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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

Analyzing the evolution of SARS-CoV-2 RNA polymerase in humans

In a new study, researchers examined the impact of mutations on the structural thermodynamic stability (structural stability) of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) through free energy computation.

11 Jan 2022

Single-step RT-PCR for SARS-CoV-2 Omicron variant detection in respiratory samples

A new preprint describes a single-step molecular diagnostic test for the presence of SARS-CoV-2 infection caused by the Omicron variant that is behind the unprecedented rise in cases over the last few weeks.

11 Jan 2022

NeoCura and PhoreMost Announce Research Collaboration to Explore Novel Cancer Therapeutics

NeoCura and PhoreMost today announced an oncology drug discovery research collaboration.

From PhoreMost 11 Jan 2022

Development and validation of 2-gene host-based COVID-19 diagnostic classifiers

A group of researchers from Biohub has been attempting to create a more accurate method for PCR testing.

11 Jan 2022

SARS-CoV-2 activates microglia in the brain

Researchers demonstrate that SARS-CoV-2 can infect the human microglia.

10 Jan 2022

SARS-CoV-2 levels decrease when human SIRT5 is deleted or inhibited

Researchers examine the role of human sirtuin 5 (SIRT5) in SARS-CoV-2 infection.

10 Jan 2022

SARS-CoV-2 spike engagement of ACE2 shown to prime S2′ site cleavage and fusion initiation

In a new study, researchers used a cell-cell fusion assay to extract potentially cleaved spike protein products from syncytia in order to explore the functional and biochemical characteristics of spike (S) protein when it engages its receptor ACE2 in living cells.

10 Jan 2022

New lab-on-a-chip platform for detecting SARS-CoV-2 in resource-limited settings

A recent study shows how a novel and integrated lab-on-a-chip platform can represent a rapid, affordable, and exact molecular diagnostic tool for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The paper is currently available for free on the medRxiv* preprint server while it undergoes peer review.

9 Jan 2022

Bolstering current therapeutic antibody treatments to help fight Omicron infections

Researchers test the neutralizing action of a panel of eight therapeutic monoclonal antibodies against the SARS-CoV-2 Omicron (B.1.1.529) variant.

9 Jan 2022

Lab engineered human A549 lung cell model conducive for investigating SARS-CoV-2 antivirals

Researchers developed a human A549 lung epithelial cell-based model to probe SARS-CoV-2 replication.

9 Jan 2022

Researchers set the framework for improved colorectal cancer surveillance using precision medicine

A team of Vanderbilt researchers has revealed some of the mechanisms by which polyps develop into colorectal cancer, setting the framework for improved surveillance for the cancer utilizing precision medicine.

7 Jan 2022

Researchers investigate SARS-CoV-2 specific inflammatory response

New research can confirm that while some of the response from monocytes to SARS-CoV-2 is generic to virus infection, most of it SARS-CoV-2 specific, especially proinflammatory responses.

7 Jan 2022

Model suggests feasibility of shorter COVID-19 isolation period with minimal risk

Researchers set up a model that included parameters such as the infectiousness of the individual, and lateral flow testing, in order to assess the effectiveness of test-to-release policies as compared to those with fixed-duration isolation mandates

7 Jan 2022

Researchers isolate Omicron variant, leveling the path to vaccine development and vaccine efficacy studies

Researchers from India have now successfully grown and isolated the Omicron variant from hamsters in vivo with further culturing in the Vero CCL-81 cells in vitro, in a step forward towards testing the effectiveness of existing SARS-CoV-2 vaccines and generation of new Omicron appropriate vaccines.

7 Jan 2022

Moderna announces initiation of Phase 1 study of its mRNA-1189 EBV vaccine candidate

Moderna, Inc., a biotechnology company pioneering messenger RNA therapeutics and vaccines, today announced the first participant has been dosed in the Phase 1 study of mRNA-1189, the Company's Epstein-Barr Virus vaccine candidate.

7 Jan 2022

Curia unveils comprehensive mRNA solution

Curia, formerly AMRI, a leading contract research, development and manufacturing organization, today unveiled its messenger RNA solution, which includes discovery, process development and mRNA drug substance production, through large-scale lipid manufacturing, lipid nanoparticle formulation and development for full-scale sterile fill-finish services.

From Curia Global, Inc. 7 Jan 2022

From laboratory to clinic - Nanotechnology-enabled mRNA COVID-19 vaccines

In a recently published article in the journal Nano-Micro Letters, scientists have provided an in-depth review on the application and benefits of nanotechnology in the development of coronavirus disease 2019 (COVID-19) vaccines.

7 Jan 2022

SARS-CoV-2 Omicron less pathogenic in hamsters

A new research paper posted as a preprint to the bioRxiv* server attempts to throw some light on this question by studying viral pathogenicity in golden hamsters, a valuable model for severe COVID-19 due to the development of reproducible weight loss and pneumonia after infection with the virus.

6 Jan 2022

Evaluating the response of lung cancer patients to COVID-19 mRNA vaccination

Researchers examine the efficacy of mRNA COVID-19 vaccination in NSCLC patients.

6 Jan 2022

New approach with mRNA preparation reprograms T cells to attack heart fibroblasts

An experimental immunotherapy can temporarily reprogram patients' immune cells to attack a specific target via only a single injection of messenger RNA (mRNA), similar to the mRNA-based COVID-19 vaccines, according to a new study from researchers in the Perelman School of Medicine at the University of Pennsylvania.

6 Jan 2022

RNA News and Research

Further Reading

Analyzing the evolution of SARS-CoV-2 RNA polymerase in humans

Single-step RT-PCR for SARS-CoV-2 Omicron variant detection in respiratory samples

NeoCura and PhoreMost Announce Research Collaboration to Explore Novel Cancer Therapeutics

Development and validation of 2-gene host-based COVID-19 diagnostic classifiers

SARS-CoV-2 activates microglia in the brain

SARS-CoV-2 levels decrease when human SIRT5 is deleted or inhibited

SARS-CoV-2 spike engagement of ACE2 shown to prime S2′ site cleavage and fusion initiation

New lab-on-a-chip platform for detecting SARS-CoV-2 in resource-limited settings

Bolstering current therapeutic antibody treatments to help fight Omicron infections

Lab engineered human A549 lung cell model conducive for investigating SARS-CoV-2 antivirals

Researchers set the framework for improved colorectal cancer surveillance using precision medicine

Researchers investigate SARS-CoV-2 specific inflammatory response

Model suggests feasibility of shorter COVID-19 isolation period with minimal risk

Researchers isolate Omicron variant, leveling the path to vaccine development and vaccine efficacy studies

Moderna announces initiation of Phase 1 study of its mRNA-1189 EBV vaccine candidate

Curia unveils comprehensive mRNA solution

From laboratory to clinic - Nanotechnology-enabled mRNA COVID-19 vaccines

SARS-CoV-2 Omicron less pathogenic in hamsters

Evaluating the response of lung cancer patients to COVID-19 mRNA vaccination

New approach with mRNA preparation reprograms T cells to attack heart fibroblasts

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