Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

New CHEST guidelines offer evidence-based biologic selection for severe asthma

The American College of Chest Physicians (CHEST) recently released a new clinical guideline on biologic management in severe asthma.

13 Jan 2026

Common food preservatives may raise cancer risk

Higher intake of certain food preservatives is associated with increased cancer rates, particularly breast and prostate cancers, highlighting safety concerns.

13 Jan 2026

Biohybrid skin graft: A fluorescent window into internal health monitoring

Wearable health devices, such as smartwatches, have become commonplace, enabling the continuous monitoring of physiological signals at the skin's surface.

13 Jan 2026

Long-term diabetes changes red blood cells, increasing cardiovascular disease risk

The longer a person has type 2 diabetes, the greater the risk of cardiovascular disease. A new study from Karolinska Institutet, published in the journal Diabetes, shows that changes in red blood cells may be an important explanation, and identifies a specific molecule as a possible biomarker.

9 Jan 2026

Study reveals innate immune barriers to long-term pig kidney transplant survival

Pioneering research led by Brazilians describes the immune system's reactions in detail in the first living patient to receive a genetically modified pig kidney transplant.

8 Jan 2026

Exposure to micro- and nanoplastics linked to rising number of people with chronic IBD

A research team led by the Medical University of Vienna and the University of Vienna has investigated a possible link between the rising number of people with chronic inflammatory bowel disease and the increasing exposure to micro- and nanoplastics (MNPs).

8 Jan 2026

Low-dose megestrol strengthens hormone therapy in ER-positive breast cancer

Low-dose megestrol enhances hormone therapy for ER-positive breast cancer, reducing tumor proliferation and improving treatment adherence in the PIONEER trial.

7 Jan 2026

A single immune protein may help explain why kidney and heart disease often develop together

This review synthesizes clinical, genetic, and mechanistic evidence showing that suPAR and related uPAR fragments are strongly associated with kidney, cardiovascular, and metabolic disease risk. It highlights suPAR as a stable biomarker of innate immune activation with potential pathogenic roles, while underscoring major gaps in assay standardization and therapeutic validation.

6 Jan 2026

Restoring brain energy balance reverses advanced Alzheimer’s disease in mouse models

For over a century, Alzheimer's disease (AD) has been considered irreversible. Consequently, research has focused on disease prevention or slowing, rather than recovery.

6 Jan 2026

Finger-prick blood test shows promise for detecting Alzheimer’s disease biology

Finger-prick dried blood sampling can accurately measure key Alzheimer’s disease biomarkers, including p-tau217, GFAP, and NfL, showing strong concordance with venous plasma and meaningful associations with CSF pathology. While analytical limitations remain, this minimally invasive approach shows promise as a scalable research and screening tool within biomarker-based diagnostic pathways.

6 Jan 2026

Elevated neutrophil-to-lymphocyte ratio linked to depression and suicide risk

An elevated neutrophil-to-lymphocyte ratio (NLR) is significantly associated with increased risk of depressive disorder (DD) and may also correlate with suicide risk among individuals with DD, according to a systematic review and meta-analysis published in the November issue of Harvard Review of Psychiatry, part of the Lippincott portfolio from Wolters Kluwer.

6 Jan 2026

Streptococcus anginosus metabolites fuel gastric cancer

A recent study published in the medical journal Gut has revealed a novel cancer-promoting mechanism of Streptococcus anginosus (Sa).

6 Jan 2026

New evidence reveals Streptococcus anginosus promotes gastric cancer development

This study identifies a cancer-promoting mechanism of Streptococcus anginosus, linking microbial metabolism to gastric cancer and enhancing prevention efforts.

From BGI Genomics 6 Jan 2026

Why individual differences hold the key to unlocking psychiatric mysteries

In a revealing Genomic Press Interview published today in Genomic Psychiatry, Dr. Noritaka Ichinohe challenges a foundational assumption that has quietly constrained psychiatric research for decades: the belief that meaningful explanation requires averaging away individual differences.

6 Jan 2026

Two isoforms of a cellular energy sensor play distinct, opposing roles in Alzheimer's disease

A comprehensive mini-review published today after peer review in Brain Medicine by Dr. Tao Ma and colleagues at Wake Forest University School of Medicine synthesizes emerging evidence that two isoforms of a critical cellular energy sensor play distinct, and sometimes opposing, roles in Alzheimer's disease.

6 Jan 2026

Finger-prick blood tests enable remote detection of Alzheimer’s biomarkers

A groundbreaking international study has demonstrated that Alzheimer's disease biomarkers can be accurately detected using simple finger-prick blood samples that can be collected at home and mailed to laboratories without refrigeration or prior processing.

5 Jan 2026

Common blood signals explain why chronic diseases cluster as we age

This population-based study shows that shared and pattern-specific blood biomarkers reflect biological vulnerability underlying multimorbidity and the pace at which chronic diseases accumulate in older adults. Metabolic and systemic stress markers such as GDF15, HbA1c, cystatin C, and insulin consistently tracked higher disease burden and faster accumulation, with findings replicated across cohorts.

5 Jan 2026