Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

Insilico Medicine announces preclinical drug discovery benchmarks from 2021 to 2024

Insilico Medicine ( "Insilico") , a clinical stage generative artificial intelligence (AI)-driven biotechnology company today announced a set of preclinical drug discovery benchmarks from the 22 developmental candidate nominations achieved by its platform from 2021 to 2024.

11 Feb 2025

Insilico Medicine develops highly selective FGFR2/3 dual inhibitor for cancer treatment

Fibroblast growth factor receptors (FGFRs) are critical drivers of oncogenesis in various solid tumors, including urothelial carcinoma, hepatocellular carcinoma, ovarian cancer and lung adenocarcinoma.

7 Feb 2025

Collagen's structural diversity may be greater than previously believed, study suggests

Collagen, the body's most abundant protein, has long been viewed as a predictable structural component of tissues.

7 Feb 2025

Early immune system changes contribute to lung damage in cystic fibrosis

Despite new medication, cystic fibrosis often leads to permanent lung damage. Working with an international team, researchers from the Technical University of Munich (TUM) have discovered that the disease causes changes in the immune system early in life, presumably even in newborns.

7 Feb 2025

Alcohol and preexisting health conditions raise risk of advanced liver disease

Why do some people who consume a few glasses of alcohol a day develop advanced liver disease while others who drink the same amount don't?

7 Feb 2025

New medication-based approach reverses inguinal hernias in mice

By age 75, a noteworthy 50% of men develop an inguinal (groin) hernia - a bulge that results from soft tissue pushing through a weak spot in the abdominal muscles.

5 Feb 2025

Study links low levels of PM2.5 exposure to liver damage

Researchers examine the liver toxicity of low levels of PM2.5 exposure.

5 Feb 2025

Lurie Children's launches campaign to raise awareness of newborn screening

Ann & Robert H. Lurie Children's Hospital of Chicago launched a newborn screening awareness campaign, with signage on public transit and billboards across Chicago urging parents to contact their child's pediatrician immediately if results are out of normal range.

3 Feb 2025

Traffic-related air pollution may raise the risk of metabolic-associated fatty liver disease

Long-term exposure to low levels of traffic-related air pollution harms the liver and may raise the risk of metabolic-associated fatty liver disease, a new study in mice suggests.

31 Jan 2025

Study highlights novel approaches to treating diabetic cardiomyopathy

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Diabetic cardiomyopathy (DCM) is a specific type of cardiomyopathy that is independent of hypertension and coronary artery disease, and is closely associated with the high incidence and mortality of heart failure in people with diabetes.

27 Jan 2025

New procedure standard/practice guideline released for fibroblast activation protein PET

The Society of Nuclear Medicine and Molecular Imaging (SNMMI) and the European Association of Nuclear Medicine (EANM) have issued a new procedure standard/practice guideline for the use of fibroblast activation protein (FAP) PET.

25 Jan 2025

Key immune cells required for tissue repair following liver injury

Our livers contain many different types of immune cells. New research by the team of Prof. Charlotte Scott (VIB-UGent Center for Inflammation Research) and colleagues now reveals that a specific activation state of one of these cell types is required for tissue repair following injury.

24 Jan 2025

USF study: Pulmonary fibrosis after COVID-19 tends to get better

Pulmonary fibrosis is a rare, chronic disease that causes scarring in the lungs, making breathing difficult for people who suffer with it.

23 Jan 2025

Insilico Medicine doses first patient in Phase I Trial of ISM6331 for mesothelioma

Insilico Medcine( "Insilico") , a clinical stage generative artificial intelligence (AI)-driven biotechnology company today announced the first patient has been dosed in the global multicenter Phase I Trial of ISM6331, a novel pan-TEAD inhibitor developed from Insilico's generative chemistry engine Chemistry42, for the treatment of mesothelioma and other solid tumors.

22 Jan 2025

New rabbit model provides insights into CF-related pancreatic endocrine pathology

Cystic fibrosis (CF) is a life-threatening genetic disease affecting multiple organ systems, with pancreatic dysfunction representing a critical and often overlooked complication.

17 Jan 2025

SOX9 overexpression protects against lipid accumulation in MASH via AMPK activation

The transcription factor sex-determining region Y-related high-mobility group-box gene 9 (SOX9) plays a critical role in organ development.

17 Jan 2025

Drug in breast cancer trials shows potential for treating blood cancers

Two new studies led by researchers at Washington University School of Medicine in St. Louis have identified a possible way to block the progression of several forms of blood cancer using a drug already in clinical trials against breast cancer.

16 Jan 2025

Study unravels the links between obesity and cancer

Obesity, recognized as a complex and growing health issue, is associated with an increased risk of various cancers. A comprehensive review provides insights into the mechanisms linking obesity to cancer risk and discusses potential clinical implications.

15 Jan 2025

Researchers uncover role of perivascular cells in blood vessel dysfunction

Researchers at Oregon Health & Science University have uncovered how specialized cells surrounding small blood vessels, known as perivascular cells, contribute to blood vessel dysfunction in chronic diseases such as cancer, diabetes and fibrosis.

13 Jan 2025

Women experience higher waiting-list mortality in lung transplantation

Research highlights gender-based disparities in lung transplantation, showing women face longer wait times yet achieve better post-transplant survival outcomes.

13 Jan 2025

Fibrosis News and Research

Further Reading

Insilico Medicine announces preclinical drug discovery benchmarks from 2021 to 2024

Insilico Medicine develops highly selective FGFR2/3 dual inhibitor for cancer treatment

Collagen's structural diversity may be greater than previously believed, study suggests

Early immune system changes contribute to lung damage in cystic fibrosis

Alcohol and preexisting health conditions raise risk of advanced liver disease

New medication-based approach reverses inguinal hernias in mice

Study links low levels of PM2.5 exposure to liver damage

Lurie Children's launches campaign to raise awareness of newborn screening

Traffic-related air pollution may raise the risk of metabolic-associated fatty liver disease

Study highlights novel approaches to treating diabetic cardiomyopathy

New procedure standard/practice guideline released for fibroblast activation protein PET

Key immune cells required for tissue repair following liver injury

USF study: Pulmonary fibrosis after COVID-19 tends to get better

Insilico Medicine doses first patient in Phase I Trial of ISM6331 for mesothelioma

New rabbit model provides insights into CF-related pancreatic endocrine pathology

SOX9 overexpression protects against lipid accumulation in MASH via AMPK activation

Drug in breast cancer trials shows potential for treating blood cancers

Study unravels the links between obesity and cancer

Researchers uncover role of perivascular cells in blood vessel dysfunction

Women experience higher waiting-list mortality in lung transplantation

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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