Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Review shows lecanemab and donanemab slow decline and explains who should get them

The Lancet review synthesises evidence on anti beta amyloid monoclonal antibodies and the wider Alzheimer’s care pathway, weighing efficacy, safety, economics, and health system readiness across disease, patient, and population perspectives.

24 Sep 2025

Blood and brain biomarkers transform how doctors confirm Alzheimer’s disease

A new Lancet review proposes a three-wave diagnostic pathway that combines clinical expertise with blood, CSF, and PET biomarkers. This approach aims to deliver earlier, more accurate, and more equitable Alzheimer’s disease diagnosis worldwide.

24 Sep 2025

New diagnostic methods and treatments needed to fight against Alzheimer's disease

The diagnosis and medical treatment of Alzheimer's disease, a condition that according to leading researchers in the field should be treated, has now advanced significantly.

24 Sep 2025

High levels of albumin in the urine linked to increased risk of dementia

A study shows that people with higher levels of the protein albumin in their urine are at increased risk of developing dementia. The study, led by researchers at Karolinska Institutet, is published in the scientific journal Journal of Internal Medicine.

24 Sep 2025

NIH funds USC team to develop a selective Alzheimer’s drug for APOE4 carriers

Backed by the combined expertise of three USC schools, scientists are developing a new drug aimed at a previously unexplored biological target in Alzheimer's disease, aided by an $8 million grant from the National Institutes of Health.

23 Sep 2025

UNM researcher develops new model for characterizing different forms of vascular dementia

Vascular dementia - cognitive impairment caused by disease in the brain's small blood vessels - is a widespread problem, but it has not been as thoroughly studied as Alzheimer's disease, in which abnormal plaques and protein tangles are deposited in neural tissue.

19 Sep 2025

Advanced imaging exposes breakdown in brain cell communication linked to Alzheimer’s

Research led by The Ohio State University Wexner Medical Center and College of Medicine explores the ways brain cells communicate, revealing fresh insight into the progression of Alzheimer's disease.

18 Sep 2025

High fat diet impairs memory formation through autophagy dysfunction

Modern lifestyles and dietary changes have significantly increased the consumption of high-fat foods, contributing to a steep rise in the prevalence of obesity, diabetes, and metabolic disorders.

17 Sep 2025

Two-step blood and scan strategy delivers near-perfect accuracy for early Alzheimer's signs

Plasma p-tau217 testing can help detect preclinical Alzheimer disease in cognitively unimpaired adults. Using it as a first-line screen followed by positron emission tomography or cerebrospinal fluid testing boosts accuracy, reduces false positives, and streamlines recruitment.

16 Sep 2025

AI breakthrough offers a new way to predict and visualize disease processes

To solve a problem, we have to see it clearly. Whether it's an infection by a novel virus or memory-stealing plaques forming in the brains of Alzheimer's patients, visualizing disease processes in the body is the first step toward alleviating human suffering. It's also often the most difficult and costly.

16 Sep 2025

Age influences amyloid positivity in Parkinson's disease without dementia

A new research paper was published in Volume 17, Issue 8 of Aging-US on August 6, 2025, titled "Age-related trends in amyloid positivity in Parkinson's disease without dementia."

16 Sep 2025

Lifestyle changes show promise in preventing cognitive decline and Alzheimer’s disease

An estimated 7.2 million Americans over age 65 currently live with Alzheimer's disease (AD). That number is expected to nearly double to 13.8 million by 2060.

16 Sep 2025

Study uncovers how the brain flexibly switches communication routes

When we recall something familiar or explore a new situation, the brain does not always use the same communication routes.

16 Sep 2025

Boosting PI31 to restore synaptic function and prevent neurodegeneration

One fundamental feature of neurodegenerative diseases is a breakdown in communication. Even before brain cells die, the delicate machinery that keeps neurons in touch-by clearing away protein waste at the synapses-starts to fail.

16 Sep 2025

Researchers develop a digital cognitive test for diagnosing Alzheimer's disease

Researchers at Lund University in Sweden have developed a digital cognitive test for diagnosing Alzheimer's disease that is intended for use in primary care.

15 Sep 2025

Researchers reveal why global gains against chronic diseases are stalling

Researchers analysed mortality data from 185 countries and found that while global non-communicable disease (NCD) deaths before age 80 declined from 2010 to 2019, progress slowed compared to 2001–2010. Gains were mainly from drops in heart disease and stroke, but rising burdens from diabetes, cancers, and neuropsychiatric conditions stalled momentum.

15 Sep 2025