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High-dose rifampicin does not improve survival in tuberculosis meningitis

Each year, 11 million people worldwide develop tuberculosis, and about 1.4 million die from it. Meningitis occurs in 1–2% of patients and is the most severe complication of tuberculosis, arising when the bacteria reach the brain.

17 Dec 2025

Study links low physical activity to higher lymphedema risk after cancer treatment

Lymphedema after head and neck cancer is considerably more common than previously assumed and can persist long after cancer treatment has finished.

17 Dec 2025

Nicotine pouch use rises sharply among young men in Great Britain

Use of nicotine pouches has risen substantially in Great Britain over the last five years, particularly among young men, with one in 13 (7.5%) men aged 16 to 24 now using them, according to a new study led by researchers at UCL (University College London).

17 Dec 2025

Global leaders adopt political declaration to combat NCDs and mental health challenges

Leaders from across the world at the Eightieth United Nations General Assembly (UNGA) have adopted the political declaration to combat noncommunicable diseases (NCDs) and mental health challenges through a fully integrated approach.

16 Dec 2025

Hydrogel-based treatment achieves innervation and pulp-dentin regeneration

The dental pulp is susceptible to microbial infection, which often results in inflammation, necrosis, and defects in the pulp-dentin complex. Traditional treatment strategies suffer from multiple limitations and do not promote neural regeneration.

16 Dec 2025

New data supports link between gum disease and heart disease

There is increasing evidence that gum disease is associated with increased risk of cardiovascular events, including heart attack, stroke, atrial fibrillation, heart failure and cardiometabolic health conditions. Effective prevention and treatment of gum disease, also called periodontal disease, could potentially decrease the burden of cardiovascular disease, according to a new scientific statement published today in the American Heart Association's flagship journal Circulation.

16 Dec 2025

Scientists map how cinnamon’s bioactives interact with cancer signaling

This review synthesizes preclinical evidence showing that cinnamon-derived compounds can modulate inflammation, oxidative stress, apoptosis, and angiogenesis through multiple cancer-related signaling pathways. While biologically plausible, the findings are largely limited to cell and animal models, underscoring the need for pharmacokinetic, safety, and clinical validation.

15 Dec 2025

What drinking kefir really does to your gut and oral microbiome

The impact of kefir on gut and oral microbiomes shows promise, but inconsistent findings and study limitations call for more rigorous scientific investigation.

15 Dec 2025

Understanding how the immune system protects against fungal pathogenicity

The yeast Candida albicans colonizes mucosal surfaces and is usually harmless. However, under certain conditions it can cause dangerous infections.

15 Dec 2025

Unnecessary gluten-free diets may put children at risk

Understanding gluten-related disorders is crucial for pediatric nutrition, as gluten-free diets can pose health risks without appropriate medical supervision.

15 Dec 2025

Combining inhibitors and chemotherapy enhances treatment for aggressive leukemia subtypes

While patients with acute myeloid leukemia (AML) are routinely treated with chemotherapy and other cell-killing therapies, existing options do not lead to favorable clinical outcomes in all patients.

12 Dec 2025

Exclusive licensing agreement accelerates PHD inhibitor development for anemia in CKD patients

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, and TaiGen Biotechnology, a listed discovery-based and market-focused pharmaceutical company, as well as TaiGen Biopharmaceuticals, its wholly-owned Beijing subsidiary (both referred to as "TaiGen"), today announced an exclusive pipeline out-licensing collaboration.

12 Dec 2025

Distinct transcriptomic profiles guide early development of maxillary and mandibular teeth

The interaction between genetics and tissue environment shapes how individual teeth form in different regions of the jaw.

12 Dec 2025

AI-guided discovery of selective DGKα inhibitors to overcome checkpoint resistance in solid cancers

Insilico Medicine has developed a new class of small molecule inhibitors targeting diacylglycerol kinase alpha (DGKα) designed to restore T cell function and overcome resistance to immune checkpoint blockades in solid cancers.

12 Dec 2025

Single-dose pill shows promise against antibiotic-resistant gonorrhoea

A single-dose oral medication called zoliflodacin shows promise as a new treatment for antibiotic-resistant gonorrhoea, according to a phase 3 clinical trial published in The Lancet.

11 Dec 2025

Machine learning reveals dental caries heterogeneity in NHANES

A new article published in the Journal of Dental Research explores the development an integrated data-cleaning and subtype discovery pipeline using unsupervised machine learning for comprehensive analysis and visualization of data patterns in the National Health and Nutrition Examination Survey (NHANES) database.

11 Dec 2025

Frequency and quantity of alcohol consumption influence cancer risk

As Americans gear up for the holiday season, new research offers a timely reminder to reflect on the long-term health effects of raising a celebratory glass – or two.

11 Dec 2025

Why the form of vitamin B12 you take may matter more than your intake

This comprehensive review examines vitamin B12 absorption, physiological roles, deficiency states, and dietary sources, with particular attention to differences between natural and synthetic forms. The authors conclude that while all B12 forms raise circulating levels, methylcobalamin may offer advantages in specific clinical contexts, especially where absorption or metabolic conversion is impaired.

10 Dec 2025

Early warning for diabetes: AI model identifies prediabetes risk with high accuracy

A Scientific Reports study developed a pattern neural network that integrates total antioxidant status with clinical and metabolic markers to predict prediabetes in Indian adults. The model achieved very high accuracy and highlighted oxidative stress and waist circumference as key predictors, supporting earlier detection before progression to type 2 diabetes.

10 Dec 2025

Researchers unravel why mRNA-based vaccines for COVID-19 can cause heart damage

Stanford Medicine investigators have unearthed the biological process by which mRNA-based vaccines for COVID-19 can cause heart damage in some young men and adolescents - and they've shown a possible route to reducing its likelihood.

10 Dec 2025

Oral News and Research

High-dose rifampicin does not improve survival in tuberculosis meningitis

Study links low physical activity to higher lymphedema risk after cancer treatment

Nicotine pouch use rises sharply among young men in Great Britain

Global leaders adopt political declaration to combat NCDs and mental health challenges

Hydrogel-based treatment achieves innervation and pulp-dentin regeneration

New data supports link between gum disease and heart disease

Scientists map how cinnamon’s bioactives interact with cancer signaling

What drinking kefir really does to your gut and oral microbiome

Understanding how the immune system protects against fungal pathogenicity

Unnecessary gluten-free diets may put children at risk

Combining inhibitors and chemotherapy enhances treatment for aggressive leukemia subtypes

Exclusive licensing agreement accelerates PHD inhibitor development for anemia in CKD patients

Distinct transcriptomic profiles guide early development of maxillary and mandibular teeth

AI-guided discovery of selective DGKα inhibitors to overcome checkpoint resistance in solid cancers

Single-dose pill shows promise against antibiotic-resistant gonorrhoea

Machine learning reveals dental caries heterogeneity in NHANES

Frequency and quantity of alcohol consumption influence cancer risk

Why the form of vitamin B12 you take may matter more than your intake

Early warning for diabetes: AI model identifies prediabetes risk with high accuracy

Researchers unravel why mRNA-based vaccines for COVID-19 can cause heart damage

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