Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Protein MIIP suppresses colorectal cancer by regulating immune cell signaling

Colorectal cancer remains one of the leading causes of cancer-related mortality worldwide, largely due to metastasis and limited responses to immunotherapy in most patients.

16 Mar 2026

Researchers identify cellular drivers of gut scarring in Crohn’s disease

As inflamed regions of the gut form scar tissue, the space within the gut lumen becomes smaller and more restricted, leading to symptoms of gut obstruction.

16 Mar 2026

New AI system reduces pathologist workload while maintaining diagnostic accuracy

Artificial intelligence could make cancer diagnosis safer and fairer by learning when to defer to human pathologists without overloading them, according to researchers from the University of Surrey and Monash University.

13 Mar 2026

Blood protein structure changes may enable earlier detection of Alzheimer’s

Advanced proteomics and AI reveal blood protein changes, offering insights into early Alzheimer's detection and differentiation from mild cognitive impairment.

13 Mar 2026

New study identifies specific brain cells most vulnerable to ALS and dementia

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) belong to a spectrum of neurodegenerative diseases with overlapping symptoms, characterized by muscle wasting, paralysis, dementia, and other serious impairments.

12 Mar 2026

Blood test marker p-tau217 helps detect early dementia risk in cognitively healthy older women

A long-term study of 2,766 women in the Women’s Health Initiative Memory Study found that higher baseline plasma p-tau217 levels were associated with a greater risk of developing mild cognitive impairment or probable dementia.

11 Mar 2026

Review explores how generative AI could support precision oncology decision-making

A narrative review examines how generative AI tools such as large language models and vision-language models could assist precision oncology by interpreting genomic data, matching patients to clinical trials, and synthesizing complex clinical information. The authors emphasize governance, human oversight, and retrieval-based safeguards to ensure these systems are deployed safely in cancer care.

11 Mar 2026

How the aging gastrointestinal tract drives age-related cognitive decline

We become forgetful as we age. This is often seen as a universal truth, but in fact it is far from universal: some people remain incredibly sharp at 100 years old, while others experience memory loss starting in middle age.

11 Mar 2026

Researchers develop DNA aptamer to detect Alzheimer's biomarkers

With aging populations on the rise, the need for better tools to diagnose and monitor Alzheimer's disease (AD), the most common cause of dementia, has never been more urgent.

10 Mar 2026

New peptide fragments teach the gut to tolerate food

In little moments like when sipping coffee or licking an ice cream cone, it doesn't seem like your body is pulling off a biological miracle. But it is. That cookie is not you-yet when you put it in your mouth, your body is able to tolerate it and process it without any detriment to your health in a process called oral tolerance. How does the human body make that decision between tolerance and rejection?

9 Mar 2026

How somatic mutations shape disease and reveal new drug targets

Researchers reviewed how somatic mutations accumulate in normal and diseased tissues, showing that natural selection can expand clones that influence disease risk, tissue adaptation, or cellular resilience. The study proposes somatic genomics as a powerful strategy to uncover disease mechanisms and identify new therapeutic targets across multiple conditions.

8 Mar 2026

Can one AI analyze all medical scans? MedVersa shows promise across multiple imaging tasks

esearchers developed MedVersa, a generalist multimodal AI model trained on tens of millions of medical imaging instances to perform diverse radiology tasks within a single framework. The model matched or exceeded specialist AI systems across several benchmarks and produced radiology reports comparable to human reports in many cases while improving reporting efficiency.

8 Mar 2026

Case report describes treatment of rare calcified solid pseudopapillary pancreatic tumor

A new case report was published in Volume 13 of Oncoscienceon February 7, 2026, titled "Massive calcified solid pseudopapillary neoplasm of the pancreatic head."

6 Mar 2026

Ketone body can strengthen the fitness and antitumor activity of CAR T cells

A naturally occurring byproduct of liver metabolism–the ketone body, β-hydroxybutyrate (BHB)–can strengthen the fitness and antitumor activity of CAR T cells.

6 Mar 2026

Virtual immunostaining method improves detection of vascular invasion in thyroid cancer

In a groundbreaking study published in BME Frontiers, researchers from the University of California, Los Angeles (UCLA), in collaboration with international partners, have developed a deep learning-based virtual multiplexed immunostaining (mIHC) method.

6 Mar 2026

Machine learning model may provide an earning warning of preeclampsia in late gestation

A machine-learning model developed by Weill Cornell Medicine investigators may provide clinicians with an early warning of a complication that can occur late in pregnancy.

6 Mar 2026

Single dose of CAR-astrocyte therapy halves amyloid levels in mice brains

The new generation of Alzheimer's disease drugs - the first proven to change the course of the disease - typically extend independent living for patients by 10 months.

6 Mar 2026

New compound shows promise in protecting the liver from damage after small bowel surgery

When parts of the small intestine are diseased or die, the treatment can involve surgically removing the affected tissue.

6 Mar 2026

MSK uncovers how interacting mutations shield breast cancer

Researchers at Memorial Sloan Kettering Cancer Center (MSK) have made an important discovery about how genetic mutations in breast cancer patients can interact and drive resistance to certain drugs called CDK4/6 inhibitors. This finding, published in Nature, suggests a new strategy for predicting and preventing resistance to specific therapies based on the tumor's genetic profile.

6 Mar 2026

Researchers propose that Parkinson’s disease may start in the gut, not the brain

A perspective in The Journal of Clinical Investigation argues that environmental exposures may interact with the gut microbiome and intestinal barrier to trigger biological processes linked to Parkinson’s disease. The authors propose that cumulative environmental stressors can erode host resilience, promoting α-synuclein pathology, immune activation, and neurodegeneration.

5 Mar 2026

Pathology News and Research

Further Reading

Protein MIIP suppresses colorectal cancer by regulating immune cell signaling

Researchers identify cellular drivers of gut scarring in Crohn’s disease

New AI system reduces pathologist workload while maintaining diagnostic accuracy

Blood protein structure changes may enable earlier detection of Alzheimer’s

New study identifies specific brain cells most vulnerable to ALS and dementia

Blood test marker p-tau217 helps detect early dementia risk in cognitively healthy older women

Review explores how generative AI could support precision oncology decision-making

How the aging gastrointestinal tract drives age-related cognitive decline

Researchers develop DNA aptamer to detect Alzheimer's biomarkers

New peptide fragments teach the gut to tolerate food

How somatic mutations shape disease and reveal new drug targets

Can one AI analyze all medical scans? MedVersa shows promise across multiple imaging tasks

Case report describes treatment of rare calcified solid pseudopapillary pancreatic tumor

Ketone body can strengthen the fitness and antitumor activity of CAR T cells

Virtual immunostaining method improves detection of vascular invasion in thyroid cancer

Machine learning model may provide an earning warning of preeclampsia in late gestation

Single dose of CAR-astrocyte therapy halves amyloid levels in mice brains

New compound shows promise in protecting the liver from damage after small bowel surgery

MSK uncovers how interacting mutations shield breast cancer

Researchers propose that Parkinson’s disease may start in the gut, not the brain

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