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Dopamine receptor study opens door to targeted treatments for neuropsychiatric disorders

New work from researchers at Columbia University Vagelos College of Physicians and Surgeons sheds light on how dopamine receptors signal within cells, opening the door for more targeted--and more tolerable--therapeutics to treat an array of neuropsychiatric disorders.

4 Sep 2018

CSIRO project seeks to clear the air over potentially life-saving noble gases

Australia’s national science agency, CSIRO, partnered with world leader in medical gases, Air Liquide Healthcare, to reveal how the noble gases’ interactions with proteins could one day be used to treat a variety of health issues.

4 Sep 2018

Leukogene receives STTR grant to optimize compound for treatment-resistant multiple myeloma

A $2 million phase 2 Small Business Technology Transfer grant to optimize a promising new compound that has shown efficacy in preclinical studies against treatment-resistant multiple myeloma has been awarded to a Medical University of South Carolina startup company, Leukogene Therapeutics, Inc., in collaboration with MUSC researcher and company founder, Nathan G. Dolloff, Ph.D. Dolloff is an assistant professor in the Department of Cell and Molecular Pharmacology & Experimental Therapeutics at MUSC and a member of MUSC Hollings Cancer Center.

31 Aug 2018

Single dose of cannabidiol showed effective results in rats with symptoms of depression

Commercial antidepressants typically take two to four weeks to have a significant effect on a depressed patient. They are also inneffective in approximately 40% of the cases.

31 Aug 2018

Researchers take major step forward in finding safe and non-addictive pain killer

With the support of the National Institute on Drug Abuse, scientists at Wake Forest School of Medicine have been working to find a safe, non-addictive pain killer to help fight the current opioid crisis in this country.

30 Aug 2018

Cancer-hunting stem cells may be potential drug delivery tool for medulloblastoma

The latest in a series of laboratory breakthroughs could lead to a more effective way to treat the most common brain cancer in children.

30 Aug 2018

Study yields therapeutic clues to combat drug resistance in rare aggressive cancer

Stephen Elledge, PhD, and his team did not set out to find therapies that could render tumors less resistant to therapy or make existing drugs more potent against a rare form of cancer. But these are precisely the clinical insights that their most recent study has yielded.

29 Aug 2018

Peptilogics held pre-IND meeting with FDA to develop PLG0206 for treating prosthetic joint infections

Peptilogics, a development stage company utilizing its innovative peptide platform to treat multidrug-resistant bacterial infections, today announced it recently held a pre-Investigational New Drug (pre-IND) meeting with the U.S. Food and Drug Administration to discuss the regulatory pathway for the development of PLG0206 for the treatment of prosthetic joint infections.

25 Aug 2018

Forbius receives $18.75 million grant from CPRIT for Phase 2a development of AVID100

Forbius announced today that it has been awarded a Product Development grant totaling $18.75 million from the Cancer Prevention and Research Institute of Texas.

25 Aug 2018

New bioprinting method creates tubular structures that mimic vessels, ducts in the body

A team of Brigham and Women's Hospital researchers have developed a way to bioprint tubular structures that better mimic native vessels and ducts in the body.

25 Aug 2018

Inhibition of miR-24-3p may serve as potential treatment target for mesothelioma

Inhibition of miR-24-3p reduced growth of cancer cells and was found to regulate proteins as a potential treatment target for Mesothelioma.

25 Aug 2018

HU researchers develop new biological drug that may cure acute myeloid leukemia

Acute myeloid leukemia is one of the most aggressive cancers. While other cancers have benefited from new treatments, there has been no encouraging news for most leukemia patients for the past 40 years. Until now.

24 Aug 2018

Researchers use 'autobiographical memory' test for early prediction of Alzheimer's

Testing how well people remember past events in their lives could help medical professionals make early predictions about who is at risk for developing Alzheimer's disease, according to a new study from the University of Arizona.

24 Aug 2018

Comprehensive analysis reveals weaknesses to target in common pediatric solid tumor

St. Jude Children's Research Hospital investigators have completed the most comprehensive analysis yet of a common pediatric solid tumor, identifying weaknesses to target and a promising precision medicine that is now in clinical trials.

23 Aug 2018

Eye exam may one day help screen patients for Alzheimer's disease

It may be possible in the future to screen patients for Alzheimer's disease using an eye exam.

23 Aug 2018

Alzheimer’s screening may one day be carried out using an eye exam

New findings suggest that it may be possible to use an eye test to screen people for their risk of developing Alzheimer’s disease.

23 Aug 2018

Scientists publish study results of AAV therapy product for treatment of RHO-adRP

Ophthotech Corporation announced today that scientists at the University of Pennsylvania and University of Florida published proof-of-concept study results on an adeno-associated virus gene therapy product candidate for the treatment of rhodopsin-mediated autosomal dominant retinitis pigmentosa licensed by Ophthotech.

22 Aug 2018

Federal grant extends and expands research into acute kidney failure

The National Institute of Diabetes and Digestive and Kidney Diseases has renewed a grant shared by the University of Alabama at Birmingham School of Medicine and the University of California at San Diego School of Medicine that will extend and expand research into acute kidney failure, or acute kidney injury, which affects about 1.2 million hospitalized patients per year and kills 70 to 80 percent of patients in intensive care units who develop the disease.

22 Aug 2018

Researchers receive multi-million-dollar grant to expand kidney research

Researchers at University of California San Diego School of Medicine and the University of Alabama at Birmingham School of Medicine have received renewed grant funding from the National Institute of Diabetes and Digestive and Kidney Diseases to expand research into the areas of acute kidney failure and acute kidney injuries.

21 Aug 2018

Ultrasound methods could improve early detection of diseases in blood vessels, shows study

Ultrasound conducted before a patient develops symptoms could improve early detection of diseases in blood vessels, research led by the University of Leicester has shown.

21 Aug 2018

Preclinical News and Research

Dopamine receptor study opens door to targeted treatments for neuropsychiatric disorders

CSIRO project seeks to clear the air over potentially life-saving noble gases

Leukogene receives STTR grant to optimize compound for treatment-resistant multiple myeloma

Single dose of cannabidiol showed effective results in rats with symptoms of depression

Researchers take major step forward in finding safe and non-addictive pain killer

Cancer-hunting stem cells may be potential drug delivery tool for medulloblastoma

Study yields therapeutic clues to combat drug resistance in rare aggressive cancer

Peptilogics held pre-IND meeting with FDA to develop PLG0206 for treating prosthetic joint infections

Forbius receives $18.75 million grant from CPRIT for Phase 2a development of AVID100

New bioprinting method creates tubular structures that mimic vessels, ducts in the body

Inhibition of miR-24-3p may serve as potential treatment target for mesothelioma

HU researchers develop new biological drug that may cure acute myeloid leukemia

Researchers use 'autobiographical memory' test for early prediction of Alzheimer's

Comprehensive analysis reveals weaknesses to target in common pediatric solid tumor

Eye exam may one day help screen patients for Alzheimer's disease

Alzheimer’s screening may one day be carried out using an eye exam

Scientists publish study results of AAV therapy product for treatment of RHO-adRP

Federal grant extends and expands research into acute kidney failure

Researchers receive multi-million-dollar grant to expand kidney research

Ultrasound methods could improve early detection of diseases in blood vessels, shows study

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