Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

CNDA approves KEYTRUDA for treatment of advanced melanoma

Merck, known as MSD outside the United States and Canada, today announced that KEYTRUDA, Merck's anti-PD-1 therapy, has been approved by the China National Drug Administration for the treatment of adult patients with unresectable or metastatic melanoma following failure of one prior line of therapy.

26 Jul 2018

How soon is soon enough to learn you have Alzheimer’s?

Jose Belardo of Lansing, Kan., spent most of his career in the U.S. Public Health Service. He worked on the front lines of disasters in such places as Haiti, Colombia, Nicaragua and the Dominican Republic. At home with his three kids and wife, Elaine, he’d always been unfailingly reliable, so when he forgot their wedding anniversary two years in a row, they both started to worry.

26 Jul 2018

Newly identified target may lead to discovery of treatments for chronic inflammatory diseases

Inflammation is part of the body's natural healing process. But when it becomes chronic, inflammation can lead to cancer, Alzheimer's disease and other conditions.

26 Jul 2018

Study gives insights into how better clinical trials can address ‘critically low’ dementia research

New research gives insights into how the design of clinical trials can improve to address the "critically low" research pipeline and improve the chances of finding effective dementia therapies.

26 Jul 2018

Dizziness could be an early sign of dementia finds study

A new study has found that people who feel dizzy when they stand up from lying down or sitting positions, are more at risk of developing dementia or stroke. The study was published in the latest issue of the journal Neurology.

25 Jul 2018

Aggressive lowering of blood pressure reduces MCI risk, study shows

Significant reductions in the risk of mild cognitive impairment (MCI), and the combination of MCI and dementia, have been shown for the first time through aggressive lowering of systolic blood pressure in new research results from the federally-funded SPRINT MIND Study reported at the Alzheimer's Association International Conference 2018 in Chicago.

25 Jul 2018

Phase 3 study of KEYTRUDA monotherapy meets primary endpoint

Merck, known as MSD outside the United States and Canada, announced today that the pivotal Phase 3 KEYNOTE-048 trial investigating KEYTRUDA, Merck's anti-PD-1 therapy, for first-line treatment of recurrent or metastatic head and neck squamous cell carcinoma, met a primary endpoint of overall survival as monotherapy in patients whose tumors expressed PD-L1.

25 Jul 2018

Reduced plasmalogen level may increase risk of Alzheimer's disease, shows study

Reduced levels of plasmalogens - a class of lipids created in the liver that are integral to cell membranes in the brain - are associated with an increased risk of Alzheimer's Disease, according to new research presented this week at the Alzheimer's Association International Conference 2018 by Mitchel A. Kling, MD, an associate professor of Psychiatry in the Perelman School of Medicine at the University of Pennsylvania and the Veterans Affairs Medical Center.

25 Jul 2018

Turmeric derivative could be used in eye drops to treat early stages of glaucoma

A derivative of turmeric could be used in eye drops to treat the early stages of glaucoma, finds a new study led by UCL and Imperial College London researchers.

24 Jul 2018

Common opioid-based painkillers increase harmful side effects in people with dementia

Commonly-prescribed opioid-based painkillers led to harmful side effects tripling in people with dementia.

24 Jul 2018

Large-scale DNA sequence data on Alzheimer's disease to be made available to investigators

The National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site will begin making large-scale DNA sequence data available to investigators.

24 Jul 2018

New technique could provide insights about behavior of biomolecules in watery environments

Tinkering with a method they helped develop over the last few years, scientists have for the first time measured at the nanometer scale the characteristic patterns of folds that give proteins their three-dimensional shape in water.

24 Jul 2018

Roche receives Breakthrough Device Designation from FDA for new Alzheimer's disease assays

Roche announced today, that the U.S. Food and Drug Administration has granted Breakthrough Device Designation to Elecsys ß-Amyloid (1-42) CSF and Elecsys Phospho-Tau (181P) CSF.

From Roche Sequencing and Life Science 24 Jul 2018

Neurobiologists identify new link between smell and memory

Neurobiologists at the University of Toronto have identified a mechanism that allows the brain to recreate vivid sensory experiences from memory, shedding light on how sensory-rich memories are created and stored in our brains.

24 Jul 2018

Scientists find abnormal gene copying in fruit fly models of tauopathies

It sounds like science fiction: Nefarious genes clone themselves and settle their rogue copies in distant outposts of the galaxy (namely, our DNA), causing disease.

24 Jul 2018

Alzheimer’s disease greater in females, researchers speculate

This week, at the Alzheimer's Association International Conference in Chicago, a group of researchers presented reserch findings on the gender differences in Alzheimer’s causation. They speculated that women might be getting Alzheimer’s and dementia more commonly than men and the reason behind this has not been clearly understood. Estrogen or the female hormone could be the key, the researchers state.

23 Jul 2018

MODEL-AD Center releases eight new mouse models for Alzheimer's research

The MODEL-AD Center, an ambitious project to develop and distribute precise mouse models of late-onset Alzheimer's disease (AD), has released eight new models carrying genetic mutations found in patients.

23 Jul 2018

Virtual reality may improve empathy and understanding for older adults with dementia

Virtual reality technology gives high school students greater insight into what it's like to be Alfred -- a 74-year-old African American man with suspected mild cognitive impairment, plus age-related vision and hearing loss, or Beatriz, a middle-aged Latina, as she progresses through the continuum of Alzheimer's disease.

23 Jul 2018

Study reports data on dementia prevalence in sexual minority older adults

The first dementia prevalence data from a large population of lesbian, gay and bisexual older adults was reported today at the 2018 Alzheimer's Association International Conference in Chicago.

23 Jul 2018

New clinical practice guidelines for more accurate evaluation of Alzheimer's disease

Despite more than two decades of advances in diagnostic criteria and technology, symptoms of Alzheimer's disease and Related Dementias too often go unrecognized or are misattributed, causing delays in appropriate diagnoses and care that are both harmful and costly.

23 Jul 2018

Alzheimer's Disease News and Research

Further Reading

CNDA approves KEYTRUDA for treatment of advanced melanoma

How soon is soon enough to learn you have Alzheimer’s?

Newly identified target may lead to discovery of treatments for chronic inflammatory diseases

Study gives insights into how better clinical trials can address ‘critically low’ dementia research

Dizziness could be an early sign of dementia finds study

Aggressive lowering of blood pressure reduces MCI risk, study shows

Phase 3 study of KEYTRUDA monotherapy meets primary endpoint

Reduced plasmalogen level may increase risk of Alzheimer's disease, shows study

Turmeric derivative could be used in eye drops to treat early stages of glaucoma

Common opioid-based painkillers increase harmful side effects in people with dementia

Large-scale DNA sequence data on Alzheimer's disease to be made available to investigators

New technique could provide insights about behavior of biomolecules in watery environments

Roche receives Breakthrough Device Designation from FDA for new Alzheimer's disease assays

Neurobiologists identify new link between smell and memory

Scientists find abnormal gene copying in fruit fly models of tauopathies

Alzheimer’s disease greater in females, researchers speculate

MODEL-AD Center releases eight new mouse models for Alzheimer's research

Virtual reality may improve empathy and understanding for older adults with dementia

Study reports data on dementia prevalence in sexual minority older adults

New clinical practice guidelines for more accurate evaluation of Alzheimer's disease

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