Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Neoadjuvant clinical trial of immune checkpoint blockade for melanoma patients yields high response rate

Combination checkpoint blockade before surgery (neoadjuvant therapy) produced a high response rate among patients with high-risk stage 3 melanoma, with nearly half having no sign of disease at surgery, but a high incidence of side effects caused the trial to be closed early.

8 Oct 2018

Immunotherapy effective for individuals with inherited form of skin cancer

Individuals with an inherited form of skin cancer often have a poor prognosis. The type of immunotherapy that was awarded this year's Nobel Prize in Physiology or Medicine is, however, particularly effective in this patient group, research from Karolinska Institutet in Sweden shows. The study is published in the Journal of Medical Genetics.

8 Oct 2018

Study analyzes distribution of two cytokines in sections of carotid atherosclerotic plaques

Inflammation is currently a well-documented component of atheroslcerosis pathogenesis, which plays a role at each stage of the disease development.

6 Oct 2018

RNA sequencing method uncovers new insights into biological events in heart disease

Scientists using a powerful new technology that sequences RNA in 20,000 individual cell nuclei have uncovered new insights into biological events in heart disease.

5 Oct 2018

Study reveals factors linked to the development of Crohn's disease

How cells talk to each other, and what they say, has long held fascination for Seema Khurana, professor of biology and biochemistry.

5 Oct 2018

Wits doctors transplant liver from HIV positive mother to her child with end-stage liver disease

This was the ethical dilemma faced by doctors at Wits Donald Gordon Medical Centre to save a child's life.

4 Oct 2018

Viruses shown to cause bowel dysfunction and abdominal pain

Viruses known to target the central nervous system may also affect neurons of the digestive tract, causing bowel dysfunction and abdominal pain.

4 Oct 2018

Researchers obtain understanding of pathomechanisms underlying two age-related eye disorders

Population aging is a global phenomenon with profound medical implications. Tissue dysfunction associated with aging affects all vital organs, including the eyes.

3 Oct 2018

Alnylam submits CTA application to MHRA to initiate Phase 1/2 study of ALN-AAT02

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today that it has submitted a Clinical Trial Authorization application to the Medicines and Healthcare products Regulatory Agency to initiate a Phase 1/2 study of ALN-AAT02, an investigational RNAi therapeutic targeting alpha-1 antitrypsin for the treatment of AAT deficiency-associated liver disease.

3 Oct 2018

New portable medical devices allow real-time monitoring of therapy efficacy and pathology evolution

Thirteen new PhD students are embarking on a research journey in the area of microwave imaging this month, as part of the EU project EMERALD - ElectroMagnetic imaging for a novel genERation of medicAL Devices.

3 Oct 2018

TEAD1 protein appears to be important regulator of tumor migration in glioblastoma

A specific protein called TEAD1 is an important regulator of tumor migration in glioblastoma, the most common brain tumor in adults, and deactivating this protein may stop tumor cells from migrating away from the main tumor mass, according to research conducted at the Icahn School of Medicine at Mount Sinai and published October 1 in the journal Nature Communications.

1 Oct 2018

Study highlights role of non-mutational mechanism in myotonic dystrophy, other types of arrhythmias

A team of researchers at Baylor College of Medicine reveals new insights into what can be causing life-threatening cardiac-related events in myotonic dystrophy type 1.

28 Sep 2018

New combination therapy shows potential in treating incurable HPV-related cancers

A tumor-specific vaccine combined with an immune checkpoint inhibitor shrank tumors in one third of patients with incurable cancer related to the human papilloma virus (HPV) in a phase II clinical trial led by investigators at The University of Texas MD Anderson Cancer Center and reported in JAMA Oncology.

28 Sep 2018

UCI researchers receive $3.4 million grant to study new class of cancer killing immunotherapeutics

UCI School of Medicine researchers have been awarded a $3.4 million grant by the National Cancer Institute as part of the Beau Biden Cancer Moonshot initiative.

27 Sep 2018

Biological 'switch' influences whether immature blood cells differentiate into red or white blood cells

Japanese scientists have revealed a biological "switch" that influences whether an immature blood cell would develop into a red blood cell or a subtype of white blood cell called myeloid cells in response to infection or inflammation within the body.

26 Sep 2018

Study: Second opinion can potentially change the diagnosis of breast cancer patients

It's early morning and a team of more than 20 professionals cram around a long table in a dark room, peering at slide after slide of black-and-white mammogram images crossing the screen.

26 Sep 2018

Alzheimer’s disease researchers makes significant breakthroughs

Researchers in Sweden and United Kingdom have made a breakthrough in Alzheimer’s disease research. They could soon be on the path to develop new drugs that could fight the disease more effectively.

26 Sep 2018

UCI study finds new cause of cerebral microbleeds

A team of researchers including UCI project scientist Rachita Sumbria, PhD and UCI neurologist Mark J. Fisher, MD have provided, for the first time, evidence that blood deposits in the brain may not require a blood vessel tear.

25 Sep 2018

Novel drug alleviates memory deficits and neuropathology in Alzheimer's animal model

New research conducted at the Lady Davis Institute at the Jewish General Hospital reveals that a novel drug reverses memory deficits and stops Alzheimer disease pathology in an animal model.

25 Sep 2018

Researchers develop molecule that makes cancer cells sensitive to radiotherapy

Researchers from Karolinska Institutet and Kancera AB have developed a molecule that makes cancer cells sensitive to radiotherapy. In a study published in Nature Communications, the researchers describe a new way to block cancer cells' ability to repair their DNA and thus stop the survival of cancer cells.

25 Sep 2018

Pathology News and Research

Further Reading

Neoadjuvant clinical trial of immune checkpoint blockade for melanoma patients yields high response rate

Immunotherapy effective for individuals with inherited form of skin cancer

Study analyzes distribution of two cytokines in sections of carotid atherosclerotic plaques

RNA sequencing method uncovers new insights into biological events in heart disease

Study reveals factors linked to the development of Crohn's disease

Wits doctors transplant liver from HIV positive mother to her child with end-stage liver disease

Viruses shown to cause bowel dysfunction and abdominal pain

Researchers obtain understanding of pathomechanisms underlying two age-related eye disorders

Alnylam submits CTA application to MHRA to initiate Phase 1/2 study of ALN-AAT02

New portable medical devices allow real-time monitoring of therapy efficacy and pathology evolution

TEAD1 protein appears to be important regulator of tumor migration in glioblastoma

Study highlights role of non-mutational mechanism in myotonic dystrophy, other types of arrhythmias

New combination therapy shows potential in treating incurable HPV-related cancers

UCI researchers receive $3.4 million grant to study new class of cancer killing immunotherapeutics

Biological 'switch' influences whether immature blood cells differentiate into red or white blood cells

Study: Second opinion can potentially change the diagnosis of breast cancer patients

Alzheimer’s disease researchers makes significant breakthroughs

UCI study finds new cause of cerebral microbleeds

Novel drug alleviates memory deficits and neuropathology in Alzheimer's animal model

Researchers develop molecule that makes cancer cells sensitive to radiotherapy

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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