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AI-guided discovery of selective DGKα inhibitors to overcome checkpoint resistance in solid cancers

Insilico Medicine has developed a new class of small molecule inhibitors targeting diacylglycerol kinase alpha (DGKα) designed to restore T cell function and overcome resistance to immune checkpoint blockades in solid cancers.

12 Dec 2025

Mass General Brigham launches AI company to enhance clinical trial matching

Mass General Brigham is announcing the spinout of AIwithCare, a company founded by researchers from the health system who developed an artificial intelligence (AI) screening tool that significantly outperformed manual screening for determining a patient's eligibility and enrolling them in a clinical trial.

12 Dec 2025

Acupuncture improves breast cancer survivors' perceived cognitive impairment

Real and sham acupuncture were more effective at improving breast cancer survivors' perceived cognitive impairment compared with usual care, while real acupuncture was superior to sham acupuncture in improving objective cognitive function, according to results from the randomized ENHANCE phase II clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

12 Dec 2025

Mobile health intervention improves quality of life for adolescent and young adult breast cancer survivors

A mobile health (mHealth) intervention for adolescent and young adult breast cancer survivors that offered tailored support by monitoring electronic patient-reported outcomes (ePROs) significantly improved quality of life and symptoms related to vaginal and arm problems, according to results from a randomized clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

12 Dec 2025

Researchers identify chromatin accessibility changes driving stem cell transformation in MDS

Over the past few decades, advances in hematology have illuminated how a delicate balance between stem cell self-renewal and differentiation sustains healthy blood formation.

12 Dec 2025

Most clinical trials fail to reflect America’s racial and ethnic diversity

A new study finds just 6% of clinical trials used to approve new drugs in the U.S. reflect the country's racial and ethnic makeup, with an increasing trend of trials underrepresenting Black and Hispanic individuals.

12 Dec 2025

Plant-based diets support healthy growth when properly planned for children

Vegetarian and vegan diets can support healthy growth when carefully planned with appropriate supplementation, finds a major new meta-analysis – the most comprehensive study to-date of plant-based diets in children.

12 Dec 2025

Increased epicardial fat volume linked to greater myocardial injury after infarction

Increased volume of epicardial adipose tissue, detected by cardiovascular imaging, was found to be associated with greater myocardial injury after a myocardial infarction.

12 Dec 2025

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Learn how digital connectivity and the PathoVerse are improving pathology workflows and accelerating access to expert diagnostics.

From PathPresenter 12 Dec 2025

Advance care planning improves with automated patient outreach strategies

A strategy for advance care planning (ACP) that included automated outreach from staff who contacted patients to offer assistance significantly boosted the number of patients who completed documentation outlining their wishes in times of serious illness, new research finds.

11 Dec 2025

Smoke from Canadian wildfires linked to worse asthma symptoms in children

New research from the University of Vermont reveals exposure to smoke from Canadian wildfires in the summer of 2023 led to worsening asthma symptoms in children in Vermont and upstate New York.

11 Dec 2025

Breast arterial calcification on mammograms predicts future heart risk

Routine mammograms are a critical tool for breast cancer screening. However, they may also hold crucial, potentially untapped information about a person's risk for cardiovascular disease, the number one cause of death among adults.

11 Dec 2025

New blood biomarker predicts brain damage after cardiac arrest

A blood biomarker yet to be used in cardiac arrest care can give a clearer picture of the extent of brain damage after a cardiac arrest.

11 Dec 2025

Study finds dramatic increase in ADHD medication use

Annual prescriptions for drugs to treat attention-deficit/hyperactivity disorder (ADHD) increased 157 percent in Ontario from 2015 to 2023, according to a new study from researchers at ICES, North York General, and The Hospital for Sick Children (SickKids).

11 Dec 2025

Study offers insight into how coffee and tea intake may influence bone health in older women

A new study from Flinders University offers insight into how two of the world's most popular beverages, coffee and tea, may influence bone health in older women.

11 Dec 2025

Review highlights emerging role of tumor MHC-II in shaping cancer immunotherapy outcomes

Cancer immunotherapy has transformed cancer treatment, yet many patients experience limited or short-lived responses due to immune evasion, tumor heterogeneity, and immune-related adverse events.

11 Dec 2025

Study reveals how Ebola and Marburg viruses damage the human gut

Ebola (EBOV) and Marburg virus (MARV) are highly lethal viruses that cause severe disease in infected patients by extensively damaging the body.

11 Dec 2025

Cleveland Clinic reports promising results for breast cancer vaccine from final Phase 1 data

Cleveland Clinic researchers are presenting final Phase 1 data from their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.

11 Dec 2025

New CDC grant supports expansion of colorectal cancer screening across rural Pennsylvania

Increasing colorectal cancer screening rates among communities with the greatest need is the goal of a five-year, $4.2 million grant from the Centers for Disease Control and Prevention (CDC) to Penn State College of Medicine.

11 Dec 2025

Researchers discover the enzyme responsible for chromothripsis in cancer

University of California San Diego researchers have discovered the enzyme responsible for chromothripsis, a process in which a single chromosome is shattered into pieces and rearranged in a scrambled order, allowing cancer cells to rapidly evolve and become resistant to treatment.

11 Dec 2025

Medicine News and Research

AI-guided discovery of selective DGKα inhibitors to overcome checkpoint resistance in solid cancers

Mass General Brigham launches AI company to enhance clinical trial matching

Acupuncture improves breast cancer survivors' perceived cognitive impairment

Mobile health intervention improves quality of life for adolescent and young adult breast cancer survivors

Researchers identify chromatin accessibility changes driving stem cell transformation in MDS

Most clinical trials fail to reflect America’s racial and ethnic diversity

Plant-based diets support healthy growth when properly planned for children

Increased epicardial fat volume linked to greater myocardial injury after infarction

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Advance care planning improves with automated patient outreach strategies

Smoke from Canadian wildfires linked to worse asthma symptoms in children

Breast arterial calcification on mammograms predicts future heart risk

New blood biomarker predicts brain damage after cardiac arrest

Study finds dramatic increase in ADHD medication use

Study offers insight into how coffee and tea intake may influence bone health in older women

Review highlights emerging role of tumor MHC-II in shaping cancer immunotherapy outcomes

Study reveals how Ebola and Marburg viruses damage the human gut

Cleveland Clinic reports promising results for breast cancer vaccine from final Phase 1 data

New CDC grant supports expansion of colorectal cancer screening across rural Pennsylvania

Researchers discover the enzyme responsible for chromothripsis in cancer

Everything there is to know about biosimilars eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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