Therapeutics News and Research

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Targeted pulses of ultrasound can help treat a range of brain diseases

Ultrasound is not only used as an imaging technique but targeted pulses of ultrasound can be used as a highly accurate treatment for a range of brain diseases, for which there were previously only limited treatment options.

5 Feb 2021

Alpaca nanobodies neutralize SARS-CoV-2 in vitro

A new preprint research paper posted to the bioRxiv server reports the development of highly effective neutralizing nanobodies targeting the viral receptor-binding domain (RBD), thus disrupting its engagement with the host cell angiotensin-converting enzyme 2 (ACE2) receptor.

4 Feb 2021

SHREK proteins mediate broad spectrum antiviral host immunity, including against SARS-CoV-2

A new preprint posted to the bioRxiv server demonstrates that similar mucins and mucin-like proteins cannot only suppress HIV-1 infectivity via blockage of viral attachment to the host cells but can block infection by multiple enveloped viruses.

4 Feb 2021

Finding ways to relieve painful intercourse

Researchers at Flinders University are working to remedy this situation by identifying what triggers this chronic pain in the female reproductive tract.

4 Feb 2021

New drug candidate to be trialed for most lethal form of brain cancer

A new drug candidate has been discovered by the University of South Australia to treat the most lethal form of brain cancer - glioblastoma - which kills 95 per cent of patients within five years.

4 Feb 2021

Study shows how SARS-CoV-2 evades immune responses

In a recurring pattern of evolution, SARS-CoV-2 evades immune responses by selectively deleting small bits of its genetic sequence, according to new research from the University of Pittsburgh School of Medicine.

4 Feb 2021

Researchers to develop new test method to assess preventative surface cleansers

A CONCEPT known as dry biofilms has emerged over the past few years and they have shown to frequently harbour potentially infectious organisms, just like the ones present in Hospital Acquired Infections (HAIs).

4 Feb 2021

Study shows how tissue damage promotes the earliest stages of pancreatic cancer

Like weeds sprouting from cracks in the pavement, cancer often forms in sites of tissue damage. That damage could be an infection, a physical wound, or some type of inflammation.

4 Feb 2021

Spark Therapeutics launches gene therapy clinical trial for late-onset Pompe disease

Pompe disease is a hereditary genetic disorder caused by a deficiency of acid alpha-glucosidase leading to build-up of glycogen in the lyosomes, which then causes cell damage in various tissues, in particular the heart, the muscles, the liver and the nervous system.

3 Feb 2021

CU researchers awarded NEI's 3D ROC prize to accelerate development of new therapies

Natalia Vergara, PhD, assistant professor of ophthalmology at the University of Colorado School of Medicine, has been awarded a 3D ROC prize by the National Eye Institute for her research team's work to create better models to accelerate the development of new therapies for retinal diseases.

3 Feb 2021

Researchers engineer "Nanotraps" that block SARS-CoV-2 infection

Researchers at Chicago University have developed an innovative new anti-SARS-CoV-2 therapy called “Nanotraps” – a family of nano-enabled virus-trapping particles – which have shown positive results in vitro, in vivo, and in human ex vivo trials.

3 Feb 2021

Novel 3D-printed esophageal stents could revolutionize the delivery of cancer treatment

World-first 3D printed esophageal stents developed by the University of South Australia could revolutionize the delivery of chemotherapy drugs to provide more accurate, effective and personalized treatment for patients with esophageal cancer.

3 Feb 2021

Novel strategy redirects generic antibodies to SARS-CoV-2 spike proteins

The SARS-CoV-2, the new coronavirus behind the current pandemic, infects humans by binding its surface-exposed spike proteins to ACE2 receptors exposed on the cell membranes.

3 Feb 2021

Key variants help explain the differences between viruses that cause COVID-19 and SARS

An effort led by Lin Li, Ph.D., assistant professor of physics at The University of Texas at El Paso, in collaboration with students and faculty from Howard University, has identified key variants that help explain the differences between the viruses that cause COVID-19 and Severe Acute Respiratory Syndrome (SARS).

3 Feb 2021

Single-dose vaccination effective for healthcare workers with prior SARS-CoV-2 infection

The findings reveal that healthcare workers previously infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop significantly higher antibody titers in response to a single dose of COVID-19 vaccine, as compared to healthcare workers without prior SARS-CoV-s infection. The study is currently available on the medRxiv* preprint server.

2 Feb 2021

Remyelinating drug shows potential to improve vision in patients with MS

A team led by a biomedical scientist at the University of California, Riverside, reports a drug -- an estrogen receptor ligand called indazole chloride (IndCl) -- has the potential to improve vision in patients with multiple sclerosis, or MS.

2 Feb 2021

Automated method identifies and tracks harmful tau deposits involved in Alzheimer's disease

Amyloid-beta and tau are the two key abnormal protein deposits that accumulate in the brain during the development of Alzheimer's disease, and detecting their buildup at an early stage may allow clinicians to intervene before the condition has a chance to take hold.

2 Feb 2021

CoCID project aims to develop soft X-ray microscope for visualizing cellular origin of diseases

CoCID (Compact Cell Imaging Device), a €5.7 million, four-year, pan-European research and innovation project, funded through Horizon 2020, has officially commenced.

2 Feb 2021

ZyCoV-D DNA vaccine immunogenic against SARS-CoV-2 in animal models

In the absence of effective therapeutics or preventives, vaccines have become the focus of attention. Though over 170 vaccines are in preclinical and about 60 in clinical development, very few are based on plasmid DNA technology. However, a new preprint research paper posted to the bioRxiv* server reports the immunogenicity of a DNA vaccine candidate.

2 Feb 2021

Study discovers promising therapeutic agent to inhibit melanoma progression

There have been great advances in treating melanoma over the past five years, however, even with these treatments many patients quickly develop drug resistance and die from their disease.

1 Feb 2021

Therapeutics News and Research

Targeted pulses of ultrasound can help treat a range of brain diseases

Alpaca nanobodies neutralize SARS-CoV-2 in vitro

SHREK proteins mediate broad spectrum antiviral host immunity, including against SARS-CoV-2

Finding ways to relieve painful intercourse

New drug candidate to be trialed for most lethal form of brain cancer

Study shows how SARS-CoV-2 evades immune responses

Researchers to develop new test method to assess preventative surface cleansers

Study shows how tissue damage promotes the earliest stages of pancreatic cancer

Spark Therapeutics launches gene therapy clinical trial for late-onset Pompe disease

CU researchers awarded NEI's 3D ROC prize to accelerate development of new therapies

Researchers engineer "Nanotraps" that block SARS-CoV-2 infection

Novel 3D-printed esophageal stents could revolutionize the delivery of cancer treatment

Novel strategy redirects generic antibodies to SARS-CoV-2 spike proteins

Key variants help explain the differences between viruses that cause COVID-19 and SARS

Single-dose vaccination effective for healthcare workers with prior SARS-CoV-2 infection

Remyelinating drug shows potential to improve vision in patients with MS

Automated method identifies and tracks harmful tau deposits involved in Alzheimer's disease

CoCID project aims to develop soft X-ray microscope for visualizing cellular origin of diseases

ZyCoV-D DNA vaccine immunogenic against SARS-CoV-2 in animal models

Study discovers promising therapeutic agent to inhibit melanoma progression

Event guide: The Non-Opioid Pain Therapeutics Summit eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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