Macrophage News and Research

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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

New immunotherapy treatment for cancer patients is more effective and less dangerous

Cell toxicity during immunotherapy is a major limitation to cancer treatment.

2 Jul 2021

How does dexamethasone therapy work in severe COVID-19?

The possible mechanisms that result in dexamethasone being an effective drug against severe SARS-CoV-2 infection are investigated in a new study. The paper’s authors advance the hypothesis that SARS-CoV-2 infection induces cell-specific insensitivity to glucocorticoids, possibly as an unintentional result of the viral replication cycle.

29 Jun 2021

Specific lung cell exhibits immune properties and improves respiratory viral disease outcomes

Researchers at Children's Hospital of Philadelphia have discovered that a specific type of lung cell exhibits unconventional immune properties and may contribute to the outcome of respiratory viral infections.

28 Jun 2021

Connective tissue protein promotes immune responses that fight bacterial infections

A connective tissue protein known to support the framework of organs also encourages immune responses that fight bacterial infections, while restraining responses that can be deadly in the condition called sepsis, a new study finds.

28 Jun 2021

Could the activation of FcγRIII/CD16 by anti-spike SARS-CoV-2 antibodies independently determine COVID-19 severity?

A team of scientists from Germany recently investigated whether hyperactivation of immune receptors that recognize the Fc part of an IgG molecule (FcγR) can lead to immunopathologic changes in coronavirus disease 2019 (COVID-19) patients. They have observed that hyperactivation of FcγRIII (CD16) by proinflammatory IgG antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can significantly contribute to COVID-19 related immunopathology.

28 Jun 2021

Vaccines and drugs must be adapted to combat emerging SARS-CoV-2 variants, says study

A new review of the emerging variants of concern (VOCs) of the SARS-CoV-2, which has caused the COVID-19 pandemic, shows that there is a major need to constantly re-evaluate the utility of existing therapeutics and vaccines against the virus and to develop new ones.

28 Jun 2021

TET enzymes play key role in keeping immune cells on a healthy track

Researchers at La Jolla Institute for Immunology (LJI) have shed light on a process in immune cells that may explain why some people develop cardiovascular diseases.

25 Jun 2021

Yeast-derived polysaccharide mixture effectively inhibits the onset, progression of immune disorders

The development of therapeutic drugs for inflammatory bowel disease, an intractable immune disease, and multiple sclerosis - an autoimmune disorder - is gaining traction.

25 Jun 2021

Anti-inflammatory nanoparticles could be applied to the weakening muscles of DMD patients

Muscular dystrophies are a group of genetic diseases that lead to the progressive loss of muscle mass and function in patients, with the incurable Duchenne Muscular Dystrophy (DMD), which affects all the body's muscles primarily in boys, being particularly severe.

25 Jun 2021

Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis

In a new study published in Circulation Research, Chen-Yu Zhang and Xiaohong Jiang's group from Nanjing University and Dongjin Wang's group from Nanjing Drum Tower Hospital reported a critical role of PGC1α in maintaining the contractile phenotype of vascular smooth muscle cells (VSMCs) and highlighted the therapeutic potential of PGC1α for atherosclerosis.

25 Jun 2021

UCLA scientists discover how immune cells can be trained to fight potential threats

The body's immune cells naturally fight off viral and bacterial microbes and other invaders, but they can also be reprogrammed or "trained" to respond even more aggressively and potently to such threats, report UCLA scientists who have discovered the fundamental rule underlying this process in a particular class of cells.

24 Jun 2021

CD39+ monocyte count higher in pregnant than non-pregnant COVID-19 patients

A new study published on the bioRxiv* server describes the changes in the representation of a subset of activated monocytes in this group of patients.

23 Jun 2021

Researchers analyze how breast implant surfaces influence immune response

Rice University bioengineers collaborated on a six-year study that systematically analyzed how the surface architecture of breast implants influences the development of adverse effects, including an unusual type of lymphoma.

21 Jun 2021

Researchers uncover the role of macrophages in liver growth after massive resections

RUDN University doctors found out what role macrophages play in the recovery of the liver after the removal of its significant part. The results are published in the journal Biomedicine & Pharmacotherapy.

21 Jun 2021

Can a prior rhinovirus infection protect against COVID-19?

Researchers at the Yale School of Medicine found that rhinovirus accelerates interferon-stimulated genes.

21 Jun 2021

Could a fungus-derived compound reduce hyperinflammation in severe COVID-19?

New research from scientists at the University of Pennsylvania, USA, demonstrates that cyclosporine A (CSA), a calcineurin inhibitor that modulates cytokine production, may have potential antiviral properties against coronaviruses.

18 Jun 2021

RIG-1 agonist shows potent antiviral efficacy against SARS-CoV-2 infection

A team of scientists from the United States has recently revealed the antiviral efficacy of stem-loop RNA 14, a RIG-1 agonist, in controlling severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in mice. The compound reduces the risk of severe coronavirus disease 2019 (COVID-19) by inhibiting viral replication in the lower respiratory tract. The study is currently available on the bioRxiv* preprint server.

18 Jun 2021

Macrophage News and Research

Further Reading

New immunotherapy treatment for cancer patients is more effective and less dangerous

How does dexamethasone therapy work in severe COVID-19?

Specific lung cell exhibits immune properties and improves respiratory viral disease outcomes

Connective tissue protein promotes immune responses that fight bacterial infections

Could the activation of FcγRIII/CD16 by anti-spike SARS-CoV-2 antibodies independently determine COVID-19 severity?

Vaccines and drugs must be adapted to combat emerging SARS-CoV-2 variants, says study

TET enzymes play key role in keeping immune cells on a healthy track

Yeast-derived polysaccharide mixture effectively inhibits the onset, progression of immune disorders

Anti-inflammatory nanoparticles could be applied to the weakening muscles of DMD patients

Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis

UCLA scientists discover how immune cells can be trained to fight potential threats

CD39+ monocyte count higher in pregnant than non-pregnant COVID-19 patients

Researchers analyze how breast implant surfaces influence immune response

Researchers uncover the role of macrophages in liver growth after massive resections

Can a prior rhinovirus infection protect against COVID-19?

Could a fungus-derived compound reduce hyperinflammation in severe COVID-19?

RIG-1 agonist shows potent antiviral efficacy against SARS-CoV-2 infection

Fighting the good fight –a new protein found in red blood cells linked to limiting cognitive decline

Texas Biomed scientists receive $1 million NIH funding for Ebola research

Nanodecoys made from human lung spheroid cells can neutralize SARS-CoV-2

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