaking discovery could transform leishmaniasis treatment

Leishmaniasis, a neglected tropical disease prevalent across 90 countries, affects approximately 12 million people worldwide, with 350 million more at risk of infection.

24 Sep 2025

New class of antibiotics shows potent activity against multidrug-resistant bacteria

Scientists at the University of Liverpool, working with international collaborators, have discovered Novltex, a groundbreaking new class of antibiotics with potent activity against some of the world's most dangerous multidrug-resistant (MDR) bacteria.

18 Sep 2025

Advancing drug discovery with AI, generative chemistry, and 3D molecular design

Discover how AI, generative chemistry, and 3D molecular design are revolutionizing drug discovery.

From Optibrium Ltd. 18 Sep 2025

Enhanced Genomics extends Series A funding to USD $19 million to drive development of therapeutics pipeline

Enhanced Genomics ('Enhanced'), the biotechnology company pioneering 3D multi-omics to rapidly identify high-confidence, genetically validated drug targets for common diseases, today announced it has completed a financing round, extending its total Series A funding to $19 million.

17 Sep 2025

AI breakthrough offers a new way to predict and visualize disease processes

To solve a problem, we have to see it clearly. Whether it's an infection by a novel virus or memory-stealing plaques forming in the brains of Alzheimer's patients, visualizing disease processes in the body is the first step toward alleviating human suffering. It's also often the most difficult and costly.

16 Sep 2025

Mathematical model recreates swallowing and reveals causes of dysphagia

For most people, swallowing is second nature, but how does it occur, and why do some people have difficulty with it? Researchers at Kyushu University in Japan have started to tackle these questions by developing a mathematical model that recreates the muscle movements of the esophagus that occur during swallowing.

16 Sep 2025

Inside the lab of the future: Automation, NMR, and the power of integration

Discover how Bruker is changing the future of labs and NMR through its R&D efforts.

From Bruker BioSpin Division 16 Sep 2025

Study identifies thalamic pathway that reinforces alcohol seeking in withdrawal

What compels someone to keep engaging in alcohol use, even if it damages their health, relationships and wellbeing? A new study from Scripps Research offers an important clue: a small midline brain region plays a key role in how animals learn to continue drinking to avoid the stress and misery of withdrawal.

13 Sep 2025

Rice University team develops tool to track protein aggregation hot spots

A novel strategy developed at Rice University allows scientists to zoom in on tiny segments of proteins inside living cells, revealing localized environmental changes that could indicate the earliest stages of diseases such as Alzheimer's, Parkinson's and cancer.

13 Sep 2025